CAS: 288148-34-5; 1-Methyl-1H-Pyrazole-4-Sulfonyl Chloride

相似化合物

957514-21-5 89501-93-9 1153041-98-5

上下游产品

CAS号930-36-9 1-甲基吡唑 | CAS号39806-90-1 1-甲基-4-碘-吡唑

1-甲基-4-碘-吡唑置于正丁基锂,二氧化硫,N-氯代丁二酰亚胺体系中,用 乙醚,二氯甲烷 用作溶剂,化学反应 5.0H,以100%的收率获得1-甲基-1H-吡唑-4-磺酰氯
参考文献:Discovery Of Heteroaryl Sulfonamides As New Ep1 Receptor Selective Antagonists
标题:Discovery Of Heteroaryl Sulfonamides As New Ep1 Receptor Selective Antagonists
摘要:4-({2-[isobutyl(Phenylsulfonyl)Amino]-5-(Trifluoromethyl)Phenoxy}Methyl)Benzoic Acid (1) Is A Functional Pge(2) Antagonist Selective For Ep1 Receptor Subtype. Analogs Of 1,In Which The Phenyl-Sulfonyl Moiety Has Been Replaced With More Hydrophilic Heteroarylsulfonyl Moieties,Exhibited More Optimized Antagonist Activity,While Some Of Them Showed In Vivo Antagonist Activity. Structure-Activity Relationship (Sar) Studies Are Also Presented. (C) 2006 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmc.2006.05.076

专利信息

专利号:US-8138272-B2
优先权日:2006-05-22
标 题:Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds
发明人：KONRADI ANDREI W; SMITH JENIFER L
权利人:KONRADI ANDREI W; SMITH JENIFER L; ELAN PHARM INC
摘要:This invention provides an improved synthesis of polymer conjugates of formula (I), n nof agricultural, therapeutic, and food additive compounds. In particular, a process is described for the preparation of conjugates by treating primary or secondary alcohol substituents of active compounds with polymeric nucleophiles using “Mitsunobuâ€? or related reaction conditions.

专利号:CN-117050075-A
优先权日:2022-05-05
标题:A class of biaromatic BET inhibitors and synthesis methods and uses