CAS: 89856-44-0; 5-Bromo-4,6-Dimethylpyridin-2-Amine

该化合物是一种异环有机化合物,在4和6位置的5个位置和甲基组中以溴取代了一条核核心,在4和6位置的4和6位置的甲基组中,与一个氨基组一起,在2位置的2位置上,这种结构具有独特的反应性,使它在制药和农用化学合成中成为有价值的中间体.溴代金在相互交织的反应中增强了其效用,如Suzuki或Buchwald-Hartwig的交织,从而能够有效地衍生.

英文名称5-Bromo-4,6-Dimethylpyridin-2-Amine
中文名称2-氨基-5-溴-4,6-二甲基吡啶
IUPAC名称5-bromo-4,6-dimethylpyridin-2-amine
其它别名2-氨基-4,6-二甲基-5-溴吡啶; 2-Pyridinamine, 5-Bromo-4,6-Dimethyl-
CAS编号89856-44-0
MFCD编号:MFCD00151793
EINECS号:626-748-3
分子式:C7H9BrN2
分子量:201.06
产品CID: 1920556
产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

相似结构搜索
InChIKey: BFRMYMFNSHASRJ-UHFFFAOYSA-N
InChI=1S/C7H9BrN2/c1-4-3-6(9)10-5(2)7(4)8/h3H,1-2H3,(H2,9,10)…
计算化学: 氢键受体数2.0氢键供体数1.0可旋转键数0.0

相似化合物

42753-71-9 98198-48-2 91872-10-5

MSDS等安全信息

GHS象形图
GHS符号GHS07 & GHS05;
注释: Exclamation mark & Corrosion
危险类别急性毒性类别4(经口)
严重眼损伤类别1
皮肤致敏类别1
警示词Danger(危险)
危险描述H302 |吞咽有害.
H318 |造成严重眼损伤.
H317 |可能引起皮肤过敏反应.
防范说明P261-P264-P270-P272-P280-P302+P352-P330-P362+P364-P501
危险等级8
UN编号1759.0
危险品标志Xn
包装等级Ⅲ
安全声明26-36/37/39
危险类别码22-41-43
WGK Germany3

欧盟法规

ECHA物质C&L通报

上下游产品

合成工艺路线路线简述

5407-87-4 = 89856-44-0
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile; 5 H,Rt
标题:Analysis Of The Structural And Mechanistic Factors In Antioxidants That Preserve Mitochondrial Function And Confer Cytoprotection
作者:Arce,Pablo M.; Goldschmidt,Ruth; Khdour,Omar M.; Madathil,Manikandadas M.; Jaruvangsanti,Jennifer; Et Al
参考文献:Bioorganic & Medicinal Chemistry 日期:2012 卷标:20(17) 页码:5188-5201]

5407-87-4 = 89856-44-0
反应条件:1.1 Reagents: Bromine Solvents: Acetic Acid; 15 Min,< 20 °C; 1 H,Rt1.2 Reagents: Sodium Hydroxide Solvents: Water; Basified,Cooled
标题:The Potential Role Of Anibamine,A Natural Product Ccr5 Antagonist,And Its Analogues As Leads Toward Development Of Anti-Ovarian Cancer Agents
作者:Zhang,Yan; Arnatt,Christopher K.; Zhang,Feng; Wang,Jiannan; Haney,Kendra M.; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2012 卷标:22(15) 页码:5093-5097]

5407-87-4 = 89856-44-0
反应条件:1.1 Reagents: 1,3-Dibromo-5,5-Dimethylhydantoin Solvents: Dichloromethane; 45 Min,-40 °C
标题:Synthesis And Reactivity Of Some 6-Substituted-2,4-Dimethyl-3-Pyridinols,A Novel Class Of Chain-Breaking Antioxidants
作者:Wijtmans,Maikel; Pratt,Derek A.; Brinkhorst,Johan; Serwa,Remigiusz; Valgimigli,Luca; Et Al
参考文献:Journal Of Organic Chemistry 日期:2004 卷标:69(26) 页码:9215-9223]

5407-87-4 = 89856-44-0
反应条件:1.1 Reagents: Bromine Solvents: Acetic Acid; 20 Min,< 20 °C; 1 H,Rt1.2 Reagents: Sodium Hydroxide Solvents: Water
标题:Syntheses Of Two Potential Food Mutagens
作者:Tanga,M. J.; Bradford,W. W.; Bupp,J. E.; Kozocas,J. A.
参考文献:Journal Of Heterocyclic Chemistry 日期:2003 卷标:40(4) 页码:569-573]

5407-87-4 = 89856-44-0
反应条件:1.1 Reagents: 2,5-Di-Tert-Butylhydroquinone Solvents: Dichloromethane; 30 Min,< -5 °C; 2 H,-5 °C1.2 Reagents: Sodium Sulfite Solvents: Water; -5 °C -> 10 °C1.3 Reagents: Sodium Hydroxide Solvents: Water; Ph 13 - 14,10 °C
标题:Practical Convergent Laboratory-Scale Synthesis Of A Ccr5 Receptor Antagonist
作者:Crawford,Jason B.; Chen,Gang; Carpenter,Bryon; Wilson,Trevor; Ji,Jenny; Et Al
参考文献:Organic Process Research & Development 日期:2012 卷标:16(1) 页码:109-116]

