CAS: 4599-60-4; Penimepicycline

该化合物是属于四环类的半合成抗生素,其特征是其广泛频谱抗菌活动,使其对各种抗菌性细菌和抗菌性细菌有效,该化合物展示了一种独特的结构,加强了其在酸性环境中的稳定性,从而可以更好地吸收到肠胃道中; Penimephepilcyine通过抑制细菌蛋白合成,特别是约束于30-S的肋骨子细胞,从而防止了翻译过程;这一行动机制有助于其治疗各种感染的效果;此外,人们注意到它有可能用于治疗诸如丙烯和呼吸道感染等疾病;然而,它与其他四环虫病一样,可能会造成副作用,包括胃肠扰动和光敏锐;它的使用还取决于抗生素抗药性因素,需要谨慎的处方做法; 总的来说, 五溴二苯醚是抗生素武库中的一个重要选择,特别是在细菌感染的情况下.

英文名称Penimepicycline
中文名称青哌环素
IUPAC名称(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-N-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenoxyacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
CAS编号4599-60-4
FDA UNII编号:3RGQ4B6E87
分子式:C45H56N6O14S分子量:937.03
产品CID: 1460418

相似结构搜索
InChIKey: MEGKRPMNPGTIIG-VNYBMUHKSA-N
1S/C29H38N4O9.C16H18N2O5S/c1-28(41)15-5-4-6-18(35)19(15)23(36)20-16(28)13-17-22(31(2)3)24(37)21(26(39)29(17,42)25(20)38)27(40)30-14-33-9-7-32(8-10-33)11-12-34;1-16(2)12(1
计算化学: 氢键受体数18.0氢键供体数9.0可旋转键数11.0

MSDS等安全信息

合成工艺路线路线简述

海关参考信息

2901210000-乙烯
2901220000-丙烯
2902500000-苯乙烯
2902600000-乙苯
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专利信息

专利号:US-10472663-B2
优先权日:2015-01-21
标题:Procedure for the rapid determination of bacterial susceptibility to antibiotics that inhibit protein synthesis
发明人：FERNÃ?NDEZ GARCÃ?A JOSÃ‰ LUIS; GOSÃ?LVEZ BERENGUER JAIME; BOU ARÃ‰VALO GERMÃ?N; TAMAYO NOVAS MARIA; SANTISO BRANDARIZ REBECA; OTERO FARIÃ‘A FÃ?TIMA MARÃ?A
权利人:ABM TECH LLC
摘要:The present invention relates to a method for the rapid evaluation of bacterial susceptibility or non-susceptibility of bacteria to antibiotics that inhibit protein synthesis. The rationale is to identify bacterial responses that depend or are influenced by protein synthesis. If this response is prevented or reduced by the antibiotic that inhibits the protein synthesis, the bacteria are susceptible to this antibiotic. Otherwise, if the response keeps similar despite the incubation with the antibiotic, the bacteria are not susceptible or resistant to this antibiotic. These responses could be determined at the DNA lev-el, cell wall level, morphological level or any other experimental approach, including metabolic, bio-chemical, physiological or genetic processes.

专利号:ES-2710679-T3
优先权日:2015-01-21
标题:Procedure for the rapid determination of bacterial susceptibility to antibiotics that inhibit the synthesis of proteins

专利号:JP-2010532759-A
优先权日:2007-07-06
标题 :Method for the synthesis of substituted tetracycline compounds

专利号:EP-3048174-A1
优先权日:2015-01-21
标题:Procedure for the rapid determination of bacterial susceptibilty to antibiotics that inhibit protein synthesis

专利号:EP-3048174-B1
优先权日:2015-01-21
标题 :Procedure for the rapid determination of bacterial susceptibility to antibiotics that inhibit protein synthesis

专利号:US-2016208307-A1
优先权日:2015-01-21
标题:Procedure for the rapid determination of bacterial susceptibility to antibiotics that inhibit protein synthesis