CAS: 107-73-3; N,N,N-Trimethyl-2-(Phosphonooxy)Ethanaminium Chloride

相似化合物

72556-74-2 4826-71-5 16904-96-4

上下游产品

choline chloride 2-chloroethyl phosphorodichloridate phosphorylcholine chloride, calcium salt N,N-dimethylbutylaminecholine chloride citicoline L-glycero-3-phosphorylcholine glycerolcholine phosphate

氯化胆碱置于ppa体系中,150.0 °C,6.67 Kpa 条件下,反应生成磷酸胆碱
参考文献:进行酯化和酯转化研究xvi酰胺化胆碱磷酸酯†
标题:进行酯化和酯转化研究xvi酰胺化胆碱磷酸酯†
摘要:将1摩尔胆碱或氯化胆碱与0.5至0.6摩尔焦磷酸(或相应量的多磷酸)在减压下于150oc加热20小时,即可获得高产率的磷酸胆碱.
Doi:10.1002/hlca.19590420405

专利信息

专利号:US-9643915-B2
优先权日:2013-03-15
标题:Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
发明人：ONICIU DANIELA CARMEN; HECKHOFF STEFAN; OSWALD BENOIT; REBMANN PETER; PEER ANDREAS; GONZALEZ MIGUEL; SAUTER PATRIK
权利人:CERENIS THERAPEUTICS HOLDING SA
摘要:The present invention includes methods for the synthesis of sphingomyelins and dihydrosphingomyelins. The present invention also includes methods for the synthesis of sphingosines and dihydrosphingosines. The present invention further includes methods for the synthesis of ceramides and dihydroceramides.

专利号:US-9708354-B2
优先权日:2013-03-15
标 题:Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
发明人：ONICIU DANIELA CARMEN; HECKHOFF STEFAN; OSWALD BENOIT; REBMANN PETER; PEER ANDREAS; GONZALEZ MIGUEL; SAUTER PATRIK
权利人:CERENIS THERAPEUTICS HOLDING SA
摘要:The present invention includes methods for the synthesis of sphingomyelins and dihydrosphingomyelins. The present invention also includes methods for the synthesis of sphingosines and dihydrosphingosines. The present invention further includes methods for the synthesis of ceramides and dihydroceramides.

专利号:US-11414687-B2
优先权日:2017-10-04
标题:Method and system for enzymatic synthesis of oligonucleotides
发明人：HOFF KENDALL; HALPAIN MICHELLE; GARBAGNATI GIANCARLO; ZHOU WEI
权利人:CENTRILLION TECH HOLDINGS CORP
摘要:The present disclosure relates to methods, processes and systems for enzymatic synthesis of oligonucleotide from a single-stranded, immobilized primer in the presence of a polymerase. Using the disclosed methods single-stranded oligonucleotides can be synthesized enzymatically from a single-stranded, immobilized primer in the presence of deoxyribonucleotide triphosphates or ribonucleotide triphosphates. Dideoxyribonucleotide triphosphates, deoxyribonucleotide triphosphates with reversible terminators, or ribonucleotide triphosphates with reversible terminators can be added enzymatically to the end of the primer or its extension products. According to the disclosed method, a single-stranded primer can bind to a template such that the thus-formed double-stranded structure can allow the polymerase to extend the primer at 3′ end.

专利号:WO-9714703-A1
优先权日:1995-10-16
标 题:Synthesis of polymerisable phosphodiesters
发明人：DRIVER MICHAEL JOHN; RUSSEL JEREMY COLIN; BROWNE JUDITH ELIZABETH; SAMMES PETER G
权利人:BIOCOMPATIBLES LTD; DRIVER MICHAEL JOHN; RUSSEL JEREMY COLIN; BROWNE JUDITH ELIZABETH; SAMMES PETER G
摘要:A mono- or di-functional phosphoramidite phosphitylating agent is used to phosphitylate an ethylenically unsaturated alcohol. The product may be oxidised to form the corresponding phosphate ester which may be reacted in further steps to form phosphoryl choline derivatives. The process is of value in the synthesis of 2-(Methacryloyloxyethyl)-2'-(trimethylammoniumethyl)phosphate, inner salt. It has the advantage over prior art processes in that the starting materials and intermediates are more stable and consequently easier to handle.

专利号:US-5220043-A
优先权日:1991-03-21
标 题:Synthesis of D-erythro-sphingomyelins
发明人：DONG ZHENGXIN; BUTCHER JR JARED A
权利人:UNIV OHIO
摘要:A method for making optically pure D-erythro-sphingomyelins which may be labeled for identification and testing purposes is provided. The present method is directed to a five step synthesis comprising the steps of: (1) reacting a (2S,3R,4E)-2-azido-octadecen-1,3-diol composition having a protective functional group attached thereto with a solution of triphenylphosphine and water in a first solvent to form a protected sphingosine; (2) reacting a long-chain fatty acid with the protected sphingosine in the presence of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline catalyst in a second solvent to form a protected ceramide; (3) reacting 2-chloro-2-oxo-1,3,2-dioxaphospholane with the protected ceramide in the presence of triethylamine and 4-dimethylaminopyridine catalyst in a third solvent to form a protected cyclic phosphotriester; (4) reacting trimethylamine with the protected cyclic phosphotriester in a solvent system to form a protected sphingomyelin; and (5) reacting tetra-n-butylammonium fluoride with the protected sphingomyelin in tetrahydrofuran to form the D-erythro-sphingomyelin composition.

专利号:US-11766432-B2
优先权日:2018-07-27
标题 :Cleavable conjugates of catechol compounds and water-soluble polymers and methods of treatment using the same
发明人：BENTLEY MICHAEL; FANG ZHIHAO; WEIMER REBECCA; VIEGAS TACEY; MOREADITH RANDALL
权利人:SERINA THERAPEUTICS INC
摘要:Described are conjugates comprising a water-soluble polymer linked to a compound comprising a catechol moiety via a cleavable linkage, wherein the cleavable linkage is formed between the water-soluble polymer and a first phenolic hydroxyl group of the catechol moiety and a second phenolic hydroxyl group of the catechol moiety is linked to a blocking group wherein the rate of hydrolytic release of the compound comprising the catechol moiety is controlled, at least in part, through structure or design of the blocking group on the second phenolic hydroxyl group of the catechol moiety. Therefore, the rate of hydrolytic release of the compound comprising the catechol moiety can be tuned through structural design of the group on the second phenolic hydroxyl group of the catechol moiety. Compounds used in the synthesis of the described conjugates and methods of using the described conjugate and other compounds in the treatment of dopamine-responsive disorders are also described.