CAS: 33697-81-3; 3-Chloro-4-Hydroxyphenylacetic Acid
该化合物是一种有机化合物,其特点是其芳香结构和功能组;其元体位置为氯替代物,与乙酸酸协会相比,其位置为氢氧化物;该化合物一般是白色至白色的固体,由于存在氢氧化物组,可溶解于极地溶剂中,可溶于氢结合;其化学特性受氯原子的电吸附效应影响,可影响其再活动及与生物系统的相互作用;3-Chloloo-4-水氧基乙酸可能展示生物活动,使其对制药研究感兴趣,特别是在开发反食气剂或止热剂方面;与许多有机化合物,安全和处理预防措施一样,如果采用或不适当处理,可能会造成风险.
- 英文名称3-Chloro-4-Hydroxyphenylacetic Acid
- 中文名称3-氯-4羟基苯乙酸
- IUPAC名称2-(3-chloro-4-hydroxyphenyl)acetic acid
- 其它别名2-(3-Chloro-4-Hydroxyphenyl)Acetic Acid; 2-(3-Chloro-4-Hydroxy-Phenyl)Acetic Acid; 2H6B; 2-(3-Chloro-4-Hydroxyphenyl)Aceticacid; 3-Chloro-4-Hydroxyphenylacetic Acid; 3-Chloro-4-Hydroxy-Phenylacetic Acid; 3-Chl
- CAS编号33697-81-3
- MFCD编号:MFCD00004349
- EINECS号:251-643-0
- 分子式:C8H7ClO3分子量:186.59
- 产品CID: 1333328
- 产品分类化学试剂 → 有机试剂 → 芳香酸
物理性质
MSDS等安全信息
欧盟法规
ECHA物质C&L通报REACH预注册上下游产品
CAS号156-38-7 对羟基苯乙酸 | CAS号13721-20-5 3-氯-4-甲氧基苯乙酸 | CAS号72198-15-3 3-chloro-4-hydr... | CAS号95-57-8 邻氯苯酚 | CAS号7569-58-6 2-(3-氯-4-甲氧基苯基)乙腈 | CAS号57017-95-5 3-氯-4-羟基苯乙酸甲酯 | CAS号156-38-7 对羟基苯乙酸 | CAS号870194-63-1 4-Isoxazolecarb... | CAS号496856-45-2 methyl 2-(3-chl...合成工艺路线路线简述
- 合成目标产物 3-Chloro-4-Hydroxyphenylacetic Acid 主要起始原料 2-Chlorophenol
- (文献来源)合成步骤主要原料 2-Chlorophenol
📜(3-氯-4-甲氧基苯基)乙酸置于sodium Methylate体系中,化学反应生成3-氯-4羟基苯乙酸
参考文献:Hromatka,Chemische Berichte,1942,Vol. 75,P. 123,129
标题:Hromatka,Chemische Berichte,1942,Vol. 75,P. 123,129
海关参考信息
- 2902600000-乙苯
2903919090-氯苯
2912110000-甲醛
2912120000-乙醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-6790946-B2
优先权日:1997-05-14
标题 :Synthesis of oligonucleotides
发明人：KWIATKOWSKI MAREK; LANDEGREN ULF; NILSSON MATS
权利人:QUIATECH AB
摘要:A method of preparing an immobilized oligonucleotide having a free 3′-end comprises the steps of: i) preparing an oligonucleotide attached in a first position to a solid support via its 3′-end and having a free 5′-end; ii) binding said oligonucleotide in a second position remote from the 3′-end to the solid support; and iii) selectively releasing the 3′-end of the oligonucleotide from the solid support to obta the oligonucleotide attached to the support in said second position in a reversed orientation with a free 3′-end.
专利号:US-2002051994-A1
优先权日:1997-05-14
标题 :Synthesis of oligonucleotides
专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人：ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.
专利号:EP-0983288-B1
优先权日:1997-05-14
标 题 :Synthesis of oligonucleotides
专利号:WO-9851698-A1
优先权日:1997-05-14
标题:Synthesis of oligonucleotides
专利号:EP-0983288-A1
优先权日:1997-05-14
标题:Synthesis of oligonucleotides
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Kumar R, Sadowski MC, Levrier C, Nelson CC, Jones AJ, Holleran JP, Avery VM, Healy PC, Davis RA. Design and Synthesis of a Screening Library Using the Natural Product Scaffold 3-Chloro-4-hydroxyphenylacetic Acid. J Nat Prod. 2015 Apr 24;78(4):914-8. doi: 10.1021/np500856u. Epub 2015 Mar 24. doi: 10.1111/j.1399-3054.2012.01715.x. Epub 2012 Nov 20. doi: 10.1093/jxb/erq172. Epub 2010 Jul 1.
4: Mani AR, Ippolito S, Moreno JC, Visser TJ, Moore KP. The metabolism and dechlorination of chlorotyrosine in vivo. J Biol Chem. 2007 Oct 5;282(40):29114-21. Epub 2007 Aug 8. Epub 2007 Jan 22. Epub 2006 Jun 27.
9: van de Pas BA, Jansen S, Dijkema C, Schraa G, de Vos WM, Stams AJ. Energy yield of respiration on chloroaromatic compounds in Desulfitobacterium dehalogenans. Appl Environ Microbiol. 2001 Sep;67(9):3958-63.
合成参考文献
摘要:Gekkan Yakuji. Pharmaceuticals Monthly., 17(2087), 1975
摘要:Drugs under Experimental and Clinical Research., 2(9), 1977
参考文献:10.1128/aem.67.9.3958-3963.2001
摘要:van de Pas BA, Jansen S, Dijkema C, Schraa G, de Vos WM, Stams AJM. Energy Yield of Respiration on Chloroaromatic Compounds in Desulfitobacterium dehalogenans. Appl Environ Microbiol. 2001 Sep;67(9):3958–63. doi: 10.1128/aem.67.9.3958-3963.2001.
参考文献:10.1111/j.1365-313x.2008.03495.x
摘要:Negi S, Ivanchenko MG, Muday GK. Ethylene regulates lateral root formation and auxin transport in Arabidopsis thaliana. The Plant Journal. 2008 Jul;55(2):175–87. doi: 10.1111/j.1365-313x.2008.03495.x.
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