CAS: 675126-08-6; Dasotraline Hydrochloride

上下游产品

(1R,4S)-N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-formamide N-((1S,4R)-1-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-4-yl)acetamide (4S)-4-(3,4-dichlorophenyl)-1-tetralone N-((1S,4R)-1-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-4-yl)acetamide

📜4-(3,4-二氯苯基)-1-四氢萘酮置于甲醇,Sodium Tetrahydroborate,三氟乙酸体系中,用 甲苯 作为反应溶剂,化学反应 74.5H,反应生成 (1R,4S)-4-(3,4-二氯苯基)-1,2,3,4-四氢-1-萘胺盐酸盐(1:1)
参考文献:Processes For The Preparation Of Dasotraline And Intermediates Thereof
标题:Processes For The Preparation Of Dasotraline And Intermediates Thereof
摘要:本发明提供了制备dasotraline(1)的工艺,以及在制备中有用的中间体.具体而言,提供了用于生产化合物formula(2)或其盐的工艺,以及其去保护以得到dasotraline(1)的工艺.

专利信息

专利号:EP-3800178-A1
优先权日:2019-10-01
标题:Preparation of enamide intermediate for the synthesis of dasotraline
发明人：BALLETTE ROBERTO; DOBARRO RODRÃ?GUEZ ALICIA
权利人:MOEHS IBERICA SL
摘要:The present invention relates to a process for the preparation of N -(( S )-4-(3,4-dichlorophenyl)-3,4-dihydronaphthalen-1-yl)acetamide, which is a suitable intermediate for the synthesis of dasotraline or a pharmaceutically acceptable salt thereof, as well as to a process for the preparation of dasotraline or a pharmaceutically acceptable salt thereof using said N -(( S )-4-(3,4-dichlorophenyl)-3,4-dihydronaphthalen-1-yl)acetamide intermediate.