CAS: 80-00-2; Sulphenone

该化合物是一种有机化合物,其特点是存在一个附于一个苯环和一个氯化苯基组的磺酰基(EurosO2),通常看起来像白到浅黄色晶体固体,在正常条件下因其稳定性而闻名;该化合物溶于丙酮和二氯甲烷等有机溶剂,但在水中溶解性有限;该化合物具有典型的全氟辛烷磺酸化合物特性,包括能够作为各种化学反应中的一种全氟辛烷磺酸剂;氯原子的存在增强了其再活性,使其在有机合成中有用,特别是在制药和农用化学品制作过程中.此外,4-氯苯基苯基磺酸可能会对健康造成危害,包括对皮肤,眼睛和呼吸系统造成刺激,因此在处理过程中必须采取适当的安全防范措施.其应用范围扩大到染料,聚合物和其他特殊化学品的生产,突出其在化学工业中的多变性.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

phenyl p-chlorophenyl sulfide methyl p-chlorobenzenesulphonate 4-chlorobenzenesulfonyl chloride benzene(4-chloro-3-nitro-phenyl)-(3-nitro-phenyl)-sulfone p-hydroxyphenyl p-tolyl sulfone 3-(4-chlorophenylsulfonyl)-1-nitrobenzene -4-ol4'-Phenylsulfonyl-3,5-di-tert-butyl-1,1'-biphenyl-4-ol

合成工艺路线路线简述

  • 合成目标产物 Sulfenone 主要起始原料 Iodobenzene And Sodium 4-Chlorobenzene Sulfinate
  • 98-60-2 = 80-00-2
    反应条件:1.1 Catalysts: Trifluoromethanesulfonic Acid; 24 H,160 °C
    标题:Triflic-Acid-Catalyzed Friedel-Crafts Reaction For The Synthesis Of Diaryl Sulfones
    作者:Falconnet,Alban; Arndt,Jan-Dirk; Hashmi,A. Stephen K.; Schaub,Thomas
    参考文献:European Journal Of Organic Chemistry 日期:2022 卷标:2022(26)]

    873-55-2 + 46449-60-9 + 37181-39-8 = 80-00-2
    反应条件:1.1 Solvents: Dimethylformamide; 24 H,90 °C
    标题:Metal-Free Synthesis Of Diaryl Sulfones From Arylsulfinic Acid Salts And Diaryliodonium Salts
    作者:Umierski,Natalie; Manolikakes,Georg
    参考文献:Organic Letters 日期:2013 卷标:15(1) 页码:188-191]

    98-80-6 + 637-87-6 = 80-00-2
    反应条件:1.1 Reagents: 1,4-Diazoniabicyclo[2.2.2]Octane,1,4-Disulfino-,Bis(Inner Salt) Catalysts: Iron Oxide (Fe3O4),1-[2-(Methylthio)Phenyl]Ethanone (Reaction Products With 3-(Trimethoxysilyl)Propylamine,Silica Functionalized),Silica,Aminopropyltrimethoxysilane (Reaction Products With O-(Methylthio)Acetophenone,Silica Functionalized),Cu2+ Solvents: Dimethylformamide; 10 H,140 °C
    标题:Fabrication And Characterization Of Copper (Ii) Complex Supported On Magnetic Nanoparticles As A Green And Efficient Nanomagnetic Catalyst For Synthesis Of Diaryl Sulfones
    作者:Abdelbasset,Walid Kamal; Mohsen,Ahmed M.; Kadhim,Mustafa M.; Alkaim,Ayad F.; Fakri Mustafa,Yasser
    参考文献:Polycyclic Aromatic Compounds 日期:2023 卷标:43(5) 页码:4032-4044]

    4547-68-6 = 80-00-2
    反应条件:1.1 Reagents: Trifluoromethanesulfonic Acid Solvents: Dichloromethane; 3 H,Rt1.2 Reagents: Water; Rt
    标题:Regiospecific Cleavage Of S-N Bonds In Sulfonyl Azides: Sulfonyl Donors
    作者:Zhang,Zhiguo; Wang,Songnan; Zhang,Yong; Zhang,Guisheng
    参考文献:Journal Of Organic Chemistry 日期:2019 卷标:84(7) 页码:3919-3926]

