CAS: 13384-48-0; Magnesium,Cyclobutane,Bromide

上下游产品

Brom°Cyclobutane magnesium(diphenylmethylene)cyclobutane cyclobutane 3-benzyloxycarbonylamino-4-cyclobutyl-4-oxobutyric acid tert-butyl ester (2-{[(3,5-bis-trifluoromethyl-benzyl)-(2-methyl-2H-tetrazol-5-yl)-amino]-methyl}-4-trifluoromethyl-phenyl)-cyclobutyl-methanol

📜环丁基溴置于magnesium,Lithium Chloride体系中,用 四氢呋喃 用作溶剂,化学反应生成环丁基溴化镁
参考文献:使用有机镁试剂进行铬 (II) 催化的非对映选择性和化学选择性 Csp2-Csp3 交叉偶联
标题:使用有机镁试剂进行铬 (II) 催化的非对映选择性和化学选择性 Csp2-Csp3 交叉偶联
摘要:已开发出一种在环境温度下用环己基碘对芳基镁卤化物进行铬催化的高度非对映选择性烷基化的简单方案.此外,这种不含配体的 Crcl2 能够使伯,仲和叔烷基卤化镁与容易获得的乙酸烯基酯进行有效的亲电烯基化.此外,这种与立体定义的烯基乙酸酯的化学选择性 C-C 偶联反应以立体保留方式进行.烷基碘化物和烯基乙酸酯上的各种官能团具有非常好的耐受性,从而以非常好的收率和高非对映选择性提供官能化的 Csp2-Csp3 偶联产物.详细的机理研究表明,原位生成的低价铬 (I) 物种可能是这些 Csp2-Csp3 交叉偶联的活性催化剂.
Doi:10.1021/jacs.9B08586

专利信息

专利号:US-2024400552-A1
优先权日:2016-11-11
标题 :Heterocyclic modulators of lipid synthesis
发明人：BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by dysregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

专利号:US-11622968-B2
优先权日:2011-03-08
标 题:Heterocyclic modulators of lipid synthesis
发明人：BUCKLEY DOUGLAS; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

专利号:US-10226449-B2
优先权日:2013-12-20
标 题:Heterocyclic modulators of lipid synthesis and combinations thereof
发明人：HEUER TIMOTHY SEAN; OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; DUKE GREGORY; OHOL-GUPTA YAMINI; O'FARRELL MARIE
权利人:3 V BIOSCIENCES INC
摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by dysregulation of a fatty acid synthase pathway by the administration of such compounds and combinations of such compounds and other therapeutic agents.

专利号:US-2024409557-A1
优先权日:2023-05-09
标 题 :5,6-fused and 6,6-fused bicyclic alcohols and ethers and compositions for use as 15-prostaglandin dehydrogenase modulators
发明人：GREENMAN KEVIN LLOYD; PICKRELL ALEXANDER J; LI KEXUE; AMEGADZIE ALBERT K; WANG HUI-LING; WEIRES NICHOLAS ANTHONY; ALLEN JOHN G; BOURBEAU MATTHEW P
权利人:AMGEN INC
摘要:The present disclosure provides novel 15-hydroxy-prostaglandin dehydrogenase inhibitors, pharmaceutical compositions comprising such compounds, and methods of using such compounds and compositions in treating 15-hydroxy-prostaglandin dehydrogenase-mediated disease. Also provided are methods of making such compounds and intermediates thereof. The compounds have a general Formula (A).Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (A).

专利号:US-2019308969-A1
优先权日:2016-11-11
标 题 :Heterocyclic modulators of lipid synthesis

专利号:US-2018222892-A1
优先权日:2012-07-03
标 题 :Heterocyclic modulators of lipid synthesis