专利号:WO-2023012205-A1 优先权日:2021-08-05 标 题 :Synthesis of specific butyrate compounds 发明人:BONRATH WERNER; GOETZINGER ALISSA; PACE FRANCESCO; WUESTENBERG BETTINA 权利人:DSM IP ASSETS BV 摘要:The present invention relates to new specific butyrate compounds to a new and improved synthesis of specific butyrates as well their use. Butyrate compounds are very useful compounds, either as such or as intermediates in organic synthesis.
专利号:US-5139940-A 优先权日:1989-10-26 标题 :Activation compounds and methods of synthesis of activation compounds 发明人:ISAACS STEPHEN T; CIMINO GEORGE D; METCHETTE KENNETH C; TESSMAN JOHN W 权利人:ISAACS STEPHEN T; CIMINO GOERGE D; METCHETTE KENNETH C; TESSMAN JOHN W 摘要:The invention is directed to isopsoralen compound compositions that contain a variety of substitutions which yet permit their binding to nucleic acid polymers. Reaction conditions that activate these bound isopsoralens results in covalent crosslinking to the nucleic acid polymers. The resultant complex is inhibited from being a template for the template-directed enzymatic synthesis of a complementary nucleic acid polymer. Beside the isopsoralens compositions, the invention includes their synthesis, the nucleic acid complex production and detection, and the above inhibitory method of use of the isopsoralens.
专利号:WO-2024084491-A1 优先权日:2022-10-21 标题:Process for synthesis of res metirom and its intermediates thereof 发明人:MEHTA NILESH VIPINCHANDRA 权利人:MEHTA NILESH VIPINCHANDRA 摘要:The present invention discloses a process for synthesis of Res metirom and its intermediates thereof. More particularly, the invention discloses process for synthesis of a key intermediate, 6-(4-amino, 2,6-dichlorophenoxy)4- isopropylpyridazin-3(2H)-one, of Res metirom via novel intermediate compounds of formula A. Wherein, R is selected from methyl, ethyl and propyl.
专利号:US-9029547-B1 优先权日:2013-12-07 标 题 :Synthesis of 4-aryl 4-acyl piperidine, its salts and analogs using indium metal 发明人:MAJEED MUHAMMED; RAMANUJAM RAJENDRAN; NAGABHUSHANAM KALYANAM 权利人:MAJEED MUHAMMED; RAMANUJAM RAJENDRAN; NAGABHUSHANAM KALYANAM 摘要:A novel process for the synthesis of 4-aryl 4-acyl piperidine derivatives using indium metal is described. Specifically, a novel process for the synthesis of 4-acetyl 4-phenyl piperidine and its salts using indium metal is described. This divisional application is specifically drawn to compounds 4-aryl 1,4-diacyl piperidine and 1,4 diacetyl 4-phenyl piperidine.
专利号:US-9056868-B1 优先权日:2012-09-13 标题 :Three-step synthesis of CL-20 发明人:WRIGHT MICHAEL E 权利人:US NAVY 摘要:Embodiments of the invention relate to the synthesis of CL-20 using only a three step synthesis and because of increased catalyst activity and lifetimes, a continuous flow process can be used with a tremendous reduction in total cost of producing CL-20.
专利号:US-2024317784-A1 优先权日:2021-07-13 标题 :Process for the synthesis of 4-((r)-2-{[6-((s)-3-methoxy-pyrrolidin-1-yl)-2-phenyl-pyrimidine-4-carbonyl]-amino}-3-phosphono-propionyl)-piperazine-1-carboxylic acid butyl ester 发明人:BLUMER NICOLE; CLAVEAU ROMAIN; FEYEN FABIAN; HALL LEANNE; HUGHES STEPHEN; REBER STEFAN 权利人:VIATRIS ASIA PACIFIC PTE LTD 摘要:The present invention relates to a process for the synthesis of 4-((R)-2-{[6-((S)-3-methoxy-pyrrolidin-1-yl)-2-phenyl-pyrimidine-4-carbonyl]-amino}-3-phosphono-propionyl)-piperazine-1-carboxylic acid butyl ester, or of a hydrochloride salt thereof; and to a crystalline form of 4-((R)-2-{[6-((S)-3-methoxy-pyrrolidin-1-yl)-2-phenyl-pyrimidine-4-carbonyl]-amino}-3-phosphono-propionyl)-piperazine-1-carboxylic acid butyl ester hydrochloride.
参考标题:Synthetic Studies In The Lysocellin Family Of Polyether Antibiotics. The Total Synthesis Of Ferensimycin B 作者:David A. Evans,Richard P. Polniaszek,Keith M. Devries,Denise E. Guinn,David J. Mathre |发布日期:1991.9 摘要:A Convergent Asymmetric Synthesis Of The Polyether Antibiotic Ferensimycin B Has Been Completed. Chiral Enolate Bond Constructions Were Employed To Establish Seven Of The 16 Stereocenters Of The Subunits 35 And 52, Which Comprise The C& And Ci&3 Portions Of Ferensimycin B. The Stereogenic Centers At C3, C4, Cg, Clo, Ci6, C,,, And Cis Were Incorporated Through Internal Asymmetric Induction, While Those
合成参考文献
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