CAS: 1618-36-6; 4-Chloro-5-Methyl-7H-Pyrrolo[2,3-D]Pyrimidine

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CAS号22276-95-5 5-溴-4-氯-7H-吡咯并[... | CAS号74-88-4 碘甲烷 | CAS号3680-69-1 6-氯-7-氮杂嘌呤 | CAS号115093-90-8 4,5-二氯-7H-吡咯并[2...

4-氯吡咯并嘧啶置于n-溴代丁二酰亚胺(Nbs),正丁基锂体系中,用 四氢呋喃,二氯甲烷 用作溶剂,化学反应生成4-氯-5-甲基-7H-吡咯并[2,3-D]嘧啶
参考文献:某些5位取代2'-脱氧结核精衍生物的合成
标题:某些5位取代2'-脱氧结核精衍生物的合成
摘要:描述了在c(5)处带有氯,溴或甲基取代基的7-Deaza-2'-Deoxy-腺嘌呤衍生物7B-3的合成.5-取代的4-氯吡咯并[2,3-D ]嘧啶4B-D与2-脱氧-3,5-二-O-(4-甲苯甲酰基)-α-D-赤型-戊呋喃糖酰氯的糖基化作用(3)仅给出了β-D-核苷5B-d.将它们解封(6B-d)并转化为结核菌素衍生物7B-d.
Doi:10.1002/hlca.19940770403

专利信息

专利号:US-8853373-B2
优先权日:2009-08-14
标题 :Method and reagent for gene sequence analysis
发明人：KUWAHARA MASAYASU; KAJIYAMA TOMOHARU; KAMBARA HIDEKI
权利人:KUWAHARA MASAYASU; KAJIYAMA TOMOHARU; KAMBARA HIDEKI; HITACHI LTD; UNIV GUNMA NAT UNIV CORP
摘要:Provided is a nucleic acid substrate which has nucleic acid substrate characteristics equivalent to those of dATP, has a low substrate specificity for luciferase, exerts no negative effect on enzymatic reactions such as a complementary-strand synthesis, and therefore is particularly suitable for the pyrosequencing method. As a nucleic acid substrate complementary to nucleotide T, a 7-substituted deoxyribonucleotide triphosphate whose 7-position of a purine group is modified by a substituent is used as a substitute for a nucleotide α-thiotriphosphate analog.

专利号:WO-2007047793-A2
优先权日:2005-10-19
标 题 :Cyclopentenol nucleoside compounds, intermediates for their synthesis and methods of treating viral infections