    591-50-4 + 14752-66-0 = 80-00-2
    反应条件:1.1 Catalysts: Cupric Acetate,2747892-13-1 Solvents: Water; 7 H,100 °C
    标题:Interfacing Sugar-Based Surfactant Micelles And Cu Nanoparticles: A Nanoreactor For C-S Coupling Reactions In Water
    作者:Ge,Xin; Song,Weili; He,Xi; Yang,Jinguo; Qian,Chao; Et Al
    参考文献:Green Chemistry 日期:2021 卷标:23(17) 页码:6322-6329]

    13343-26-5 = 80-00-2
    反应条件:1.1 Reagents: Oxygen Solvents: Diethylene Glycol Dibutyl Ether; Rt; 20 H,150 °C
    标题:Selective Oxidation Of (Hetero)Sulfides With Molecular Oxygen Under Clean Conditions
    作者:Liu,Kai-Jian; Deng,Ji-Hui; Yang,Jie; Gong,Shao-Feng; Lin,Ying-Wu; Et Al
    参考文献:Green Chemistry 日期:2020 卷标:22(2) 页码:433-438]

    873-55-2 + 637-87-6 = 80-00-2
    反应条件:1.1 Reagents: Potassium Acetate Catalysts: Glucosamine Hydrochloride,Cuprous Iodide Solvents: Dimethyl Sulfoxide,Water; 24 H,Rt -> 100 °C
    标题:D-Glucosamine As A Green Ligand For Copper Catalyzed Synthesis Of Aryl Sulfones From Aryl Halides And Sodium Sulfinates
    作者:Yang,Ming; Shen,Hongyun; Li,Yuanyuan; Shen,Chao; Zhang,Pengfei
    参考文献:Rsc Advances 日期:2014 卷标:4(50) 页码:26295-26300]

    13343-26-5 = 80-00-2
    反应条件:1.1 Reagents: Sodium Bromate Catalysts: 1-Butyl-3-Methylimidazolium Hydrogen Sulfate Solvents: Water; 20 Min,80 °C
    标题:The Highly Selective Metal-Free Oxidation Of Sulfides,Tellurides And Phosphines Using Sodium Bromate In The Presence Of Recyclable Ionic Liquid [bmim]Hso4,At 80 °.
    作者:Rajeswari,M.; Lumb,Anshika; Khurana,Jitender M.
    参考文献:Journal Of Chemical Research 日期:2016 卷标:40(7) 页码:442-444]

    = 80-00-2
    反应条件:1.1 Catalysts: Indium Triflate1.2 Reagents: Hydrochloric Acid Solvents: Dichloromethane,Water
    标题:Indium-Catalyzed Aryl And Alkyl Sulfonylation Of Aromatics
    作者:Frost,Christopher G.; Hartley,Joseph P.; Whittle,Alan J.
    参考文献:Synlett 日期:2001 卷标:(6) 页码:830-832]

    1142-97-8 + 88284-48-4 = 80-00-2
    反应条件:1.1 Reagents: Cesium Fluoride Solvents: Acetonitrile; 3 H,Rt
    标题:Facile Synthesis Of Diaryl Sulfones Through Arylsulfonylation Of Arynes And Thiosulfonates
    作者:Zheng,Yating; Tang,Delin; Xie,Pei; Luo,Jinyun; Cai,Zhihua; Et Al
    参考文献:Synthesis 日期:2023 卷标:55(8) 页码:1253-1259]

    14752-66-0 + 780-69-8 = 80-00-2
    反应条件:1.1 Reagents: Oxygen,Potassium Fluoride Catalysts: Dabco,Cuprous Iodide Solvents: Dimethylacetamide; 6 H,80 °C
    标题:Cu-Catalyzed Coupling Of Arylsulfinic Salts With Arylsilanes Under Mild Conditions
    作者:Yang,Xiaomin; Cao,Yanyan; Li,Enbo; Zhang,Pengmei; Hou,Zhanzhong
    参考文献:Applied Organometallic Chemistry 日期:2014 卷标:28(10) 页码:785-788]

