CAS: 51168-26-4; 2-Methoxy-1,7,9-Trimethyl-7,9-Dihydro-1H-Purine-6,8-Dione

该化合物是化学化合物,其特点是结构复杂,包括一个用甲氧基和甲基组来改造的纯碱基;该化合物的特点是一个2位置的甲氧组(-OCH3),以及1,7和9个纯环的三组甲基组,以及6和8位置的碳基组,有助于其二元分类;这些功能组的存在影响其溶性,稳定性和再活性;通常,纯衍生物因其生物意义而闻名,经常在核酸结构和功能以及各种生物化学途径中发挥作用;该复合物可能具有潜在亚基或抑制剂的特性,并且由于其结构与自然发生的核细胞基地相似,还可能对药理学或生物化学产生影响;其化学文摘社编号为51168-264,可以在化学数据库和文献中准确识别.

结构式图片

上下游产品

Liberine 56119-16-5
1,7,9-Trimethyl-7,9-Dihydro-3H-Purine-2,6,8-Trione 55441-64-0
7,9-二氢-7,9-二甲基-1H-嘌呤-2,6,8(3H)-三酮 7,9-Dimethyluric Acid 19039-41-9

合成工艺路线路线简述

  • 合成目标产物 2-Methoxy-1,7,9-Trimethylpurine-6,8-Dione 主要起始原料 1H-Purine-6,8-Dione, 7,9-Dihydro-2-Methoxy-1,7-Dimethyl- And Iodomethane
  • (文献来源)合成步骤主要原料 1H-Purine-6,8-Dione, 7,9-Dihydro-2-Methoxy-1,7-Dimethyl- 和 Iodomethane
📜6-氨基-2-甲氧基-3-甲基-4(3H)-嘧啶酮置于n-氯代丁二酰亚胺,三乙胺体系中,用 四氢呋喃,甲醇,乙腈 作为反应溶剂,化学反应 35.0H,反应生成 咖啡因杂质
参考文献:三种甲基尿酸类化合物的制备方法,中间体及中间体的制备方法
标题:三种甲基尿酸类化合物的制备方法,中间体及中间体的制备方法
摘要:本发明提供了三种可从茶树等植物中提取获得的,具有抗抑郁,镇静催眠,抗炎镇痛,减轻肝细胞的应激性损伤和提高运动能力等功效的化合物的制备方法,及其中间体和中间体的制备方法.本发明操作简便,安全性高,原子经济性高,三废少;原辅料廉价易得,毒性低,安全稳定;反应条件温和,杂质少,收率高;本发明通过结晶纯化产品,避免柱层析,操作简单易行,工艺稳定,易于控制,反应后处理方便,可以经济方便地用于工业化生产.

海关参考信息

专利信息


专利号:US-2024317750-A1
优先权日:2021-06-24
标 题 :An Efficient Process for the Synthesis of Methylliberine and Polymorphs Thereof
发明人:KANUMURU RAHUL RAJU; SHAJI GEORGE KOCHUMALAYIL; VANA MURALI MOHANARAO; SURANENI RAVIKUMAR; ANINDYA SIL
权利人:FERTIS INDIA PVT LTD
摘要:The present invention discloses a synthetic procedure for the preparation of Methylliberine and its polymorphs thereof in a simple and efficient manner.

专利号:WO-2022229983-A1
优先权日:2021-04-29
标题:Sugar esters and sugar alcohol esters of short chain fatty acids and compositions thereof
发明人:KANUMURU RAHUL RAJU; SHAJI GEORGE KOCHUMALAYIL; ANINDYA SIL; SURANENI RAVIKUMAR; GARUDADRI LAKSHMI PRASANNA KUMAR
权利人:FERTIS INDIA PVT LTD
摘要:The present invention discloses compositions comprising sugar esters and sugar alcohol esters of short chain fatty acids and their use in pest management. These compositions possess antiviral, antimicrobial, insecticidal, pesticidal and herbicidal properties and their potential use in controlling, Lepidoptera, Hemiptera and Thysanoptera insects, Tomato spotted wilt viruses, Tobacco mosaic viruses. The present invention also dicloses compositions of sugar esters and sugar alcohol esters of short chain fatty acids as potential agents for treating oral and dermatological problems of microbial origin. The present invention further discloses the synthesis of novel sugar esters and sugar alcohol esters of short chain fatty acids.

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献


1: La Monica MB, Raub B, Malone K, Hartshorn S, Grdic J, Gustat A, Sandrock J. Methylliberine Ingestion Improves Various Indices of Affect but Not Cognitive Function in Healthy Men and Women. Nutrients. 2023 Oct 24;15(21):4509. doi: 10.3390/nu15214509.
2: Murbach TS, Glávits R, Endres JR, Clewell AE, Hirka G, Vértesi A, Béres E, Szakonyiné IP. A Toxicological Evaluation of Methylliberine (Dynamine®). J Toxicol. 2019 Oct 27;2019:4981420. doi: 10.1155/2019/4981420.
3: Cintineo HP, Bello ML, Chandler AJ, Cardaci TD, McFadden BA, Arent SM. Effects of caffeine, methylliberine, and theacrine on vigilance, marksmanship, and hemodynamic responses in tactical personnel: a double-blind, randomized, placebo-controlled trial. J Int Soc Sports Nutr. 2022 Aug 18;19(1):543-564. doi: 10.1080/15502783.2022.2113339.

合成参考文献


参考文献:10.2741/1339
摘要:Mazzafera P. Catabolism of caffeine in plants and microorganisms. Front Biosci. 2004 May 01;9():1348–59. doi: 10.2741/1339.
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