CAS: 62402-24-8; Ethyl 2-((Pyridin-2-Ylmethyl)Amino)Acetate

相似化合物

820220-92-6 2444-13-5 6636-71-1

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2-(Aminomethyl)pyridine chloroacetic acid ethyl ester ethyl bromoacetate 2-Cyanopyridinea]pyrazin-4-one°Ctahydro-pyrido[1,2-a]pyrazin-4-one {[(4-benzothiazol-2-yl-phenylcarbamoyl)-methyl]-pyridin-2-ylmethyl-amino}-acetic acid ethyl ester 2-(N-isopropyl-N-((2-pyridyl)methyl)aminomethyl)-6-(N-(ethoxycarbonylmethyl)-N-((2-pyridyl)methyl)aminomethyl)-4-methylphenol diethyl 2,20-(2-hydroxy-5-methyl-1,3-phenylene)bis(methylene)bis((pyridin-2-ylmethyl)azanediyl)diacetate

📜Ethyl 2-(Pyridin-2-Ylmethylideneamino)Acetate置于sodium Tetrahydroborate体系中,化学反应生成 N-(2-吡啶甲基)甘氨酸乙酯
参考文献:Zn Ii配位球和化学结构对金属β-内酰胺酶模型化合物反应性的影响†
标题:Zn Ii配位球和化学结构对金属β-内酰胺酶模型化合物反应性的影响†
摘要:有系统地研究了第一个配位域对金属-β-内酰胺酶(mβl)单锌模型复合物的反应性和结构的影响.研究了三个具有三脚架配体的zn Ii配合物,它们形成了[zn(n-Nnn)],[zn(n-Nns)]和[zn(n-Nno)]系列,其中n-Nnx代表三脚架供体原子,模仿mβl的能力.该三脚架系列受到各自子类中mβl活性位点的启发,这些活性位点代表b1和b3子类中存在的(his,His,His)zn1位点,B3子类存在的(his,His,Asp)和硫醇盐. B1和b2网站.结果得到电子结构计算的支持.xas分析表明,Zn Ii电子缺陷的显着变化顺序为[zn(n-Nns)] <[zn(n-Nnn)] <[zn(n-Nno)].通过水解动力学观测到,该作用直接影响对硝基cefin和阿莫西林的反应性,其遵循相同的趋势.NMR光谱显示底物中的羧基与金属的配位相应地改变,从而影响水解动力学.我们的结果还表明,不
DOI:10.1039/c8Dt03905D

专利信息

专利号:US-2010022541-A1
优先权日:2006-09-25
标题:Chemical inhibitors of bacterial heptose synthesis, methods for their preparation and biological applications of said inhibitors
发明人：ESCAICH SONIA; DENIS ALEXIS; MOREAU FRANCOIS; GERUSZ VINCENT; DESROY NICOLAS
权利人:ESCAICH SONIA; DENIS ALEXIS; MOREAU FRANCOIS; GERUSZ VINCENT; DESROY NICOLAS
摘要:The invention relates to new compounds having heptose synthesis inhibitory properties, of formula (I) or a pharmaceutically acceptable salt, or prodrug thereof, wherein A is an aryl or heterocycle, optionally substituted by one or several identical or different R such as H, C1-C10 alkyl, C1-C10 alkyl-OR 1 , C1-C10 alkyl-NR 1 R 1 , alkoxy, hydroxy, thioalkyl, aryl, heterocycle, halogen, nitro, cyano, CO 2 R 1 , NR 1 R 1 , NR 1 C(O)R 1 , C(O)NR 1 R 1 , NR 1 C(S)R 1 , C(S)NR 1 R 1 , SO 2 NR 1 R 1 , SO 2 R 1 , NR 1 SO 2 R 1 , NR 1 C(O)NR 1 R 1 , NR 1 C(O)OR 1 , NR 1 C(S)NR 1 R 1 , NR 1 C(S)OR 1 , R 1 Câ•?NOR 1 , C(O)R 1 , aryloxy, thioaryl, alkenyl, alkynyl R1 identical or different is H or C1-C10 alkyl B 1 , B 2 , B 3 identical or not represent C, N, O, S to form a five-membered aromatic ring wherein from one to three carbon atoms are replaced by a heteroatom selected from S, O, N optionally substituted by one or several identical or different R such as defined above B 4 is C or N Y is H, C1-C10 alkyl, alkoxy, thio-alkyl, optionally substituted by one or several identical or different R such as defined above W is C, O or N, substituted or not by one or several C1-C10 alkyl radicals D is an heterocycle optionally substituted by one or several identical or different R such as defined aboe.

专利号:RU-2092491-C1
优先权日:1990-05-14
标 题 :Peptide derivatives or their pharmaceutically acceptable salts, method of synthesis of peptide derivatives and pharmaceutical composition

专利号:AU-2007301607-A1
优先权日:2006-09-25
标 题 :Substituted heterocyclylcarbonylamino-acetic-acid-derivatives as inhibitors of bacterial heptose synthesis, methods for their preparation and biological applications of said inhibitors

专利号:CA-2664342-A1
优先权日:2006-09-25
标题:New chemical inhibitors of bacterial heptose synthesis, methods for their preparation and biological applications of said inhibitors

专利号:EP-2104671-A2
优先权日:2006-09-25
标题:Substituted heterocyclylcarbonylamino-acetic-acid-derivatives as inhibitors of bacterial heptose synthesis, methods for their preparation and biological applications of said inhibitors

专利号:WO-2008038136-A2
优先权日:2006-09-25
标题 :Substituted heterocyclylcarbonylamino-acetic-acid-derivatives as inhibitors of bacterial heptose synthesis, methods for their preparation and biological applications of said inhibitors