CAS: 1004972-49-9; 1-((6-Methylpyridazin-3-yl))Methanamine
该化合物是一种环环环的杂交有机化合物,其特点是存在一个有六人组成的芳香环,内含两个氮原子;该化合物的特点是一个氨基氨基化合物(-NH2)和一个附属于结构的甲基组(-CH3),影响其化学反应和潜在应用;该氨基汞组可参与各种化学反应,包括核生殖替代和混合反应,使其成为有机合成中的宝贵中间体;该甲基组可促进该化合物的水恐惧特性,影响溶解性和与生物系统的互动;该组可能展示生物活动,可以在制药研究中加以探讨,特别是在开发新药物或农用化学品方面,其具体特性,如熔点,沸点和溶性,取决于分子相互作用和研究中的环境;总体而言,3-氨甲基-6-甲基-甲基丙烯基胺对合成化学和潜在药用都有意义.
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1337879-71-6 1630907-25-3 1936703-98-8MSDS等安全信息
合成工艺路线路线简述
📜6-甲基吡嗪-3-甲腈置于pd-Baso4 盐酸,氢气体系中,用 溶剂黄146 用作溶剂,化学反应 5.0H,反应生成6-甲基-3哒嗪甲基胺
参考文献:High-Efficacy 5-Ht1A Agonists For Antidepressant Treatment: A Renewed Opportunity
标题:High-Efficacy 5-Ht1A Agonists For Antidepressant Treatment: A Renewed Opportunity
摘要:We Report The Discovery Of Novel 5-Ht1A Receptor Agonists And Describe The Process That Led To The Antidepressant Candidate 9 (F 15599). 9 Has Nanomolar Affinity For 5-Ht1A Binding Sites And Is Over 1000-Fold Selective With Respect To The Other 5-Ht1 Receptor Subtypes,5-Ht2-7 Receptor Families,And Also Numerous Gpcrs,Transporters,Ion Channels,And Enzymes. In A Cellular Model Of Signal Transduction,9 Activates H5-Ht1A Receptors With An Efficacy Superior To That Of The Prototypical 5-Ht1A Agonist (+/-)-8-Oh-Dpat And Comparators Undergoing Clinical Trials. After Acute Oral Administration In Rats,9 Totally Reverses Immobility In The Forced Swimming Test And Produces Behaviors Characteristic Of 5-Ht1A Receptor Activation. However,These Effects occurred At Widely Separated Doses,Suggesting That 9 Discriminates Between Distinct Populations Of 5-Ht1A Receptors. While The Clinical Relevance Of These Observations Is Still Unknown,This Opens New Perspectives For The Treatment Of Depressive Disorders.
Doi:10.1021/jm070714L
