CAS: 54745-92-5; Quinoxaline-2-Carbonyl Chloride

该化合物是有机化合物,其特点是存在一种五角星环结构和一个丙基氯功能组,这种化合物一般是无色的,光黄色液体或固态,视其纯度和储存条件而定;以其反应性而著称,特别是由于乙基氯的活性,它很容易发生核生殖替代反应;这使它成为有机合成中的宝贵中间体,特别是在制作各种衍生物,包括氨化物和酯时;该化合物还用于合成药品和农用化学品;然而,必须谨慎地处理二克五氯,因为它可以是腐蚀性的,在水或水分反应时可能会释放有害气体;在与该化学品合作时,适当的安全防范措施,包括使用个人防护设备和在通风良好的地区工作,至关重要.

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上下游产品

CAS号879-65-2 2-喹喔啉羧酸 | CAS号4711-06-2 (1R,2S,3R)-1-qu... | CAS号7065-23-8 2-喹喔啉羧酸乙酯 | CAS号226878-01-9 NPS 2390 | CAS号1865-11-8 喹喔啉-2-甲酸甲酯 | CAS号212790-31-3 CP-481715 | CAS号7066-32-2 N-benzyl-3,6,6-... | CAS号925436-46-0 4-[[6-[2-[(2-喹噁... | CAS号54571-06-1 喹喔啉-2-甲酰肼 | CAS号5182-90-1 2-喹喔啉甲酰胺

合成工艺路线路线简述

    📜(1R,2S,3R)-(2-喹喔啉基)-1,2,3,4-丁烷四醇置于sodium Hydroxide,氯化亚砜,双氧水体系中,化学反应生成 2-喹喔啉甲酰氯
    参考文献:Maurer; Boettger,Chemische Berichte,1938,Vol. 71,P. 1383,1390
    标题:Maurer; Boettger,Chemische Berichte,1938,Vol. 71,P. 1383,1390

    海关参考信息

    专利信息


    专利号:WO-9931506-A9
    优先权日:1997-12-18
    标题:Parallel solution phase synthesis of lactams
    发明人:CWI CYNTHIA LYNN; SCOTT WILLIAM LEONARD
    权利人:LILLY CO ELI; CWI CYNTHIA LYNN; SCOTT WILLIAM LEONARD
    摘要:The present invention provides a parallel solution phase process for making combinatorial arrays of lactam derivatives which are useful for screening for therapeutically useful compounds.

    专利号:WO-9931506-A1
    优先权日:1997-12-18
    标题 :Parallel solution phase synthesis of lactams

    专利号:US-7648986-B2
    优先权日:2002-01-10
    标题:Substituted thieno[3,2-D]pyrimidines as Rho kinase inhibitors
    发明人:NAGARATHNAM DHANAPALAN; KHIRE UDAY; ASGARI DAVOUD; SHAO JIANXING; LIU XIAO-GAO; WANG CHUNGUANG; HART BARRY; WEBER OLAF; LYNCH MARK; ZHANG LEI; WANG LEI
    权利人:BAYER HEALTHCARE LLC
    摘要:Disclosed are compounds and derivatives thereof their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.

    专利号:TW-201206439-A
    优先权日:2010-07-15
    标 题:Synthesis and anticancer activity of aryl and heteroaryl-quinolin derivatives

    专利号:RU-2195454-C2
    优先权日:1996-10-18
    标 题 :Derivatives of anthranilic acid, methods of their synthesis and pharmaceutical composition based on thereof

    专利号:EP-1370553-B1
    优先权日:2001-03-23
    标 题 :Rho-kinase inhibitors
    发明人:NAGARATHNAM DHANAPALAN; ASGARI DAVOUD; SHAO JIANXING; LIU XIAO-GAO; KHIRE UDAY; WANG CHUNGUANG; HART BARRY; BOYER STEPHEN; WEBER OLAF; LYNCH MARK; BANKSTON DONALD
    权利人:BAYER AG
    摘要:Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1055/s-0032-1316639
    摘要:Toshima K. Design, Synthesis and Evaluation of Light-Activatable Organic Molecules that Target-Selectively Degrade DNA, Proteins and Carbohydrates; an Interdisciplinary Challenge for a Synthetic Organic Chemist. Synlett. 2012 Aug 03;23(14):2025–52. doi: 10.1055/s-0032-1316639.
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