CAS: 1340593-59-0; (R)-2-(2,4-Difluorophenyl)-1,1-Difluoro-3-(1H-Tetrazol-1-yl)-1-(5-(4-(2,2,2-Trifluoroethoxy)Phenyl)Pyridin-2-yl)Propan-2-Ol

上下游产品

2-(2,4-Difluorophenyl)-1,1-Difluoro-3-(1H-Tetrazol-1-yl)-1-(5-(4-(2,2,2-Trifluoroethoxy)Phenyl)Pyridin-2-yl)Propan-2-Ol 1340593-77-2
2-[[2-(2,4-Difluorophenyl)Oxiran-2-Yl]-Difluoromethyl]-5-[4-(2,2,2-Trifluoroethoxy)Phenyl]Pyridine 1340593-92-1
5-Bromo-2-((2-(2,4-Difluorophenyl)Oxiran-2-yl)Difluoromethyl)Pyridine 294182-28-8

2,5-二溴吡啶置于正丁基锂,Palladium Bis[bis(Diphenylphosphino)Ferrocene] Dichloride,叠氮基三甲基硅烷,Potassium Tert-Butylate,氨,Sodium Acetate,铜,Potassium Carbonate,溶剂黄146体系中,用 四氢呋喃,甲醇,甲基叔丁基醚,水,二甲基亚砜,异丙醇,乙腈,仲丁醇 用作溶剂,化学反应生成奥特康唑
参考文献:Oteseconazole. Fungal Lanosterol 14Alpha-Demethylase (Cyp51) Inhibitor,Treatment Of Recurrent Vulvovaginal Candidiasis,Treatment Of Onychomycosis
标题:Oteseconazole. Fungal Lanosterol 14Alpha-Demethylase (Cyp51) Inhibitor,Treatment Of Recurrent Vulvovaginal Candidiasis,Treatment Of Onychomycosis
摘要:Developing A Rationally Designed,More Selective Azole Antifungal Agent That Specifically Targets The Fungal Cyp51 Over The Host Cyp51 Is A Severe Unmet Need Considering A Massive Shortfall In Novel Antifungal Agents. In This Context,Oteseconazole (Vt-1161) Represents A Very Exciting New Development Targeting Serious Fungal Infections Caused By A Wide Variety Of Fungal Pathogens Including Multidrug-Resistant Candida Responsible For Recurrent Vulvovaginal Candidiasis. This Monograph Details The Various In Vitro And In Vivo Properties Exhibited By Oteseconazole As Well As Its Current Status In Clinical Trials.
Doi:10.1358/dof.2019.44.11.3035583