专利号:US-9242925-B2 优先权日:2011-08-29 标题:Versatile and stereospecific synthesis of γ,δ-unsaturated amino acids by Wittig reaction 发明人:JUGE SYLVAIN; BAYARDON JEROME; REMOND EMMANUELLE; ONDEL-EYMIN MARIE-JOELLE 权利人:JUGE SYLVAIN; BAYARDON JEROME; REMOND EMMANUELLE; ONDEL-EYMIN MARIE-JOELLE; CENTRE NAT RECH SCIENT; UNIV BOURGOGNE 摘要:The γ,δ-unsaturated α-amino acids of general formula (I). Also, a versatile process for the stereospecific synthesis of said compounds of formula (I), involving a Wittig reaction. Further, intermediate products of general formulae (II) and (III), as shown below, which are involved in the synthesis of compounds (I). n n n n n n n n n n n n Compounds of general formula (I) may be useful as therapeutic substances, or as reagents or intermediates for fine chemistry.
专利号:US-9597327-B2 优先权日:2005-05-25 标 题:Synthesis of (R)-N-methylnaltrexone 发明人:DOSHAN HAROLD D; PEREZ JULIO 权利人:PROGENICS PHARM INC 摘要:This invention relates to stereoselective synthesis of R-MNTX and intermediates thereof, pharmaceutical preparations comprising R-MNTX or intermediates thereof and methods for their use.
专利号:US-9145368-B2 优先权日:2011-12-15 标 题 :Organocatalytic synthesis of chiral pyrazolidines and their analogues 发明人:KUMAR BOOPATHI SENTHIL; VENKATARAMASUBRAMANIAN VAITHIYANATHAN; SUDALAI ARUMUGAM 权利人:COUNCIL SCIENT IND RES 摘要:Disclosed herein is a highly enantio- (75 to 98% ee) and diastereoselective (99 to 100% de) synthesis of functionalized pyrazolidines via tandem a-amination-Corey Chaykovsky reaction of alpha unsubstituted aldehydes.
专利号:US-9233925-B2 优先权日:2012-03-07 标 题:Process for preparation of roflumilast 发明人:CHEN YI-JING; PIKUL STANISLAW; KUO SHEN-CHUN; CHU GUO-DONG 权利人:SCINOPHARM CHANGSHU PHARMACEUTICALS LTD 摘要:The present invention provides novel processes for the preparation of N-substituted benzamides having the formula VIc: n nIn some embodiments, the invention provides a process for preparation of roflumilast and other pharmaceutically active species. Novel compounds, including intermediates for the synthesis of roflumilast, are also provided.
专利号:US-7674904-B2 优先权日:2005-05-25 标 题 :Synthesis of R-N-methylnaltrexone
专利号:US-2007099946-A1 优先权日:2005-05-25 标 题:Synthesis of R-N-methylnaltrexone