5407-87-4 = 89856-44-0
反应条件:1.1 Reagents: Acetic Acid,Bromine
标题:N-Pyridinyl(Alkyl)Polyhalogenobenzamides Acting As Tnf-α Production Inhibitors
作者:Collin,X.; Robert,J. -M.; Robert,S.; Le Baut,G.; Bobin-Dubigeon,C.; Et Al
参考文献:Pharmacy And Pharmacology Communications 日期:1999 卷标:5(3) 页码:233-238]

5407-87-4 = 89856-44-0
反应条件:1.1 Reagents: 1,3-Dibromo-5,5-Dimethylhydantoin Solvents: Dichloromethane; 30 Min,-50 °C1.2 Reagents: Sodium Carbonate Solvents: Water; -50 °C -> Rt
标题:First Demonstration Of Positive Allosteric-Like Modulation At The Human Wild Type Translocator Protein (Tspo)
作者:Narlawar,Rajeshwar; Werry,Eryn L.; Scarf,Alana M.; Hanani,Raphy; Chua,Sook Wern; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2015 卷标:58(21) 页码:8743-8749]

5407-87-4 = 89856-44-0
反应条件:1.1 Reagents: P-Toluenesulfonic Acid,Butylpyridinium Bromide,Hydrogen Peroxide Solvents: 1,2-Dimethoxyethane; 24 H,80 °C
标题:A Mild Method For The Regioselective Bromination Of 2-Aminopyridines
作者:Xu,Tong; Zhou,Wen; Wang,Jing; Li,Xue; Guo,Jun-Wen; Et Al
参考文献:Tetrahedron Letters 日期:2014 卷标:55(36) 页码:5058-5061]

5407-87-4 = 89856-44-0
反应条件:1.1 Reagents: Bromine Solvents: Acetic Acid; 15 Min,< 20 °C; 1 H,Rt; Cooled1.2 Reagents: Sodium Hydroxide Solvents: Water; Basified,Cooled
标题:Structure Activity Relationship Studies Of Natural Product Chemokine Receptor Ccr5 Antagonist Anibamine Toward The Development Of Novel Anti Prostate Cancer Agents
作者:Zhang,Feng; Arnatt,Christopher K.; Haney,Kendra M.; Fang,Harrison C.; Bajacan,John E.; Et Al
参考文献:European Journal Of Medicinal Chemistry 日期:2012 卷标:55 页码:395-408]

5407-87-4 = 89856-44-0
反应条件:1.1 Reagents: 1,3-Dibromo-5,5-Dimethylhydantoin Solvents: Dichloromethane; 40 Min,-40 °C
标题:6-Amino-3-Pyridinols: Towards Diffusion-Controlled Chain-Breaking Antioxidants
作者:Wijtmans,Maikel; Pratt,Derek A.; Valgimigli,Luca; Dilabio,Gino A.; Pedulli,Gian Franco; Et Al
参考文献:Angewandte Chemie 日期:2003 卷标:42(36) 页码:4370-4373]

5407-87-4 = 89856-44-0
反应条件:1.1 Reagents: Bromine Solvents: Acetic Acid
标题:Anibamine And Its Analogues: Potent Antiplasmodial Agents From Aniba Citrifolia
作者:Du,Yongle; Valenciano,Ana Lisa; Dai,Yumin; Zheng,Yi; Zhang,Feng; Et Al
参考文献:Journal Of Natural Products 日期:2020 卷标:83(3) 页码:569-577

N-(5-Bromo-4,6-Dimethyl-[2]Pyridyl)-Acetamide置于sodium Hydroxide体系中,化学反应生成 2-氨基-5-溴-4,6-二甲基吡啶
参考文献:α-Oxygenated Pyridines. Iii. The Reaction Of N-Bromosuccinimide With Some Pyridine Derivatives1
标题:α-Oxygenated Pyridines. Iii. The Reaction Of N-Bromosuccinimide With Some Pyridine Derivatives1
摘要:
DOI:10.1021/ja01128A013

海关参考信息

2933310010-吡啶
2939800000-其他生物碱
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-5424432-A
优先权日:1994-05-26
标题:Process for the preparation of imidazolutidine
发明人：FREDENBURGH LAURA E; LARSEN ROBERT D; LIU JI; REAMER ROBERT A; SENANAYAKE CHRIS H; VERHOEVEN THOMAS R
权利人:MERCK & CO INC
摘要:This invention relates to a method for the preparation of a compound of formula I: I a key intermediate in the synthesis of a series of Angiotensin II receptor antagonists. The invention also relates to a selective reagent for conducting the Hofmann rearrangement, particularly in the formation of a pyridinoimidazolone, which is a percursor to the formation of an imidazopyfidine of formula I. This invention also relates to a method for the preparation of imidazolutidine, a key intermediate in the synthesis of 3-(2'-(N-benzoyl)sulfonamidobiphen-4-yl)-methyl-5,7 -dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridine, using pyridinoimidazolone, an unreactive urea.