CAS: 1225338-27-1; (1S)-3,4-Dihydro-1-Phenyl-2(1H)-Isoquinolinecarboxylic Acid-1-Azabicyclo[2.2.2]Oct-3-Yl Ester

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(S)-1-苯基-1,2,3,4-四氢-2-异喹啉甲酸乙酯 Ethyl (S)-1-Phenyl-3,4-Dihydroisoquinoline-2(1H)-Carboxylate 180468-42-2

📜奎宁环-3-醇,(S)-1-苯基-1,2,3,4-四氢-2-异喹啉甲酸乙酯,Sodium;Hydride,氯化钠置于氮,乙醇,甲苯,盐酸,乙酸乙酯,水,碳体系中,用 甲苯 用作溶剂,化学反应 24.67H,以to Produce 12 G Of (1S)-3,4-Dihydro-1-Phenyl-2(1H)-Isoquinolinecarboxylic Acid (3Rs)-1-Azabicyclo[2.2.2]oct-3-Yl Ester (Solifenacin And Its Diastereomer) As A Pale Yellow Oil的收率获得索利那新杂质18
参考文献:Novel Process For The Preparation Of Solifenacin Succinate
标题:Novel Process For The Preparation Of Solifenacin Succinate
摘要:本发明涉及一种制备左利福辛琥珀酸盐的方法,该方法通过将公式(ivb)的化合物与(rs)-3-喹诺啉醇缩合,其中r代表甲基,乙基,异丙基,以产生(1S)-3,4-二氢-1-苯基-2(1H)-异喹啉羧酸(3Rs)-1-氮杂双环[2.2.2]辛-3-酯的对映异构体混合物,该混合物在溶剂或溶剂混合物中与琥珀酸反应,以产生光学纯的左利福辛琥珀酸盐,化学式(x).