CAS: 621-95-4; 4,4'-(Ethane-1,2-Diyl)Dianiline

上下游产品

1,2-bis(4-nitrophenyl)ethane p-toluidinep-toluidine 1,1'-(1,2-ethanediyl)bisbenzene ethanol N,N'-bibenzyl-4,4'-diyl-bis-benzenesulfonamideN,N'-bibenzyl-4,4'-diyl-bis-benzenesulfonamide 4,4'-ethylenediphenol 4,4'-ethanediyl-bis-cyclohexylamine N-(4-{2-[4-(Ethoxyoxalyl-amino)-phenyl]-ethyl}-phenyl)-oxalamic acid ethyl ester

4,4'-Dinitro Stilbene置于palladium 10% On Activated Carbon,氢气体系中,化学反应生成 4,4'-二氨基联苄
参考文献:针对多药耐药金黄色葡萄球菌的第二代芳基异腈化合物.
标题:针对多药耐药金黄色葡萄球菌的第二代芳基异腈化合物.
摘要:抗生素耐药性仍然是全球主要的公共卫生威胁,需要不断发现具有未开发脚手架的新型抗菌剂.我们合成的第一代芳基异腈化合物的结构活性关系导致了一个最初的先导分子,该分子指导了第二代芳基异腈的合成.在这个由20种化合物组成的新系列中,三种类似物可抑制耐甲氧西林的金黄色葡萄球菌(mrsa)(从1至4 µm)的生长,并且对人角质形成细胞安全.与第一代先导化合物相比,具有额外的异腈基的化合物19表现出对mrsa改善的活性.该化合物成为值得进一步研究的候选化合物,并进一步增强了异腈功能在该化合物的抗mrsa活性中的重要性.在鼠类皮肤伤口模型中,19与抗生素夫西地酸相似,可显着降低mrsa的负担.总之,已鉴定出19种化合物对mrsa有效.
DOI:10.1016/j.Bmc.2019.03.034

专利信息

专利号:US-11406964-B2
优先权日:2018-03-28
标题 :Heterogeneous catalysts for the synthesis of carbamates
发明人：WERSHOFEN STEFAN; VIDAL-FERRAN ANTON; RICO JOSÉ LUIS NÚÑEZ; PEREZ-RAMIREZ JAVIER; PUERTOLAS LACAMBRA BEGONA; AMRUTE AMOL P
权利人:COVESTRO INTELLECTUAL PROPERTY GMBH & CO KG
摘要:The present invention relates to a catalyst for preparing carbamates, in particular aromatic carbamates, comprising a binary oxide having the formula L1-xMxO2, wherein L is a metal selected from the lanthanoid series and M is a metal selected from the group consisting of Sc, Y, Ti, Zr, Hf, metals from the lanthanoid series and metals from the actinoid series, and wherein x ranges from 0.01 to 0.05. The present invention also relates to a method for producing said catalysts and a method of utilizing said catalysts in the production of carbamates, in particular aromatic carbamates.

专利号:US-2009111737-A1
优先权日:1999-05-24
标题:Novel antibacterial agents
发明人：CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
权利人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
摘要:This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands hasn a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.

专利号:US-2013102730-A1
优先权日:2010-04-02
标 题:Polyamine-containing polymers and methods of synthesis and use
发明人：JOST ROBERT W; ULUDAG HASAN; BOLUK MEHMET YAMAN
权利人:JOST ROBERT W; ULUDAG HASAN; BOLUK MEHMET YAMAN; ALBERTA INNOVATES TECHNOLOGY FUTURES
摘要:The present invention relates to polyamine-containing polymers and methods of their synthesis and use. The polymer may be hydroxyethylcellulose, dextran, poly(vinyl alcohol) or poly(methyl acrylate).

专利号:US-2024279231-A1
优先权日:2021-05-20
标题:Map4k4 inhibitors and methods of synthesis and use thereof
发明人：AWASTHI VIBHUDUTTA; EEDA VENKATESWARARAO
权利人:UNIV OKLAHOMA
摘要:The compound DMX-5804, IUPAC name 5-(4-(2-methoxyethoxy)phenyl)-7-phenyl-3,4a,7,7a-tetrahydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, is a potent and selective inhibitor of mitogen-activated protein kinase kinase kinase kinase-4 (MAP4K4). The present disclosure describes a scalable and practical synthesis process for making DMX-5804. The process (1) doesn't rely on transition metals, (2) has reduced duration of reactions, (3) is streamlined with significantly improved yields using low cost raw materials, (4) includes no microwave-assisted reactions, (5) does not require column purification, and (6) generally results in crystalized products having over a 95% purity in each step. The present disclosure also describes DMX-5804 analogs and derivatives for use in inhibiting MAP4K4, and scalable and practical processes for making such DMX-5804 analogs.

专利号:US-2021053031-A1
优先权日:2018-03-28
标 题 :Heterogeneous catalysts for the synthesis of carbamates

专利号:JP-4120709-B2
优先权日:1995-11-07
标 题:Synthesis of organic diurethanes and / or polyurethanes and their use for the production of diisocyanates and / or polyisocyanates