CAS: 74840-34-9; 4-Chloro-2-(Methylthio)Pyrimidine-5-Carboxylic Acid

该化合物是一种环状环状物,其特点是具有湿润有机化合物,其结构包括一个碳本体酸功能组和一个替代成分;甲基氟烷基化合物的存在将硫原子引入分子中,有助于其独特的化学特性.该化合物一般表现出由于碳本体酸组而在极地溶剂中具有中等溶解性,而氯和甲基氟烷基化合物群体可以影响其再活动及与其他分子的相互作用.它可能参与各种化学反应,包括核循环替代和组合反应,使其对合成有机化学和制药应用感兴趣.该化合物的结构表明潜在的生物活动,可在药物开发或农业化学研究中加以探讨.应当参考安全数据,以便处理和使用,因为卤化化合物可能会对健康造成危害.

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5909-24-0 33089-15-5 148256-82-0

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CAS号5909-24-0 4-氯-2-甲硫基嘧啶-5-羧酸乙酯

合成工艺路线路线简述

    📜4-氯-2-甲硫基嘧啶-5-羧酸乙酯置于lithium Hydrochloride Monohydrate体系中,用 四氢呋喃,水 作为反应溶剂,以85%的收率获得产物4-氯-2-甲硫基嘧啶-5-甲酸
    参考文献:C5-Substituted Pyrido[2,3-D]Pyrimidin-7-Ones As Highly Specific Kinase Inhibitors Targeting The Clinical Resistance-Related Egfrt790M Mutant
    标题:C5-Substituted Pyrido[2,3-D]Pyrimidin-7-Ones As Highly Specific Kinase Inhibitors Targeting The Clinical Resistance-Related Egfrt790M Mutant
    摘要:C5-取代的吡啶并[2,3-D]嘧啶-7-酮被发现为高效且特异的抑制剂,针对临床耐药相关的egfr L858R/t790M突变体.
    DOI:10.1039/c5Md00208G

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    专利信息


    专利号:US-8188113-B2
    优先权日:2006-09-14
    标 题 :Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
    发明人：FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C
    权利人:FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C; DECIPHERA PHARMACEUTICALS INC
    摘要:The present invention relates to novel dihydropyridopyrimidinyl, dihydronaphthyridinyl, and related compounds which are kinase inhibitors and modulator useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

    专利号:CN-109789142-A
    优先权日:2016-07-01
    标题 :Synthesis of N- (heteroaryl) -pyrrolo [3,2-D ] pyrimidin-2-amines

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    合成参考文献

    参考DOI号:10.1016/j.bmcl.2019.04.017
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