CAS: 147201-04-5; (2R,3R,4R,5R)-2-((Bis(4-Methoxyphenyl)(Phenyl)Methoxy)Methyl)-4-((Tert-Butyldimethylsilyl)Oxy)-5-(2-Isobutyramido-6-Oxo-1,6-Dihydro-9H-Purin-9-yl)Tetrahydrofuran-3-Yl (2-Cyanoethyl) Diisopropylphosphoramidite

该化合物是核酸合成领域常用的,特别是用于核酸聚变的核酸化聚物的磷米底酸衍生物,特别是固相聚聚聚物,该化合物具有若干关键功能组,包括位于5号位置的角氧基三丁基保护组,这有助于在合成过程中有选择地将核糖化物结合在一起;2号位置上存在一种异丁基二甲基硅酸组,为避免不必要的反应提供了额外的保护,加强了核糖分在合成过程期间的稳定性;异丁烯组有助于分子的整体稳定性和再活性,而丙烯酸乙基磷酰胺对形成核酸结合中的磷酰联结至关重要;总体而言,该复合体的特点是结构复杂,有利于实验室环境中对核酸序列进行有效和控制的组合.

英文名称(2R,3R,4R,5R)-2-((Bis(4-Methoxyphenyl)(Phenyl)Methoxy)Methyl)-4-((Tert-Butyldimethylsilyl)Oxy)-5-(2-Isobutyramido-6-Oxo-1,6-Dihydro-9H-Purin-9-yl)Tetrahydrofuran-3-Yl (2-Cyanoethyl) Diisopropylphosphoramidite
中文名称5'-O-(4,4-二甲氧基三苯甲基)-2'-O-[(叔丁基)二甲基硅基]-N-异丁酰基鸟苷-3'-(2-氰基乙基-N,N-二异丙基)亚磷酰胺
IUPAC名称(2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
其它别名5'-O-[bis(4-Methoxyphenyl)(Phenyl)Methyl]-2'-O-[tert-Butyl(Dimethyl)Silyl]-3'-O-{(2-Cyanoethoxy)[di(Propan-2-yl)Amino]Phosphanyl}-N-(2-Methylpropanoyl)Guanosine; 5'-O-(4,4'-Dimethoxy)-N2-Isobutyryl-Guanosine 2'-O-[1,1-Dimethylethyl)Dimethylsilyl-3'-[(2-C
CAS编号147201-04-5
MFCD编号:MFCD00080299
分子式:C50H68N7O9PSi
分子量:970.18
产品CID: 703278
产品分类有机原料→生命科学→核苷&核苷酸→卤素修饰性核苷

相似结构搜索
InChIKey: PGJKESPHANLWME-FTZVBZPOSA-N
PGJKESPHANLWME-FTZVBZPOSA-N…
计算化学: 氢键受体数14.0氢键供体数2.0可旋转键数21.0

相似化合物

1445905-51-0 150780-67-9 149559-87-5

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
UN编号NONH for all modes of transport
危险品标志Xi
安全声明H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
WGK Germany3

上下游产品

CAS号102691-36-1 双(二异丙基氨基)(2-氰基乙氧基)膦 | CAS号81279-39-2 5'-O-[双(4-甲氧基苯基... | CAS号108-18-9 二异丙胺

合成工艺路线路线简述

专利信息

专利号:US-2005059817-A1
优先权日:2000-09-01
标题 :Methods for synthesizing nucleosides, nucleoside derivatives and non-nucleoside derivatives
发明人：BEIGELMAN LEONID; KARPEISKY ALEXANDER; SEREBRYANY VLADMIR; HAEBERLI PETER; SWEEDLER DAVID
权利人:SIRNA THERAPEUTICS INC
摘要:The present invention provides methods for the chemical synthesis of nucleosides and derivatives thereof, including 2â€²-amino, 2â€²-N-phthaloyl, 2â€²-O-methyl, 2â€²-0-silyl, 2â€²-O-triisopropylsilyloxymethyl, 2â€²-OH nucleosides, C-nucleosides, nucleoside phosphoramidites, C-nucleoside phosphoramidites, and non-nucleoside derivatives.

专利号:US-6686463-B2
优先权日:2000-09-01
标题 :Methods for synthesizing nucleosides, nucleoside derivatives and non-nucleoside derivatives
发明人：BEIGELMAN LEONID; KARPEISKY ALEXANDER; SEREBRYANY VLADMIR; HAEBERLI PETER; SWEEDLER DAVID
权利人:SIRNA THERAPEUTICS INC
摘要:The present invention provides methods for the chemical synthesis of nucleosides and derivatives thereof, including 2'-amino, 2'-N-phthaloyl, 2'-O-methyl, 2'-O-silyl, 2'-OH nucleosides, C-nucleosides, nucleoside phosphoramidites, C-nucleoside phosphoramidites, and non-nucleoside derivatives.