    873-55-2 + 637-87-6 = 80-00-2
    反应条件:1.1 Reagents: Cesium Carbonate Catalysts: Copper Solvents: Dimethyl Sulfoxide; Rt; 24 H,Rt -> 110 °C
    标题:Efficient Ullmann C-X Coupling Reaction Catalyzed By A Recoverable Functionalized-Chitosan Supported Copper Complex
    作者:Liu,Xuemin; Chang,Shuo; Chen,Xinzhi; Ge,Xin; Qian,Chao
    参考文献:New Journal Of Chemistry 日期:2018 卷标:42(19) 页码:16013-16020]

    13343-26-5 = 80-00-2
    反应条件:1.1 Reagents: Aqua(N,N,N′,N′,N′′,N′′-Hexamethylphosphoric Triamide-Ko)Oxodiperoxymolybdenum Solvents: Tetrahydrofuran; 1.5 H,65 - 70 °C
    标题:Oxidation Of Chalcogenides Using The Peroxo Complex Of Molybdenum [moo(O2)2(H2O)(Hmpa)],Hmpa = Hexamethylphosphoramide
    作者:Khurana,Jitender M.; Agrawal,Arpita; Kumar,Sanjay
    参考文献:Journal Of The Brazilian Chemical Society 日期:2009 卷标:20(7) 页码:1256-1261]

    2751-25-9 + 10182-84-0 + 37181-39-8 = 80-00-2
    反应条件:1.1 Reagents: Sodium Bicarbonate Solvents: 1-Propanol; 18 H,100 °C
    标题:Base-Promoted Synthesis Of Diarylsulfones From Sulfonyl Hydrazines And Diaryliodonium Salts
    作者:Gong,Bozhen; Zhu,Haibo; Yang,Liu; Wang,Haifeng; Fan,Qiangwen; Et Al
    参考文献:Organic & Biomolecular Chemistry 日期:2022 卷标:20(17) 页码:3501-3505]

    515-42-4 + 637-87-6 = 80-00-2
    反应条件:1.1 Reagents: Potassium Carbonate Catalysts: N,N′-Dimethylethylenediamine,Cupric Acetate Solvents: Dimethyl Sulfoxide; Rt -> 110 °C; 2 H,110 °C
    标题:Mechanistic Aspects Of Copper (Ii)-Catalyzed Synthesis Of Sulfones From Sulfinate Salts And Aryl Halides Under C-S Coupling
    作者:Ge,Xin; Sun,Fengli; Liu,Xuemin; Chen,Xinzhi; Qian,Chao; Et Al
    参考文献:Molecular Catalysis 日期:2018 卷标:449 页码:72-78]

    153766-81-5 + 14752-66-0 = 80-00-2
    反应条件:1.1 Reagents: Sodium Acetate,Oxygen Catalysts: Cuprous Iodide Solvents: 1,2-Dichloroethane; 3 H,25 °C
    标题:Diaryl Sulfones Synthesis With Aryltrifluoroborates And Aryl Sulfinic Salts Under Mild Conditions
    作者:Zhang,Wei; Li,Ke; Zhao,Baoli
    参考文献:Journal Of Chemical Research 日期:2014 卷标:38(5) 页码:269-271]

    13343-26-5 = 80-00-2
    反应条件:1.1 Reagents: Oxygen Solvents: Diethylene Glycol Dibutyl Ether; 20 H,150 °C
    标题:Oxidation Of Aromatic Sulfides With Molecular Oxygen: Controllable Synthesis Of Sulfoxides Or Sulfones
    作者:Tang,Lili; Du,Kejie; Yu,Bing; He,Liangnian
    参考文献:Chinese Chemical Letters 日期:2020 卷标:31(12) 页码:2991-2992
📜苯磺酸甲酯置于三氧化硫体系中,化学反应生成 4-氯二苯砜
参考文献:Joly Et Al.,Recueil Des Travaux Chimiques Des Pays-Bas,1959,Vol. 78,P. 527,532
标题:Joly Et Al.,Recueil Des Travaux Chimiques Des Pays-Bas,1959,Vol. 78,P. 527,532

