CAS: 87694-52-8; (S)-Tert-Butyl (1-(Methoxy(Methyl)Amino)-3-Methyl-1-Oxobutan-2-yl)Carbamate

该化合物其结构特征为叔丁基碳基(Boc)保护组,通常用于浸泡合成以保护氨基酸的氨基组,该组含有L-valine脊椎,这是氨基酸的基本成分之一,并配有甲基氧和氮原子上的甲基组,以提高其溶解性和稳定性,该组通常用于有机合成和丙酸化学,特别是制药和生物活性化合物的开发,其结构特征有助于其各种化学反应中的再活性和功能,使其成为合成途径中有价值的中间体.与许多化学物质一样,应观察与使用该物质相关的潜在危害有关的适当处理和安全防范.

结构式图片

相似化合物

106391-88-2 87694-49-3 146553-06-2

物理性质

MSDS等安全信息

上下游产品

CAS号13734-41-3 B°C-L-缬氨酸 | CAS号6638-79-5 二甲羟胺盐酸盐 | CAS号1117-97-1 甲氧基甲基胺 | CAS号133010-02-3 Carbamic acid, ... | CAS号54430-66-9 8-acetyl-7-hydr... | CAS号143327-78-0 Carbamic acid, ... | CAS号79069-51-5 (S)-(3-甲基-1-氧代丁...

合成工艺路线路线简述

  • 6638-79-5 + 13734-41-3 = 87694-52-8
    反应条件:1.1 Reagents: 4-Methylmorpholine,1-Hydroxybenzotriazole,1-Ethyl-3-(3′-Dimethylaminopropyl)Carbodiimide Hydrochloride Solvents: Dichloromethane; 35 Min,-3 °C; -3 °C -> Rt; 19 H,Rt; 40 Min,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water
    标题:Design,Synthesis,And Biological Activity Of Isosyringolin A
    作者:Kitahata,Shun; Et Al
    参考文献:Organic Letters 日期:2016 卷标:18(9) 页码:2312-2315]

    1117-97-1 + 13734-41-3 = 87694-52-8
    反应条件:1.1 Reagents: Diisopropylethylamine,Deoxo-Fluor Solvents: Dichloromethane; 0.25 - 0.5 H,0 °C1.2 Solvents: Dichloromethane; 0.25 H,0 °C; 0 °C -> Rt; 6 H,Rt
    标题:[bis(2-Methoxyethyl)Amino]Sulfur Trifluoride,The Deoxo-Fluor Reagent: Application Toward One-Flask Transformations Of Carboxylic Acids To Amides
    作者:White,Jonathan M.; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2004 卷标:69(7) 页码:2573-2576]

    24424-99-5 + 72-18-4 + 6638-79-5 = 87694-52-8
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: 1,4-Dioxane,Water; 30 Min,0 °C; 0 °C -> Rt; Overnight,Rt1.2 Reagents: Hydrochloric Acid Solvents: Ethyl Acetate,Water; Ph 2 - 3,Cooled1.3 Reagents: 4-Methylmorpholine,1-Ethyl-3-(3′-Dimethylaminopropyl)Carbodiimide Hydrochloride Solvents: Dichloromethane; 15 Min,-15 °C; 2 H,Rt1.4 Reagents: Hydrochloric Acid Solvents: Water; Cooled
    标题:Total Synthesis Of Syringolin A
    作者:Dai,Chunhui; Et Al
    参考文献:Organic Letters 日期:2010 卷标:12(15) 页码:3453-3455]

    13734-41-3 = 87694-52-8 [标题:Reaction Conditions
    标题:A Facile Approach To Trans-4,5-Pyrrolidine Lactam And Application In The Synthesis Of Nemonapride And Streptopyrrolidine
    作者:Huang,Wei; Et Al
    参考文献:Tetrahedron 日期:2011 卷标:67(40) 页码:7829-7837]

    6638-79-5 + 13734-41-3 = 87694-52-8
    反应条件:1.1 Reagents: 1,1′-Carbonyldiimidazole Solvents: Dichloromethane; Rt; 1.25 H,Rt1.2 Solvents: Dichloromethane; Overnight,Rt
    标题:Heterocyclic Cathinones As Inhibitors Of Kynurenine Aminotransferase Ii-Design,Synthesis,And Evaluation
    作者:Maryska,Michal; Et Al
    参考文献:Pharmaceuticals 日期:2021 卷标:14(12)]

    6638-79-5 + 13734-41-3 = 87694-52-8
    反应条件:1.1 Reagents: Diisopropylethylamine,Bop Reagent Solvents: Dichloromethane; Overnight,Rt
    标题:Radiolabeled Antagonistic Bombesin Peptidomimetics For Tumor Targeting
    作者:Valverde,Ibai E.; Et Al
    参考文献:Journal Of Labelled Compounds And Radiopharmaceuticals 日期:2014 卷标:57(4) 页码:275-278]

