CAS: 1849-36-1; 4-Nitrothiophenol

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CAS号350-46-9 对氟硝基苯 | CAS号100-32-3 4,4'-二硝基二苯二硫醚 | CAS号636-98-6 4-硝基碘苯 | CAS号243671-59-2 1-methyl-4-[[(Z... | CAS号3270-86-8 O,O-二乙基-S-(对硝基苯... | CAS号100-00-5 对硝基氯苯 | CAS号123-75-1 四氢吡咯 | CAS号1401246-35-2 trans-[(dipheny... | CAS号39565-05-4 5-(4-硝基苯磺酰)噻唑-2-胺 | CAS号350-46-9 对氟硝基苯 | CAS号3406-75-5 2-[(4-硝基苯基)磺酰基]乙酸 | CAS号147591-62-6 2-[2-(4-aminoph... | CAS号403-66-7 4-三氟甲硫基硝基苯 | CAS号19821-06-8 diethoxy-(4-nit... | CAS号18527-26-9 2-(4-nitropheny... | CAS号19117-41-0 2-methyl-N-(4-n... | CAS号22873-15-0 Methylcarbamoth... | CAS号21298-67-9 2,2-bis[(4-nitr...

(R)-N-(3-Benzoyl-2-((P-Nitrophenyl)Thio)Propanoyl)-L-Phenylalanine置于angiotensin Converting Enzyme Potassium Chloride,Zinc(II) Chloride体系中,用 1,4-二氧六环 用作溶剂,化学反应生成4-硝基苯硫醇
参考文献:Catalytic Versatility Of Angiotensin Converting Enzyme: Catalysis Of An .Alpha.,.Beta.-Elimination Reaction
标题:Catalytic Versatility Of Angiotensin Converting Enzyme: Catalysis Of An .Alpha.,.Beta.-Elimination Reaction
摘要:
Doi:10.1021/ja00333A067

专利信息

专利号:US-10150160-B2
优先权日:2014-12-04
标题 :Universal one-pot and up-scalable synthesis of SERS encoded nanoparticles
发明人：PAZOS PÉREZ NICOLÃ?S; MIR DE SIMÓN BERNAT
权利人:MEDCOM ADVANCE S A; MEDCOM ADVANCE S A
摘要:The universal one-pot and up-scalable synthesis of SERS encoded nanoparticles relies on the controlled co-absorption of mercaptoundecanoic acid (MUA) and the Raman code on the metallic surfaces of the nanoparticles. In contrast to most of the reported procedures which typically involve complex steps, the present method has demonstrated to be an easy and fast one-pot approach for the production of SERS-encoded nanoparticles. This versatile strategy allows for the SERS codification of particles with every molecule with affinity toward the metal surface, independently of its chemical nature, as exemplified here in the fabrication of 31 different encoded particles using the same standard procedure. In addition to the easiness of preparation, scalability to the liter regime, stability in aqueous solutions including PBS and chemical diversity, our SERS-encoded particles show considerably higher optical efficiency than those fabricated by using PEG or PVP polymers.

专利号:US-10961273-B2
优先权日:2016-08-16
标 题 :N-carboxyanhydride-based-scale synthesis of elamipretide
发明人：DUNCAN SCOTT M; OUDENES JAN; ANDERSEN MARC W
权利人:STEALTH BIOTHERAPEUTICS CORP
摘要:Disclosed are methods of making elamipretide (MTP-131), a peptide compound with therapeutic potential for treating various mitochondrial myopathies. The synthesis of the peptide can be achieved via the use of N-carboxyanhydride-modified amino acid residues, which increases the efficiency of the synthetic process and the purity of the peptide product generated.

专利号:US-2008221303-A1
优先权日:2004-02-18
标 题:Method for the Preparation of Peptide-Oligonucleotide Conjugates
发明人：KATZHENDLER JEHOSHUA; KLAUZNER YAKIR; BEYLIS IRENA; MIZHIRITSKII MICHAEL; SHPERNAT YAACOV; ASHKENAZI BORIS; FRIDLAND DMITRI
权利人:KATZHENDLER JEHOSHUA; KLAUZNER YAKIR; BEYLIS IRENA; MIZHIRITSKII MICHAEL; SHPERNAT YAACOV; ASHKENAZI BORIS; FRIDLAND DMITRI
摘要:The present invention relates to the synthesis of peptide-oligonucleotide conjugates (POC). More specifically, the invention relates to a novel method for the preparation of peptide-oligonucleotide conjugates, which can be conducted under mild conditions on solid support, can be performed manually or by a synthesizer, can be used to synthesize alternating sequences of peptides and oligonucleotides, and is applicable to the synthesis of a wide variety of peptide-oligonucleotide conjugates constructed from alternate peptide and oligonucleotide blocks.

