专利号:US-2024294462-A1 优先权日:2023-02-15 标题:Method for the Synthesis of Ionizable Lipids Using a Doubly Alkylated Intermediate 发明人:SAADATI FARIBA; TRAN HUY; CIUFOLINI MARCO; ATMURI N D PRASAD 权利人:NANOVATION THERAPEUTICS INC 摘要:Provided herein is a method for the preparation of ionizable, cationic amino lipids using a doubly alkylated nucleophilic intermediate to produce a ketone. The ketone, or a corresponding alcohol, is subjected to one or more synthesis steps to add an ionizable moiety thereto. The method can be advantageously employed for the synthesis of unsymmetrical analogues of the above lipids that would be considerably more difficult to make by alternative strategies. The method can also be used to prepare symmetrical ionizable, cationic amino lipids with fewer steps and/or with the use of fewer hazardous chemicals than known synthesis methods.
专利号:US-8084007-B2 优先权日:2004-01-30 标题 :Methods of synthesis of isotropically enriched borohydride and methods of synthesis of isotropically enriched boranes 发明人:SPIELVOGEL BERNARD; COOK KEVIN S 权利人:SPIELVOGEL BERNARD; COOK KEVIN S; SEMEQUIP INC 摘要:The invention provides new methods for the synthesis of isotopically enriched metal borohydrides, metal tetrahydroundecaborate salts, and decaborane from isotopically enriched 10 B-boric acid or 11 B-boric acid. The invention is particularly useful for synthesis of isotopically enriched sodium or lithium borohydride, MB 11 H 14 (where M is Li, Na, K, or alkylammonium), and decaborane.
专利号:US-6083976-A 优先权日:1998-01-12 标 题 :Method of synthesis of derivatives of aloesin 发明人:PADMAPRIYA ABEYSINGHE; JONES KENNETH N 权利人:UNIVERA PHARM INC 摘要:The present invention discloses a method for the synthesis of derivatives of aloesin, alkylated at the C-7 hydroxyl group. The present invention includes the modified aloesins produced by the method of this invention and the use of these compounds as skin whitening agents.
专利号:WO-2025109557-A1 优先权日:2023-11-24 标题:Process for the synthesis of monoesters of ethylenediaminetetraacetic acid 发明人:TERAZONO YUICHI 权利人:NUTRIEN AG SOLUTIONS CANADA INC 摘要:A process for the synthesis of a compound of Formula (I) is provided. (I) wherein R is selected from the group consisting of alkyl, alkenyl, alkynyl, and steroidyl. The process comprises reacting a compound of Formula (IIa), Formula (IIb) or a mixture thereof with a compound of Formula R-X, to obtain a compound of Formula (IIIa), a compound of Formula (IIIb) or a mixture thereof, wherein A+ is a cesium cation, a quaternary ammonium cation or a quaternary phosphonium cation, and X is a leaving group; and reacting the compound of Formula (IIIa), compound of Formula (IIIb) or mixture thereof with an acid to obtain a reaction product which comprises the compound of Formula (I). (IIa) (IIb) (IIIa) (IIIb)
专利号:US-5554753-A 优先权日:1993-08-25 标 题:Catalytic enantioselective synthesis of α-amino acid derivatives by phase-transfer catalysis 发明人:O'DONNELL MARTIN J; WU SHENGDE; ESIKOVA IRENA; MI AIQIAO 权利人:INDIANA UNIVERSITY FOUNDATION 摘要:Described are improved processes for the enantioselective synthesis of α-amino acids which involve combinations of solvents, highly-mixed and low-temperature reaction conditions, and novel catalysts. Also described are novel catalysts and precursors to α-amino acid derivatives.
专利号:US-7767826-B2 优先权日:2007-10-05 标题 :Process for the synthesis of L-(+)-ergothioneine 发明人:TRAMPOTA MIROSLAV 权利人:PHARMATECH INTERNATIONAL INC 摘要:This invention relates to a novel process for the preparation of optically pure L-(+)-ergothioneine. The process for the chemical synthesis of L-ergothioneine comprises steps which consist of reacting L-histidine alkyl ester with an acid halide, chloroformate or pyrocarbonate in the presence of a base, hydrolysis of the alkyl-(S,Z)-2,4,5-triamidopent-4-enoate to obtain a (S)-alkyl 2,5-diamido-4-oxopentanoate, acid catalyzed hydrolysis of the (S)-alkyl 2,5-diamido-4-oxopentanoate followed by reaction with a metal thiocyanate to obtain the thiohistidine, protection of the sulfur of thiohistidine as the tert-butyl thioether, dialkylation of the primary amine to obtain a tertiary amine, quaternization of the tertiary amine, and removal of the protecting group to obtain the desired (S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trialkylammonio)propanoate (I). This process affords a better yield and is capable of practical application at large scale.
参考标题:Simple Synthesis Of (Z)-12-Nonadecen-9-One, (Z)-13-Icosen-10-One, The Sex Pheromone Of Peach Fruit Moth, And (Z)-5-Undecen-2-One, A Biologically Active Molecule From The Pedal Gland Of The Bontebok 作者:Masakazu Yamashita,Kaoru Matsumiya,Kotomi Murakami,Rikisaku Suemitsu |发布日期:1988.9 摘要:A Simple And Convenient Synthesis Of (Z)-12-Nonadecen-9-One, (Z)-13-Icosen-10-One, The Sex Pheromone Of The Peach Fruit Moth, And (Z)-5-Undecen-2-One, The Pheromone From The Pedal Gland Of The Bontebok, Is Described. These Pheromones Were Readily Synthesized Using Successive Alkylation Of Acetone Dimethylhydrazone In One-Pot.
合成参考文献
摘要:Haino, T.; Iwamoto, H., Science of Synthesis, (2010) 45, 1233. 摘要:Haino, T.; Iwamoto, H., Science of Synthesis, (2010) 45, 1225. 摘要:Black, D. A.; Fagnou, K., Science of Synthesis, (2010) 45, 636. 摘要:Yus, M.; Foubelo, F., Science of Synthesis, (2010) 47, 1103. 摘要:Eilbracht, P., Science of Synthesis, (2009) 48, 394.