📜溴乙烷置于肼体系中,用 乙醇 作为反应溶剂,化学反应 2.0H,反应生成 乙基肼 参考文献:Pyrimido[5,4-E][1,2,4]Triazine-5,7-Diones,Processes For Preparing Them And Their Use 标题:Pyrimido[5,4-E][1,2,4]Triazine-5,7-Diones,Processes For Preparing Them And Their Use 摘要:该发明涉及嘧啶并[5,4-E][1,2,4]三嗪-5,7-二酮,其药用可接受盐及生理功能衍生物.因此,该发明涉及具有式i,1的化合物,其中基团具有给定含义,以及它们的生理耐受盐和制备它们的方法.这些化合物适用于例如作为抗糖尿病药物.
专利号:US-8877930-B2 优先权日:2009-11-04 标 题 :Continuous flow synthesis of amino alcohols using microreactors 发明人:BEDORE MATTHEW W; ZABORENKO NIKOLAY; JENSEN KLAVS F; JAMISON TIMOTHY F 权利人:BEDORE MATTHEW W; ZABORENKO NIKOLAY; JENSEN KLAVS F; JAMISON TIMOTHY F; MASSACHUSETTS INST TECHNOLOGY 摘要:The present invention provides various methods for the synthesis of chemical species in a microreactor environment. In some cases, reaction products of the present invention may be valuable as intermediates and/or products in pharmaceutical and polymer research. For example, the method may involve the synthesis of amino alcohols within a microchannel. Embodiment described herein may allow for reactions with significantly shorter reaction times and increased efficiency.
专利号:WO-2024182268-A1 优先权日:2023-02-27 标 题 :Liquid phase peptide support synthesis of peptides and peptidomimetics 发明人:HAN AMY 权利人:REGENERON PHARMA 摘要:The present invention provides compounds useful as support for liquid phase organic synthesis e.g., liquid phase organic synthesis of peptides and peptidomimetics. In one aspect, the present invention provides a compound having a structure of Formula (I) where R1, R2, R3, m, and n are as described herein and methods of making and using same.
专利号:US-2016280691-A1 优先权日:2013-11-07 标 题 :Triazole intermediates useful in the synthesis of protected n-alkyltriazolecarbaldehydes 发明人:HENDERSON MARK 权利人:BIOMARIN PHARM INC 摘要:Described herein are compounds and methods of making such compounds useful in the synthesis of protected N-alkyl-triazolecarbaldehydes.
专利号:US-9221821-B2 优先权日:2012-06-05 标题:Methods for the synthesis of 1,3-substituted aminouracils and other xanthine-related compounds 发明人:DIEP NHUT; KALYAN YURIY B 权利人:FOREST LAB HOLDINGS LTD; FOREST LAB HOLDINGS LTD 摘要:Methods for the synthesis of disubstituted aminouracils and xanthine and/or xanthine-related compounds are provided.
专利号:EP-1641729-B1 优先权日:2003-07-09 标题:Use of functionalized onium salts as a soluble support for organic synthesis 发明人:VAULTIER MICHEL; GMOUH SAID; HASSINE FATIMA 权利人:CENTRE NAT RECH SCIENT; UNIV RENNES 摘要:The invention relates to the use of a onium salt functionalized by at least one organic function, as a soluble support, in the presence of at least one organic solvent, for organic synthesis of a molecule, in a homogenous phase, by at least one transformation of said organic function. The onium salt enables the synthesized molecule to be released. The onium salt is present in liquid or solid form at room temperature and corresponds to formula A1+, X1-, wherein A1+ represents a cation and X1- represents an anion.
专利号:US-9777022-B2 优先权日:2012-10-02 标题 :Process for the preparation of macrocyclic polyazacarboxylate ligands and chelates 发明人:MOORE DENNIS A; RAJAGOPALAN RAGHAVAN 权利人:MALLINCKRODT LLC; GUERBET SA 摘要:The present disclosure relates generally to a process for the synthesis of 1,4,7,10-tetraazacyclododecane ligands, chelates, and derivatives thereof. In particular, the present disclosure is directed to a process for the synthesis of 1,4,7,10-tetraaza-1,4,7,10-tetrakis(carboxymethyl)cyclododecane (DOTA) ligands, corresponding DOTA-metal chelates, and various derivatives thereof.
摘要:Götzinger, A. C.; Müller, T. J. J., Science of Synthesis Knowledge Updates, (2017) 3, 7. 摘要:Götzinger, A. C.; Müller, T. J. J., Science of Synthesis Knowledge Updates, (2017) 3, 5. 摘要:R. L. Hinman. J. Org. Chem. 23, 1587 (1958).