CAS: 376587-52-9; 5-Bromo-2-Iodo-3-Methylpyridine

相似化合物

22282-58-2 941294-57-1 1211542-16-3

上下游产品

CAS号3430-18-0 2,5-二溴-3-甲基吡啶

2,5-二溴-3-甲基吡啶置于乙酰氯,Sodium Iodide体系中,用 乙腈 用作溶剂,化学反应 48.0H,以84%的收率获得2-碘-3-甲基-5-溴吡啶
参考文献:机械敏感的合成离子通道
标题:机械敏感的合成离子通道
摘要:机械应力是膜蛋白检测到的普遍刺激,而合成分子则很少.受细胞膜中机械敏感离子通道的启发,产生了张力反应性跨膜多嵌段两亲物.在膜中,单跨膜两亲物分别响应于扩张和收缩张力,以减弱和加强跨膜单元的堆叠,并且通过扩大张力形成超分子通道来触发离子迁移,而在膜下,则几乎没有观测到迁移.无张力状态.相反,三跨膜两亲物对张力几乎没有光谱响应,这可能是由于跨膜单元的堆叠较单跨膜两亲物弱.尽管如此,三跨膜两亲物即使在无张力条件下也通过形成单分子通道而显示出离子传输,并且随着张力的增加,离子传输活性降低.有趣的是,这些合成系统的估计作用力与机械敏感蛋白的作用力相当.这项研究为新型机械敏感分子装置打开了大门.
Doi:10.1021/jacs.7B09515

专利信息

专利号:US-6635767-B2
优先权日:2000-05-23
标 题 :Synthesis of heteroarylamine intermediate compounds
发明人：SONG JINHUA J; YEE NATHAN K; KAPADIA SURESH R
权利人:BOEHRINGER INGELHEIM PHARMA
摘要:Disclosed are novel 2-(5-halopyridyl) and 2-(5-halopyrimidinyl) magnesium halides, processes of making and their use in the efficient synthesis in their respective 5-halo-2-substituted pyridines and pyrimidines.

专利号:US-6822093-B2
优先权日:2000-05-23
标题 :Synthesis of heteroarylamine intermediate compounds
发明人：SONG JINHUA J; YEE NATHAN K
权利人:BOEHRINGER INGELHEIM PHARMA
摘要:Disclosed are novel 2-(5-halopyridyl) and 2-(5-halopyrimidinyl) magnesium halides, processes of making and their use in the efficient synthesis in their respective 5-halo-2-substituted pyridines and pyrimidines.

专利号:US-2003135046-A1
优先权日:2000-05-23
标题 :Synthesis of heteroarylamine intermediate compounds

专利号:CA-2424916-C
优先权日:2000-05-23
标 题:Novel synthesis of heteroarylamine intermediate compounds

专利号:EP-1409460-B1
优先权日:2000-05-23
标题:Novel synthesis of heteroarylamine intermediate compounds

专利号:EP-1409460-A1
优先权日:2000-05-23
标题 :Novel synthesis of heteroarylamine intermediate compounds