CAS: 80983-45-5; Methyl (5-(Methylthio)-1H-Benzo[d]Imidazol-2-yl)Carbamate

该化合物是一种广泛分光的炭疽剂的甲基衍生物. 这种改变增强了其脂性,有可能比母体化合物提高生物利用率和组织渗透率. S-甲基组具有更大的代谢稳定性,这可能会延长其治疗活动. 和albendazole一样,它通过抑制微囊聚合,干扰寄生虫能源代谢,表现出对抗线虫,阴极和流的功效. 它的结构优化使得它成为进一步进行药理评估的候选物,特别是在抗抗性导导感染方面. 研究应用包括比较药动能研究和调查联苯胺醇类内的结构活动关系. 由于它可能对光和湿气具有敏感性,需要适当的处理和储存.

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物理性质

MSDS等安全信息

合成工艺路线路线简述

  • 51234-98-1 + 67469-02-7 = 80983-45-5
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Acetone,Water; 23 - 25 °C; 3 H,80 - 85 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 4.0 - 4.5
    标题:Synthesis And Characterization Of Impurities Of Broad- Spectrum Anthelmintic Drug,Albendazole
    作者:Kalas,Sabrintaj; Et Al
    参考文献:Chemical Science Transactions 日期:2016 卷标:5(1) 页码:79-86]

    23153-09-5 = 80983-45-5
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Ethanol,Water; 10 Min,10 - 15 °C; 15 °C -> 25 °C1.2 Reagents: Iron; 4 H,23 - 25 °C1.3 Reagents: Sodium Hydroxide Solvents: Ethyl Acetate,Water; Basified2.1 Reagents: Hydrochloric Acid Solvents: Acetone,Water; 23 - 25 °C; 3 H,80 - 85 °C2.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 4.0 - 4.5
    标题:Synthesis And Characterization Of Impurities Of Broad- Spectrum Anthelmintic Drug,Albendazole
    作者:Kalas,Sabrintaj; Et Al
    参考文献:Chemical Science Transactions 日期:2016 卷标:5(1) 页码:79-86]

    420-04-2 = 80983-45-5
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water; Ph 7 - 7.5,< 10 °C; 2 H,Ph 8 - 8.5,10 - 15 °C2.1 Reagents: Hydrochloric Acid Solvents: Acetone,Water; 23 - 25 °C; 3 H,80 - 85 °C2.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 4.0 - 4.5
    标题:Synthesis And Characterization Of Impurities Of Broad- Spectrum Anthelmintic Drug,Albendazole
    作者:Kalas,Sabrintaj; Et Al
    参考文献:Chemical Science Transactions 日期:2016 卷标:5(1) 页码:79-86]

    1943734-28-8 = 80983-45-5
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Methanol,Water; 25 °C -> 40 °C; 1 H,40 °C; 40 °C -> 15 °C1.2 15 °C -> 40 °C; 4 H,40 °C2.1 Reagents: Hydrochloric Acid Solvents: Ethanol,Water; 10 Min,10 - 15 °C; 15 °C -> 25 °C2.2 Reagents: Iron; 4 H,23 - 25 °C2.3 Reagents: Sodium Hydroxide Solvents: Ethyl Acetate,Water; Basified3.1 Reagents: Hydrochloric Acid Solvents: Acetone,Water; 23 - 25 °C; 3 H,80 - 85 °C3.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 4.0 - 4.5
    标题:Synthesis And Characterization Of Impurities Of Broad- Spectrum Anthelmintic Drug,Albendazole
    作者:Kalas,Sabrintaj; Et Al
    参考文献:Chemical Science Transactions 日期:2016 卷标:5(1) 页码:79-86]

    1762-95-4 = 80983-45-5
    反应条件:1.1 Reagents: Chlorine Solvents: Methanol; 6 H,23 - 25 °C; 2 H,23 - 25 °C2.1 Reagents: Sodium Hydroxide Solvents: Methanol,Water; 25 °C -> 40 °C; 1 H,40 °C; 40 °C -> 15 °C2.2 15 °C -> 40 °C; 4 H,40 °C3.1 Reagents: Hydrochloric Acid Solvents: Ethanol,Water; 10 Min,10 - 15 °C; 15 °C -> 25 °C3.2 Reagents: Iron; 4 H,23 - 25 °C3.3 Reagents: Sodium Hydroxide Solvents: Ethyl Acetate,Water; Basified4.1 Reagents: Hydrochloric Acid Solvents: Acetone,Water; 23 - 25 °C; 3 H,80 - 85 °C4.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 4.0 - 4.5
    标题:Synthesis And Characterization Of Impurities Of Broad- Spectrum Anthelmintic Drug,Albendazole
    作者:Kalas,Sabrintaj; Et Al
    参考文献:Chemical Science Transactions 日期:2016 卷标:5(1) 页码:79-86

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