海关参考信息

专利信息


专利号:WO-2021074309-A1
优先权日:2019-10-16
标 题:1-(3-quinolyl)-3,4-dihydroisoquinoline derivatives as fungicides for combating specific phytopathogens
发明人：WEISS MATTHIAS; QUARANTA LAURA; BOU HAMDAN FARHAN; MAHAJAN ATUL; WILLIAMS SIMON; KILARU JAGADEESH; SEN INDIRA; BIERI STEPHANE; DIGGELMANN MARTIN
权利人:SYNGENTA CROP PROTECTION AG
摘要:1-(3-quinolyl)-3,4-dihydroisoquinoline derivatives of formula (I) as well as a method of combating, preventing or controlling the phytopathogens Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale), which comprises applying to the phytopathogen, to the locus of the phytopathogen, or to a plant susceptible to attack by the phytopathogen, or to propagation material thereof, a fungicidally effective amount of a 1-(3-quinolyl)-3,4-dihydroisoquinoline derivative of formula (I). The present description discloses the synthesis of exemplary compounds, formulation examples, relevant biological data (antifungal activity against Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale) when spayed on plants), as well as comparative data against three prior art compounds (e.g. pages 52 to 85; formulation examples; examples A1 to A3; table E; compounds E.01 to E.187; biological examples). Exemplary compounds are e.g.: 5-bromo-1-(8-fluoro-3-quinolyl)spiro[4H-isoquinoline-3,1'- cyclopropane] (example A1) 5-bromo-1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline (example A2) 1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline-5-carbonitrile (example A3)

专利号:WO-2021074311-A1
优先权日:2019-10-16
标题:1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives as fungicides for combating specific phytopathogens
发明人：WEISS MATTHIAS; QUARANTA LAURA; BOU HAMDAN FARHAN; MAHAJAN ATUL; WILLIAMS SIMON; KILARU JAGADEESH; BIERI STEPHANE; DIGGELMANN MARTIN
权利人:SYNGENTA CROP PROTECTION AG
摘要:1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives of formula (I) as well as a method of combating, preventing or controlling the phytopathogens Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale), which comprises applying to the phytopathogen, to the locus of the phytopathogen, or to a plant susceptible to attack by the phytopathogen, or to propagation material thereof, a fungicidally effective amount of a 1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives of formula (I). The present description discloses the synthesis of exemplary compounds, formulation examples, relevant biological data (antifungal activity against Mycosphaerella graminicola, Monographella nivalis, Fusarium culmorum and/or Gibberella zeae when spayed on plants) (e.g. pages 47 to 55; examples A1 and A2; compounds E.01 to E.17; table E). An exemplary compounds is e.g.: 3-(5-bromo-3,3-dimethyl-2,4-dihydro-1 H-isoquinolin-1-yl)-8-fluoro- quinoline (example A1)

专利号:CN-109705002-B
优先权日:2018-12-18
标 题 :A kind of method of photocatalytic synthesis of sulfur sulfone compound

专利号:US-2004138433-A1
优先权日:2001-03-12
标 题 :Metal bis-triflimide compounds and methods for synthesis of metal bis-triflimide compounds

专利号:MX-2007011815-A
优先权日:2005-03-25
标题 :ELECTROCHEMICAL UNLOCK SOLUTION FOR ELECTROCHEMICAL SYNTHESIS OF OLIGOMEROS IN AN ARRANGEMENT OF ELECTRODES.

专利号:US-6998497-B2
优先权日:2001-03-12
标 题:Metal bis-triflimide compounds and methods for synthesis of metal bis-triflimide compounds

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主要参考文献

[参考文献]: Robert J. Perry, Et Al. Palladium-Catalyzed Carbonylation And Coupling Reactions Of Aryl Chlorides And Amines. J Org Chem. 1996 Oct 18;61(21):7482-7485.

合成参考文献


摘要:World Review of Pest Control., 9(119), 1970
摘要:Spencer, E.Y. Guide to the Chemicals Used in Crop Protection. 6th ed. Publication 1093, Research Institute, Agriculture Canada, Ottawa, Canada: Information Canada, 1973., p. 117
摘要:Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. C-441
摘要:White-Stevens, R. (ed.). Pesticides in the Environment: Volume 1, Part 1, Part 2. New York: Marcel Dekker, Inc., 1971., p. 116
摘要:Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 817
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