CAS: 20806-43-3; Z-Ser(Bzl)-Oh

相似化合物

10433-52-0 1145-80-8 23680-31-1

上下游产品

CAS号4726-96-9 O-苄基-L-丝氨酸 | CAS号31139-36-3 苄氧甲酸酐 | CAS号501-53-1 氯甲酸苄酯 | CAS号5445-44-3 O-苄基-DL-丝氨酸 | CAS号118867-04-2 Z-Ser(Bz)-OtBu | CAS号83824-86-6 benzylO-benzyl-... | CAS号75315-63-8 2,5-二氧代吡咯烷-1-羧酸苄酯 | CAS号22831-98-7 4-benzyloxymeth... | CAS号4726-96-9 O-苄基-L-丝氨酸 | CAS号56-45-1 L-丝氨酸 | CAS号98647-23-5 ZO-苄基-L-丝氨酸N-羟基...

📜(S)-Methyl 3-(Benzyloxy)-2-(Benzyloxycarbonylamino)Propanoate置于2C33H37N*h2O7S2,水体系中,化学反应 9.0H,以83%的收率获得cbz-O-苄基-L-丝氨酸
参考文献:N,N-焦硫酸二芳基铵作为高效逆胶束型酯水解催化剂
标题:N,N-焦硫酸二芳基铵作为高效逆胶束型酯水解催化剂
摘要:反胶束型n,N-焦硫酸二芳基铵(3-5摩尔%)在无有机溶剂的条件下有效催化酯的水解(最大100 Mmol规模).本方法成功地用于各种酯的水解,而没有碱敏感部分的分解,并且对于α-杂取代的羧酸没有任何光学纯度的损失.
Doi:10.1021/ol301290C

专利信息

专利号:US-5166212-A
优先权日:1985-12-06
标 题:Certain n-substituted butyramide derivatives
发明人：KSANDER GARY M
权利人:CIBA GEIGY CORP
摘要:Disclosed are compound of the formula (I) wherein X and Y independently represent hydroxymethyl; cyano; carboxy; functionally modified carboxy selected from esterified carboxy, carbamoyl, and N-substituted carbamoyl; 5-tetrazolyl; 2-oxazolyl, 4,5-dihydro-2-oxazolyl, or each said grouping substituted by lower alkyl; R and Ro independently represent lower alkyl, (C3-C7)-cycloalkyl-lower alkyl, or aryl-lower alkyl; A represents methylene; or A represents methylene substituted by lower alkyl, by lower alkylthio-lower alkyl, by aryl-lower alkylthio-lower alkyl, by arylthio-lower alkyl, by hydroxy-lower alkyl, by acyloxy-lower alkyl, by lower alkoxy-lower alkyl, by alkyloxy-lower alkyl, by aryloxy-lower alkyl, by amino-lower alkyl by acylamino-lower alkyl, by guanidino-lower amino-lower alkyl, by (C3-C7)-cycloalkyl, by (C3-C7)-cycloalkyl-lower alkyl, by aryl or aryl-lower alkyl; pharmaceutically acceptable ester and amide derivatives of any said compounds having a free carboxy group; pharmaceutically acceptable salts; methods for synthesis; pharmaceutical compositions thereof; and use thereof as endopentidase inhibitors.

专利号:US-5021430-A
优先权日:1985-12-06
标 题 :Certain N-substituted butyramide derivatives
发明人：KSANDER GARY M
权利人:CIBA GEIGY CORP
摘要:Disclosed are compound of the formula (I) wherein X and Y independently represent hydroxymethyl; cyano; carboxy; functionally modified carboxy selected from esterified carboxy, carbamoyl, and N-substituted carbamoyl; 5-tetrazolyl; 2-oxazolyl, 4,5-dihydro-2-oxazolyl, or each said grouping substituted by lower alkyl; R and Ro independently represent lower alkyl, (C3-C7)-cycloalkyl-lower alkyl, or aryl-lower alkyl; A represents methylene; or A represents methylene substituted by lower alkyl, by lower alkylthio-lower alkyl, by aryl-lower alkylthio-lower alkyl, by arylthio-lower alkyl, by hydroxy-lower alkyl, by acyloxy-lower alkyl, by lower alkoxy-lower alkyl, by aryl-lower alkyloxy-lower alkyl, by aryloxy-lower alkyl, by amino-lower alkyl, by acylamino-lower alkyl, by guanidino-lower alkyl, by (C3-C7)-cycloalkyl, by (C3-C7)-cycloalkyl-lower alkyl, by aryl or aryl-lower alkyl; pharmaceutically acceptable ester and amide derivatives of any said compounds having a free carboxy group; pharmaceutically acceptable salts; methods for synthesis; pharmaceutical compositions thereof; and use thereof as endopeptidase inhibitors.