CAS: 766-97-2; 1-Ethynyl-4-Methylbenzene

该化合物是一种有机化合物,其特征是其碱性功能组,其特点是在乙炔组的副位置上,一个以甲基组替代的苯环,其代之以相对于乙炔组的副位置.其分子式为C10H10, 其线性结构是乙炔细胞中的碳原子之间的三重结合造成的.该化合物一般是一种无色的黄色液体,具有独特的芳香味.该化合物在水中是不可溶的,但在乙醇和乙醇等有机溶剂中是可溶的.4-甲基苯乙炔因其在有机合成中的应用而闻名,特别是在通过混合和聚合等反应形成更为复杂的分子方面.此外,由于苯环与烷的交融,它具有有趣的电子特性,因此成为材料科学和有机电子学研究的一个课题.在处理该化合物时,应采取安全防范措施,因为如果吸入或吸收,则可能对健康造成危害.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号624-31-7 对碘甲苯 | CAS号471-25-0 丙炔酸 | CAS号4186-14-5 三甲基(对甲苯乙炔)硅烷 | CAS号1066-54-2 三甲基硅基乙炔 | CAS号33458-08-1 1-(1,2-dibromoe... | CAS号122-00-9 对甲基苯乙酮 | CAS号4301-14-8 乙炔基溴化镁 | CAS号60512-56-3 1-(2,2-二溴乙烯)-4-甲基苯 | CAS号79756-91-5 2-methyl-4-(4-m... | CAS号106-38-7 对溴甲苯 | CAS号37009-57-7 5-(4-methylphen... | CAS号55-21-0 苯甲酰胺 | CAS号4714-21-0 4-甲基二苯乙烯 | CAS号1505-50-6 3-(4-甲苯)丙酸 | CAS号938-94-3 2-(4-甲基苯基)丙酸 | CAS号33491-04-2 1-(chloroethyny... | CAS号4974-59-8 2,2-二氯-4'-甲基苯乙酮 | CAS号75348-68-4 α.β-dichloro-4-...

合成工艺路线路线简述

  • 合成目标产物 4-Ethynyltoluene 主要起始原料 (4-Methylphenylethynyl)Trimethylsilane
  • (文献来源)合成步骤主要原料 (4-Methylphenylethynyl)Trimethylsilane
4-Methylcinnamic Acid置于potassium Carbonate体系中,用 氯仿,二甲基亚砜 作为反应溶剂,化学反应 12.0H,反应生成 4-甲苯基乙炔
参考文献:使用k2Co3 / Dmso系统方便地从抗3-芳基-2,3-二溴丙酸合成末端炔烃
标题:使用k2Co3 / Dmso系统方便地从抗3-芳基-2,3-二溴丙酸合成末端炔烃
摘要:在dmso和k 2 Co 3的存在下,开发了一种方便,有效且普遍适用的方法,用于从抗3-芳基-2,3-二溴丙酸合成末端炔烃.
DOI:10.1002/cjoc.201180402

海关参考信息

专利信息


专利号:US-6350875-B1
优先权日:1999-08-16
标 题:Synthesis of cyclooctatetraene derivatives and their use as electron transporters in organic light emitting diodes
发明人:WEBER WILLIAM P; LU PING; THOMPSON MARK E; HONG HAIPING
权利人:UNIV SOUTHERN CALIFORNIA
摘要:The synthesis of asymmetric tetrasubstituted cyclooctatetraenes (“COTsâ€?) and the use of said compounds in organic light emitting diodes is reported, wherein said COTs represent a class of wide gap electron transporters that are readily deposited in vacuum.

专利号:WO-2018217538-A1
优先权日:2017-05-23
标题 :Synthesis of substituted acridines
发明人:FORT ERIC H; JAYE JOSEPH A; MCCORMICK GRANT M; BERGER KRISTEN E
权利人:UNIV OF ST THOMAS
摘要:Disclosed is a method of making substituted acridines. The method includes the step of reacting a bis(halophenyl) amine with an alkyne for a time and at a temperature to yield a substituted acridine.

专利号:US-7109377-B2
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
发明人:SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
权利人:HARVARD COLLEGE
摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

专利号:US-8835658-B2
优先权日:2012-12-28
标 题:Asymmetric synthesis of norcantharidin analougus by alkynylation of oxabenzonorbornadienes and their anticancer activities
发明人:CHAN ALBERT SUN-CHI; FAN BAOMIN; WANG JUN; LIN CHENGYUAN; HUANG CHAO; YANG QINGJING; XU JIANBIN; BIAN ZHAOXIANG; LU AIPING; HU JUN
权利人:UNIV HONG KONG BAPTIST; UNIV YUNNAN NATIONALITIES
摘要:The present invention relates to a type of norcantharidin analogues and a method to synthesis such norcantharidin analogues by transition metal-catalyzed alkynylation of 7-oxabenzonorbornadienes. The present invention also relates to the use of such norcantharidin analogues in manufacture of a medicament for the treatment of cancer tumors.

专利号:US-7321044-B2
优先权日:2001-10-12
标题 :Synthesis of oxygen-substituted benzocycloheptenes as valuable intermediate products for the production of tissue-selective estrogens
发明人:PLATZEK JOHANNES; BECKMANN WOLFGANG; GEISLER JENS; KIRSTEIN HOLGER; NIEDBALLA ULRICH; OTTOW ECKHARD; RADAU SIGMAR; SCHULZ CLAUDIA; WESSA THOMAS
权利人:SCHERING AG
摘要:The invention relates to intermediate products and a new process for the production of benzocycloheptene C. n n n n n n n n n n The process for the production of its new intermediate products according to the invention starts from economical starting materials, provides the intermediate stages in high yields and high purity, without chromatographic purification steps, and allows production on an industrial scale.

专利号:US-8268936-B2
优先权日:2005-01-04
标题:Synthesis of hybrid block copolymers and uses thereof
发明人:BREITENKAMP KURT; SILL KEVIN N
权利人:BREITENKAMP KURT; SILL KEVIN N; INTEZYNE TECHNOLOGIES INC
摘要:The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and methods of preparing the same.
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合成参考文献


摘要:Merino, P., Science of Synthesis, (2010) 45, 302.
摘要:Abou-Hadeed, K.; Hansen, H.-J., Science of Synthesis, (2010) 45, 346.
摘要:Aguilar, E.; López, L. A., Science of Synthesis Knowledge Updates, (2014) 2, 129.
摘要:Weibel, J.-M.; Blanc, A.; Pale, P., Science of Synthesis Knowledge Updates, (2018) 1, 38.
摘要:Hopkinson, M. N.; Gouverneur, V., Science of Synthesis Knowledge Updates, (2011) 2, 147.
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