专利号:WO-9931506-A9 优先权日:1997-12-18 标题:Parallel solution phase synthesis of lactams 发明人:CWI CYNTHIA LYNN; SCOTT WILLIAM LEONARD 权利人:LILLY CO ELI; CWI CYNTHIA LYNN; SCOTT WILLIAM LEONARD 摘要:The present invention provides a parallel solution phase process for making combinatorial arrays of lactam derivatives which are useful for screening for therapeutically useful compounds.
专利号:WO-9931506-A1 优先权日:1997-12-18 标题 :Parallel solution phase synthesis of lactams
专利号:US-7648986-B2 优先权日:2002-01-10 标题:Substituted thieno[3,2-D]pyrimidines as Rho kinase inhibitors 发明人:NAGARATHNAM DHANAPALAN; KHIRE UDAY; ASGARI DAVOUD; SHAO JIANXING; LIU XIAO-GAO; WANG CHUNGUANG; HART BARRY; WEBER OLAF; LYNCH MARK; ZHANG LEI; WANG LEI 权利人:BAYER HEALTHCARE LLC 摘要:Disclosed are compounds and derivatives thereof their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
专利号:TW-201206439-A 优先权日:2010-07-15 标 题:Synthesis and anticancer activity of aryl and heteroaryl-quinolin derivatives
专利号:RU-2195454-C2 优先权日:1996-10-18 标 题 :Derivatives of anthranilic acid, methods of their synthesis and pharmaceutical composition based on thereof
专利号:EP-1370553-B1 优先权日:2001-03-23 标 题 :Rho-kinase inhibitors 发明人:NAGARATHNAM DHANAPALAN; ASGARI DAVOUD; SHAO JIANXING; LIU XIAO-GAO; KHIRE UDAY; WANG CHUNGUANG; HART BARRY; BOYER STEPHEN; WEBER OLAF; LYNCH MARK; BANKSTON DONALD 权利人:BAYER AG 摘要:Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
参考文献:10.1055/s-0032-1316639 摘要:Toshima K. Design, Synthesis and Evaluation of Light-Activatable Organic Molecules that Target-Selectively Degrade DNA, Proteins and Carbohydrates; an Interdisciplinary Challenge for a Synthetic Organic Chemist. Synlett. 2012 Aug 03;23(14):2025–52. doi: 10.1055/s-0032-1316639.