CAS: 20469-89-0; 2-Bromo-2-Methylpropanoyl Chloride

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CAS号2052-01-9 2-溴代异丁酸 | CAS号79-30-1 异丁酰氯 | CAS号51368-55-9 2-溴代异丁酸异丙酯 | CAS号7462-74-0 2-溴异丁酰胺 | CAS号600-00-0 2-溴-2-甲基丙酸乙酯 | CAS号23426-63-3 2-溴异丁酸甲酯 | CAS号189324-13-8 2-溴-2-甲基丙酸2-羟乙酯 | CAS号69959-88-2 N-甲基2-溴异丁酰胺 | CAS号69959-91-7 N1-(1-异丙基-2-甲基丙... | CAS号66875-78-3 N-叔丁基-2-溴-2-甲基丙酰胺 | CAS号88876-29-3 2-bromo-N-ethyl... | CAS号60110-37-4 N-苄基-2-溴-2-甲基丙酰胺

2-溴-2-甲基丙酸置于氯化亚砜体系中,化学反应 6.0H,以100%的收率获得2-溴异丁酰氯
参考文献:开发基于艾乐替尼的 Protac 作为间变性淋巴瘤激酶 (Alk) 的新型强效降解剂
标题:开发基于艾乐替尼的 Protac 作为间变性淋巴瘤激酶 (Alk) 的新型强效降解剂
摘要:基于蛋白水解靶向嵌合体 (Protac) 技术,通过不同长度和类型的接头将两种艾乐替尼类似物(36和37)与泊马度胺连接起来,设计并合成了一系列新型间变性淋巴瘤激酶 (Alk) 降解剂.最有前途的降解剂17在 Alk 依赖性细胞系中具有高 Alk 结合亲和力和有效的抗增殖活性,并且在 Alk 融合阴性细胞中没有表现出明显的细胞毒性.更重要的是,化合物17在 Karpas 299 异种移植小鼠模型中的功效基于其 Alk 持续的体内降解能力进行了进一步评估.化合物17中肿瘤重量的减少治疗组(10 毫克/公斤/天,Iv)达到 75.82%,而艾乐替尼在 20 毫克/公斤/天(po)的剂量下使肿瘤重量减少了 63.82%.总之,我们的研究结果表明,与 Alk 降解相关的基于艾乐替尼的 Protacs 可能对治疗 Alk 驱动的恶性肿瘤具有非常好的疗效.
Doi:10.1021/acs.Jmedchem.1C00270

专利信息

专利号:US-2013165350-A1
优先权日:2011-12-22
标 题:Surface linkers for array synthesis
发明人：KUIMELIS ROBERT; MCGALL GLENN; PAO DEXTER; CHEN ZIHUI; AXELROD TREVOR
权利人:KUIMELIS ROBERT; MCGALL GLENN; PAO DEXTER; CHEN ZIHUI; AXELROD TREVOR; AFFYMETRIX INC
摘要:The present invention provide several methods of derivatizing a surface of a support with one or more linkers thus providing a suitable platform for synthesis of a polymer array, particular a nucleic acid array. Some methods derivatize a surface with a self-assembled monolayer (SAM) of a linker. The SAM confers advantages of hydrolytic stability, broad compatibility with synthesis and detection chemistries, and reduced emergence of latent functional groups during polymer array synthesis. Substrates can also be derivatized with multi-layers of SAMs providing greater hydrolytic stability. Substrates can also be derivatized by synthesizing a linker in situ on the substrate by atom transfer radical polymerization of functional and functional monomers. Appropriate selection of monomers reduces emergence of latent functional groups in subsequent array synthesis.

专利号:US-9551029-B2
优先权日:1999-06-03
标 题 :Methods and kits using extended rhodamine dyes
发明人：LAM JOE Y L; BENSON SCOTT C; MENCHEN STEVEN M
权利人:APPLIED BIOSYSTEMS LLC
摘要:Extended rhodamine compounds exhibiting favorable fluorescence characteristics having the structure n nare disclosed. In addition, novel intermediates for synthesis of these dyes are disclosed, such intermediates having the structuren n n n n n n n n n n In addition, methods of making and using the dyes as fluorescent labels are disclosed.