专利号:US-9815809-B2
优先权日:2013-07-05
标题:Formation of chiral 4-chromanones using chiral pyrrolidines in the presence of phenols or thiophenols
发明人：LETINOIS ULLA; NETSCHER THOMAS
权利人:DSM IP ASSETS BV
摘要:The present invention relates to a synthesis of chromanones or chromanes in a stereospecific matter in view of the 2-position in the chromanone or chromane ring. It has been found that this synthesis is particularly possible in the presence of a chiral compound of formula of a specific type and of at least one phenol or thiophenol.

专利号:US-7674881-B2
优先权日:2005-10-07
标题:Convergent synthesis of proteins by kinetically controlled ligation
发明人：KENT STEPHEN; PENTELUTE BRAD; BANG DUHEE; JOHNSON ERIK; DUREK THOMAS
权利人:UNIV CHICAGO
摘要:The present invention concerns methods and compositions for synthesizing a polypeptide using kinetically controlled reactions involving fragments of the polypeptide for a fully convergent process. In more specific embodiments, a ligation involves reacting a first peptide having a protected cysteyl group at its N-terminal and a phenylthioester at its C-terminal with a second peptide having a cysteine residue at its N-termini and a thioester at its C-termini to form a ligation product. Subsequent reactions may involve deprotecting the cysteyl group of the resulting ligation product and/or converting the thioester into a thiophenylester.

专利号:US-6015895-A
优先权日:1995-12-22
标 题 :Linker arm for solid support oligonucleotide synthesis and process for production thereof
发明人：PON RICHARD T; YU SHUYUAN
权利人:UNIV TECHNOLOGIES INT
摘要:PCT No. PCT/CA96/00837 Sec. 371 Date Jun. 19, 1998 Sec. 102(e) Date Jun. 19, 1998 PCT Filed Dec. 13, 1996 PCT Pub. No. WO97/23497 PCT Pub. Date Jul. 3, 1997A linker arm for solid support oligonucleotide synthesis, the linker arm comprising formula (1), wherein: X1 is selected from the group consisting of -O-, -S-, -S(O)2-, -C(O)- and -N(R12)-; R12 is selected from the group comprising hydrogen, a substituted or unsubstituted C1-C20 alkyl group, a substituted or unsubstituted C5-C30 aryl group and a substituted or unsubstituted C5-C40 alkaryl group, X3 is -O- or -N(H)-; R1, R2, R3, R4 and R5 are the same or different and are selected from the group consisting of hydrogen, halide, a substituted or unsubstituted C1-C20 alkyl group, a substituted or unsubstituted C5-C30 aryl group and a substituted or unsubstituted C5-C40 alkylaryl group; n is 0, 1 or 2; and one of A' and B' is selected from the group consisting of hydrogen, halide, a substituted or unsubstituted C1-C20 alkyl group, a substituted or unsubstituted C5-C30 aryl group and a substituted or unsubstituted C5-C40 alkylaryl group, and the other of A' and B' has formula (2), wherein X2 is selected from the group consisting of -O-, -S-, -S(O)2- and -N(R13)-; R13 is selected from the group comprising hydrogen, a substituted or unsubstituted C1-C20 alkyl group, a substituted or unsubstituted C5-C30 aryl group and a substituted or unsubstituted C5-C40 alkaryl group; R6 and R7 are the same or different and are selected from the group consisting of hydrogen, halide, a substituted or unsubstituted C1-C20 alkyl group, a substituted or unsubstituted C5-C30 aryl group and a substituted or unsubstituted C5-C40 alkylaryl group; p is 0 or 1; and m is 0, 1 or 2. A process for producing the linker arm is also disclosed. The linker arm is useful in solid support oligonucleotide synthesis and is characterized by a desirable combination of stability against spontaneous hydrolysis and ease of intentional cleavage of the synthesized oligonucleotide from the linker arm.