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4-甲基乙酰苯胺置于硫酸,Potassium Nitrate,Potassium Hydroxide体系中,用 甲醇,水 作为反应溶剂,化学反应 4.0H,反应生成 4-甲基-2-硝基苯胺
参考文献:吲地磺草胺的微妙结构改变改变了抑制胃癌细胞迁移的分子机制
标题:吲地磺草胺的微妙结构改变改变了抑制胃癌细胞迁移的分子机制
摘要:胃癌是一种高度转移的恶性肿瘤,在全球范围内发病率和死亡率较高.最近的研究报告称,磺酰胺衍生物(例如吲地磺草胺)对癌细胞的活力和迁移具有抑制作用.然而,多项临床试验表明,吲地磺草胺并不能显着阻止由于转移和耐药性而导致的癌症进展.因此,有必要发现新的有效衍生物来探索替代治疗策略.在这里,我们合成了多种吲地磺草胺衍生物,并检查它们对胃癌细胞活力和迁移的抑制作用.其中,化合物sr-3-65和wxm-1-170对胃癌细胞迁移的抑制作用优于indisulam.从机制上讲,我们发现它们可以减弱 Pi3K/akt/gsk-3β/β-Catenin 信号通路,并导致上皮间质转化 (Emt) 相关转录因子的抑制. Sr-3-65对胃癌细胞迁移的影响被pi3K抑制剂ly294002阻断,而sr-3-65和wxm-1-170逆转pi3K激活剂740 Yp对胃癌细胞迁移的影响.分子对接和分子动力学模拟进一步证实pi
DOI:10.1016/j.Biopha.2024.116259

专利信息

专利号:WO-2024009918-A1
优先权日:2022-07-04
标 题 :Ammonia synthesis catalyst and ammonia synthesis method
发明人：YAYAMA YOSHIHIRO; UGAJIN TAKUYA
权利人:ENEOS CORP
摘要:An ammonia synthesis catalyst according to the present invention contains one or more components selected from the group consisting of IrSc, FePd3, MnTc3, IrY, CrPd3, MnPd3, RhY, Co3Pt, CrPt3, FeRh3, CrRh3, Ni3Ti, Ir3V, Pt3Ti, Co3Rh, Pd3Ti, Ni3Zr, Co3W, NiPd3, FeNi3, Ir3Mn, IrMn, MnPt, MnNi3, Ir3Re, MnRh, Pd3V, MnPt3, Rh3V, and Rh3Ti.

专利号:US-4719053-A
优先权日:1980-08-01
标题 :Beta-chloroethylsulfonylmethyl-benzoic halides as intermediates
发明人：SCHLAEFER LUDWIG; HAEHNLE REINHARD
权利人:HOECHST AG
摘要:New beta -chloroethylsuflonylmethyl-benzoic acid halides which can serve as fibre-reactive anchors for thesynthesis of novel organic, water-soluble compounds, preferably dyestuffs, having fibre-reactive and fibre-finishing properties, such as preferably dyestuff properties, and containing, as a fibre-reactive group, one or two beta -chloroethylsufonylmethylbenzoic acid amide groups. For the synthesis of these novel fibre-finishing compounds, said new beta -chloroethylsulfonylmethyl-benzoic acid halide compounds are reacted with an organic, water-soluble compound having fibre-finishing properties and continuing one or two amino groups. Also precursors of the fibre-finishing, fibre-reactive compounds, containing said beta -chloroethylsulfonylmethyl-benzxoic acid amid grouping, can be employed for their synthesis. The novel fibre-finishing compounds can be applied onto suitable fibre materials, such as especially cellulose fibre material and natural or synthetic polyamide fibre materials, and fixed on these fibre materials in a manner similar to application and fixation methods usual in the technique for fibre-reactive compounds. The fibre-finished material, such as dyed material, shows very good wet fastnesses.

专利号:US-RE42890-E
优先权日:2003-05-23
标题 :Furazanobenzimidazoles
发明人：EBERLE MARTIN; BACHMANN FELIX; STREBEL ALESSANDRO; ROY SUBHO; SRIVASTAVA SUDHIR; SAHA GOUTAM
权利人:BASILEA PHARMACEUTICA AG
摘要:The invention relates to compounds of formula (I) wherein R represents aryl or heteroaryl, X is oxygen, a carbonyl group, an oxime derivative of a carbonyl group or an α,β-unsaturated carbonyl group, and the substituents R 1 to R 6 have the meanings given in the specification, for use as medicaments, to novel compounds of formula (I), to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I), to the use of a compounds of formula (I) for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using such compounds of formula (I) or of pharmaceutical compositions containing same

专利号:US-4118384-A
优先权日:1976-02-21
标题 :Process for preparation of azo dyestuffs by coupling in presence of aromatic sulphonic acid-formaldehyde reaction product
发明人：MOLLS HANS-HEINZ; SCHIWY WILLY; HORNLE REINHOLD; NEBELING REINHARD
权利人:BAYER AG
摘要:Dyestuff dispersions and dyestuff solutions free from salt or at least having a low salt content are obtained in that the diazotization is carried out with addition of free dispersing agent acid to which, after the synthesis, either no basic agents are added or basic agents are added only up to a pH value of 3. The disclosed process gives dyestuff compositions of low salt content and results in readily dispersible dyestuffs when water insoluble dyestuffs are prepared and stable solutions when water soluble dyestuffs are prepared. The process is widely applicable and chemical constitution of the dyestuffs is conventional.

专利号:CN-113828342-A
优先权日:2021-09-30
标 题:Cu-Pd-CeO2/γ-Al2O3Preparation of @ NP catalyst and synthesis of benzopyrazine compounds

专利号:US-4035350-A
优先权日:1975-01-30
标 题:Process for the preparation of water-soluble azo dyestuffs by reacting an aromatic amine and a coupling component with alkali metal nitrite or alkyl nitrite in the absence of acid
发明人：LANDLER JOSEF; WORFEL ERHARD
权利人:HOECHST AG
摘要:A new and very advantageous Process had been found for the preparation of azo dyestuffs by diazotation and coupling in which the synthesis is carried out without the hitherto usual addition of an acid, with the proviso that at least one of the diazo and coupling components contains at least one acid group. Besides the saving of reaction material and subsequently of alkali for neutralization of the reaction medium and isolation of the dyestuff, highly concentrated solutions of the dyestuff and salt-free or practically salt-free dyestuffs can be obtained, and waste-water is no longer charged with big amounts of salts.