    1117-97-1 + 13734-41-3 = 87694-52-8
    反应条件:1.1 Reagents: Diisopropylethylamine,O-(Benzotriazol-1-Yl)-N,N,N′,N′-Tetramethyluronium Tetrafluoroborate Solvents: Dichloromethane; Rt
    标题:α-Aminoxy Acids As Building Blocks For The Oxime And Hydroxylamine Pseudopeptide Links. Application To The Synthesis Of Human Elastase Inhibitors
    作者:Vanderesse,Regis; Et Al
    参考文献:Journal Of Peptide Science 日期:2003 卷标:9(5) 页码:282-299]

    1117-97-1 + 13734-41-3 = 87694-52-8
    反应条件:1.1 Reagents: Diisopropylethylamine,Pybop Solvents: Dimethylformamide; 0.5 H,Rt1.2 Reagents: Diisopropylethylamine Solvents: Dimethylformamide; Overnight,Rt
    标题:Enzymatic Macrocyclization Of 1,2,3-Triazole Peptide Mimetics
    作者:Oueis,Emilia; Et Al
    参考文献:Angewandte Chemie 日期:2016 卷标:55(19) 页码:5842-5845]

    24424-99-5 + 72-18-4 + 6638-79-5 = 87694-52-8
    反应条件:1.1 Reagents: Triethylamine Solvents: Methanol; 16 H,Rt1.2 Reagents: Triethylamine,1-Hydroxybenzotriazole,1-Ethyl-3-(3′-Dimethylaminopropyl)Carbodiimide Hydrochloride Solvents: Dichloromethane; 10 Min,Rt1.3 16 H,Rt
    标题:Convenient Synthesis Of Alternatively Bridged Tryptophan Ketopiperazines And Their Activities Against Trypanosomatid Parasites
    作者:Cockram,Peter E.; Et Al
    参考文献:Chemmedchem 日期:2022 卷标:17(4)]

    6638-79-5 = 87694-52-8
    反应条件:1.1 Solvents: Tetrahydrofuran; 5 Min; 24 H,Rt
    标题:An Efficient Conversion Of Carboxylic Acids Into Weinreb Amides
    作者:Katritzky,Alan R.; Et Al
    参考文献:Arkivoc (Gainesville 日期:2002 卷标:(11) 页码:39-44]

    37073-15-7 + 13734-41-3 = 87694-52-8
    反应条件:1.1 Reagents: Triethylamine Solvents: Tetrahydrofuran; Rt; 6 - 12 H,Reflux2.1 Solvents: Tetrahydrofuran; 5 Min; 24 H,Rt
    标题:An Efficient Conversion Of Carboxylic Acids Into Weinreb Amides
    作者:Katritzky,Alan R.; Et Al
    参考文献:Arkivoc (Gainesville 日期:2002 卷标:(11) 页码:39-44]

    24424-99-5 + 72-18-4 = 87694-52-8
    反应条件:1.1 Reagents: Triethylamine Solvents: Methanol; 16 H,Rt2.1 Reagents: Triethylamine,1-Hydroxybenzotriazole,1-Ethyl-3-(3′-Dimethylaminopropyl)Carbodiimide Hydrochloride Solvents: Dichloromethane; 10 Min,Rt2.2 16 H,Rt
    标题:Convenient Synthesis Of Alternatively Bridged Tryptophan Ketopiperazines And Their Activities Against Trypanosomatid Parasites
    作者:Cockram,Peter E.; Et Al
    参考文献:Chemmedchem 日期:2022 卷标:17(4)
📜N-Boc-L-缬氨酸 反应生成 N-(叔丁氧基羰基)-L-缬氨酸n-甲氧基-N-甲基酰胺
参考文献:Crcl 2介导n保护的α-氨基醛的烯丙基化.包含羟乙烯等排异构体的多肽的多功能合成
标题:Crcl 2介导n保护的α-氨基醛的烯丙基化.包含羟乙烯等排异构体的多肽的多功能合成
摘要:不同取代的烯丙基溴与n-保护的氨基醛反应,反应生成用于合成羟乙烯二肽等排体的中间产物.使用受阻基团保护的醛可以改善该反应的低立体选择性.该反应可以有效地应用于寡肽醛.我们描述了一种用于制备含有羟乙烯等排体的肽的方案,该方案可以快速改变氨基酸序列
DOI:10.1016/s0040-4039(00)76862-6

海关参考信息

专利信息


专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

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主要参考文献

参考标题:Synthesis Of New Chiral Peptide Nucleic Acid (Pna) Monomers
作者:Bogdan Falkiewicz,Wojciech Wiśniowski,Aleksandra S. Kołodziejczyk,Kazimierz Wiśniewski |发布日期:2001.3.31
摘要:We Have Synthesised A Series Of New Chiral Type I Peptide Nucleic Acid Monomers In Total Yields Of 36-53%, Derived From Val, Ile, Ser(Bzl), Pro, And Trp, Employing Convenient Procedure.

合成参考文献


摘要:Meuleman, T. J.; Liskamp, R. M. J., Science of Synthesis, (2021) , 46.
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