CAS: 16629-19-9; Thiophene-2-Sulfonyl Chloride

相似化合物

2766-74-7 185329-76-4 55854-46-1

上下游产品

thiophene 2-Iodothiophene tributyl(thien-2-yl)stannane 2-thiophenesulfonic acid N-phenyl-S-2-thiophenylsulfonamide 2-(benzenesulfonyl)thiophene 2-thiophensulfonamide 2-thienyl disulfide

噻吩置于氯磺酸,五氯化磷体系中,化学反应 5.0H,以74%的收率获得2-噻吩磺酰氯
参考文献:一些沙利度胺代谢物作为针对多发性骨髓瘤的选择性细胞毒性和抗血管生成剂的基于类似物的设计,合成,生物学评估和分子对接
标题:一些沙利度胺代谢物作为针对多发性骨髓瘤的选择性细胞毒性和抗血管生成剂的基于类似物的设计,合成,生物学评估和分子对接
摘要:摘要 本文描述了沙利度胺代谢物的一些生物等排体对多发性骨髓瘤的抗血管生成和抗癌活性的合成和评价.四种化合物,2-(噻吩-2-磺酰胺)戊二酸二乙酯,N 1,N 5-二乙基-2-(噻吩-2-磺酰胺)戊二酰胺,N 1,N 5-二己基-2-(噻吩-2-磺酰胺) ) 戊二酰胺和n-(1,5-Dioxo-1,5-Bis(2-Phenylhydrazinyl)Pentan-2-yl)Thiophene-2-Sulfonamide 对人多发性骨髓瘤细胞系 (Rpmi8226) 具有细胞毒性作用,Ic 50(以 μm 为单位)值分别为 3.33,0.75,1.23 和 3.28.对人脐静脉内皮细胞 (Huvec) 和正常非洲绿猴肾上皮细胞 (Vero 细胞系) 的体外研究得出结论,这些化合物具有抗血管生成特性,并且对癌细胞具有选择性细胞毒性.除n-(1,5-Dioxo-1,5-Bis(2-Pheny
Doi:10.1134/s1068162022010022

专利信息

专利号:US-12139504-B2
优先权日:2022-08-09
标 题:Vanadium alkylidene complex, synthesis and use thereof
发明人：BUKHRYAKOV KONSTANTIN; BELOV DMITRY
权利人:BUKHRYAKOV KONSTANTIN; BELOV DMITRY; THE FLORIDA INTERNATIONAL UNIV BOARD OF TRUSTEES
摘要:The subject invention provides catalytical compounds/complexes, compositions comprising such compound/complex, synthesis of the compounds/complexes, and methods of using such compounds/complexes as catalysts in, for example, RCM reactions. Specifically, the subject invention provides the synthesis of the first catalytically active V oxo alkylidene, VO(CHSiMe 3 )(PEt 3 ) 2 Cl, which exhibits superior performance compared to other analogs.

专利号:US-11897827-B1
优先权日:2022-11-22
标 题 :Carbon isotope exchange mediated by vanadium complexes
发明人：BUKHRYAKOV KONSTANTIN
权利人:BUKHRYAKOV KONSTANTIN; THE FLORIDA INTERNATIONAL UNIV BOARD OF TRUSTEES
摘要:The subject invention provides catalytical compounds/complexes, compositions comprising such compound/complex, synthesis of the compounds/complexes, and methods of using such compounds/complexes as catalysts in, for example, carbon isotope exchange (CIE) on target bioactive molecules. Methods that allow CIE directly on drug candidates are of great importance to chemistry, biology, and medicine. Especially valuable are catalytic procedures that rely on a limited collection of available labeled materials. The instant method comprises converting a methyl group to terminal â•?CH2 utilizing transfer dehydrogenation catalysts to enable V-based olefin metathesis, followed by a hydrogenation step. The one-pot strategy allows the formal methylation/demethylation sequence and can be applied to an assortment of alkyl-containing compounds.

专利号:US-9574189-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries
发明人：FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK
权利人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK; NUEVOLUTION AS
摘要:Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).

专利号:US-8138272-B2
优先权日:2006-05-22
标 题:Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds
发明人：KONRADI ANDREI W; SMITH JENIFER L
权利人:KONRADI ANDREI W; SMITH JENIFER L; ELAN PHARM INC
摘要:This invention provides an improved synthesis of polymer conjugates of formula (I), n nof agricultural, therapeutic, and food additive compounds. In particular, a process is described for the preparation of conjugates by treating primary or secondary alcohol substituents of active compounds with polymeric nucleophiles using “Mitsunobuâ€? or related reaction conditions.

专利号:US-6872716-B2
优先权日:2000-09-11
标题:Antipsychotic sulfonamide-heterocycles, and methods of use thereof
发明人：WU XINHE; AQUILA BRIAN M; SHAO LIMING; RADEKE HEIKE; CUNY GREGORY D; HAUSKE JAMES R; XIE ROGER L
权利人:SEPRACOR INC
摘要:One aspect of the present invention relates to heterocyclic compounds comprising a sulfonamide moiety. A second aspect of the present invention relates to the use of the heterocyclic compounds comprising a sulfonamide moiety to treat diseases, afflictions or maladies caused at least in part by abnormal activity of one or more GPCRs or ligand-gated ion channels. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the heterocyclic compounds comprising a sulfonamide moiety, and the screening of those libraries for biological activity, e.g., in animal models of psychosis.

专利号:US-7074921-B2
优先权日:2001-11-13
标题 :Process for the preparation of 3,7-disubstituted-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine compounds
发明人：KRONENTHAL DAVID R; BHANDARU RAO S; SHI ZHONGPING; MUDRYK BOGUSLAW M
权利人:BRISTOL MYERS SQUIBB CO
摘要:Methods for the synthesis of benzodiazepine compounds having farnesyl protein transferase inhibitory activity.