CAS: 38614-36-7; 2-Methyl-1-Propenylmagnesium Bromide

该化合物是有机合成中常用的一种灰色剂,用于核循环添加和组合反应;四氢呋喃(THF)中的0.5M浓度确保了最佳溶性与回活性,使将2-甲基-1-丙基酰胺组引入目标分子成为方便的选择;这种试剂对于制备三级酒精,氯酮和其他功能化化合物特别宝贵;在惰性条件下,高浓油的稳定性使得能够进行可靠的处理和储存;这种溶液的高度纯度和连续回活性提高了其在研究和工业应用中的效用,特别是在精细化学和制药合成中;建议在水性条件下进行适当处理以保持性能.

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    专利信息


    专利号:US-2011130567-A1
    优先权日:2009-06-03
    标题 :Steroselective synthesis of certain trifluoromethyl-substituted alcohols
    发明人:FANDRICK DANIEL R; REEVES JONATHAN T; SONG JINHUA J; TAN ZHULIN; QU BO; YEE NATHAN K; RODRIGUEZ SONIA
    权利人:BOEHRINGER INGELHEIM INT
    摘要:A process for stereoselective synthesis of a compound of Formula (X) n n n n n n n n n n wherein:n R 1 is an aryl group substituted with one to three substituent groups,n wherein each substituent group of R 1 is independently C 1 -C 5 alkyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, halogen, carboxy, cyano, or trifluoromethyl,n wherein each substituent group of R 1 is optionally independently substituted with one to three substituents selected from C 1 -C 3 alkyl, C 1 -C 3 alkoxy, phenyl, and alkoxyphenyl; n n R 2 and R 3 are each independently C 1 -C 5 alkyl; R 4 is C 1 -C 5 alkyl optionally independently substituted with one to three substituent groups,n wherein each substituent group of R 4 is independently C 1 -C 3 alkyl, hydroxy, halogen, amino, or oxo; and n R 5 is a heteroaryl group substituted with one to three substituent groups,n wherein each substituent group of R 5 is independently C 1 -C 5 alkyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, alkylsulfonylamino, aminosulfonyl, C 1 -C 5 alkylaminosulfonyl, C 1 -C 5 dialkylaminosulfonyl, halogen, hydroxy, carboxy, cyano, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, or C 1 -C 5 alkylthio wherein the sulfur atom is optionally oxidized to a sulfoxide or sulfone.

    专利号:US-2011130578-A1
    优先权日:2009-06-03
    标题 :Stereoselective synthesis of certain trifluoromethyl-substituted alcohols
    发明人:FANDRICK DANIEL R; KUZMICH DANIEL; REEVES JONATHAN T; SONG JINHUA J; TAN ZHULIN; LEE THOMAS
    权利人:BOEHRINGER INGELHEIM INT
    摘要:A process for stereoselective synthesis of a compound of Formula (X) or Formula (X′) n n n n n n n n n n wherein:n R 1 is an aryl group substituted with one to three substituent groups,n wherein each substituent group of R 1 is independently C 1 -C 5 alkyl, C 2 -C 5 alkenyl, C 2 -C 5 alkynyl, C 1 -C 5 alkoxy, C 1 -C 5 alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, C 1 -C 5 alkoxycarbonylamino, aminosulfonyl, C 1 -C 5 alkylaminosulfonyl, C 1 -C 5 dialkylaminosulfonyl, halogen, hydroxy, carboxy, cyano, trifluoromethyl, trifluoromethoxy, nitro, or C 1 -C 5 alkylthio wherein the sulfur atom is oxidized to sulfoxide or sulfone, and n R 2 and R 3 are each independently hydrogen or C 1 -C 5 alkyl.

    专利号:US-4070404-A
    优先权日:1976-03-26
    标 题:Process to 1,1-dihalo-4-methyl-1,3-pentadienes, pyrethroid insecticide intermediates
    发明人:LUPICHUK ANDREW
    权利人:FMC CORP
    摘要:1,1-Dihalo-4-methyl-1,3-pentadienes, key intermediates in the synthesis of insecticidal dihalovinylcyclopropanecarboxylates, result from the condensation of 3-methyl-1-butene with a carbon tetrahalide in the presence of a catalyst, followed by the base-induced dehydrohalogenation of the 1,1,1,3-tetrahalo-4-methylpentane resulting from the condensation.

    专利号:CN-110483289-B
    优先权日:2019-07-31
    标题:A kind of method for asymmetric synthesis of chiral alkenoate

    专利号:US-9879022-B2
    优先权日:2014-04-04
    标题:Bicyclic-fused heteroaryl or aryl compounds
    发明人:TRZUPEK JOHN DAVID; LEE KATHERINE LIN; BUNNAGE MARK EDWARD; HAN SEUNGIL; HEPWORTH DAVID; LOVERING FRANK ELDRIDGE; MATHIAS JOHN PAUL; PAPAIOANNOU NIKOLAOS; PIERCE BETSY SUSAN; STROHBACH JOSEPH WALTER; WRIGHT STEPHEN WAYNE; ZAPF CHRISTOPH WOLFGANG; GAVRIN LORI KRIM; LEE ARTHUR; ANDERSON DAVID RANDOLPH; CURRAN KEVIN JOSEPH; DEHNHARDT CHRISTOPH MARTIN; SAIAH EDDINE; GOLDBERG JOEL ADAM; WANG XIAOLUN; HUANG HORNG-CHIH; VARGAS RICHARD; LOWE MICHAEL DENNIS; PATNY AKSHAY
    权利人:PFIZER
    摘要:Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

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    合成参考文献


    摘要:Petasis, N. A., Science of Synthesis, (2010) 47, 238.
    摘要:Alonso, D. A.; Nájera, C., Science of Synthesis, (2010) 47, 468.
    摘要:Molander, G. A.; Beaumard, F., Science of Synthesis Knowledge Updates, (2013) 3, 114.
    摘要:Ipaktschi, J.; Saidi, M. R., Science of Synthesis Knowledge Updates, (2012) 4, 478.
    摘要:Wolf, C., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 891.
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