CAS: 619-17-0; 2-Amino-4-Nitrobenzoic Acid

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CAS号62-23-7 对硝基苯甲酸 | CAS号610-30-0 2,4-二硝基苯甲酸 | CAS号99-60-5 2-氯-4-硝基苯甲酸 | CAS号951-97-3 2-乙酰氨基-4-硝基苯甲酸 | CAS号528-75-6 2,4-二硝基苯甲醛 | CAS号2879-79-0 N-(2-甲基-5-硝基苯基)乙酰胺 | CAS号611-03-0 2,4-二氨基苯甲酸 | CAS号99-55-8 2-氨基-4-硝基甲苯 | CAS号87840-68-4 diethyl 2-[(2,4... | CAS号65911-47-9 2-carbamoyl-4-n... | CAS号109466-84-4 2-氨基-4-硝基苯甲醛 | CAS号31930-18-4 2-氨基-4-硝基苯甲酰胺 | CAS号90004-09-4 7-氨基喹唑啉-4-醇 | CAS号87376-25-8 2-氨基-4-硝基苯腈 | CAS号20872-93-9 7-硝基喹唑啉-4(3H)-酮 | CAS号78468-34-5 2-氨基-4-硝基苯甲醇 | CAS号63480-10-4 4-硝基靛红酸酐 | CAS号591-27-5 间氨基苯酚 | CAS号619-19-2 4-硝基水杨酸 | CAS号1608-46-4 1,2-二碘-4-硝基苯

2-氨基-4-硝基甲苯置于盐酸,Potassium Permanganate,溶剂黄146体系中,用 水,乙腈 作为反应溶剂,化学反应 2.75H,反应生成 2-氨基-4-硝基苯甲酸
参考文献:喹唑啉-4-酮的功能化第1部分:由4-取代-2-氨基苯甲酸和pph3(scn)2合成新型7-取代-2-硫代喹唑啉-4-酮
标题:喹唑啉-4-酮的功能化第1部分:由4-取代-2-氨基苯甲酸和pph3(scn)2合成新型7-取代-2-硫代喹唑啉-4-酮
摘要:允许4-(硝基,氨基,乙酰氨基)-2-氨基苯甲酸与pph 3(scn)2反应并反应生成交联的7-硝基,7-乙酰氨基和7-氨基-2-硫代喹唑啉-4-酮分别.2-氨基苯甲酸第4位的取代基的性质对与pph 3(scn)2的环化反应的结果有重大影响.同样,在2-取代的喹唑啉-4-酮的7位上的取代基的性质显着影响了烷基化反应的难易程度.发现7-取代2-巯基喹唑啉-4-酮的烷基化选择性取决于卤代烷的性质和2位取代基的性质.
DOI:10.1002/jhet.1669

专利信息

专利号:US-6051704-A
优先权日:1996-07-22
标题:Synthesis of macrocyclic tetraamido-N ligands
发明人：GORDON-WYLIE SCOTT W; COLLINS TERRENCE J
权利人:UNIV CARNEGIE MELLON
摘要:New synthetic methods for the preparation of macrocyclic amido-N donor ligands are provided. The primary method of the present invention involves in general only two synthetic steps. In the first step, an α or β amino carboxylic acid is allowed to react with an optimal (approximately stoichiometric) amount of an activated malonate or oxalate derivative with mild heating. Upon completion of the double coupling reaction, hydrolysis of the reaction mixture yields a diamide containing intermediate (a macro linker). In the second step, stoichiometric amounts of a diamine, preferably an orthophenylene diamine, are added to the macro linker intermediate in the presence of a coupling agent and heat. This second double coupling reaction, is allowed to proceed for a period of time sufficient to produce a macrocyclic tetraamido compound. The substituent groups on the α or β amino carboxylic acid, the malonate, and the aryl diamine may all be selectively varied so that the resulting tetraamido macrocycle can be tailored to specific desired end uses. The macrocyclic tetraamide ligand may then be complexed with a metal, such as a transition metal, and preferably the middle and later transition metals, to form a robust chelate complex suitable for catalyzing oxidation reactions.

专利号:US-8772301-B2
优先权日:2009-12-18
标题 :Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof
发明人：HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D
权利人:HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are compounds and methods of synthesis thereof. The compounds set forth herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, neurodegenerative disorders, neuropsychiatric disorders, disorders of cognition, learning or memory, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds set forth herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

专利号:US-6011152-A
优先权日:1996-07-22
标 题 :Synthesis of macrocyclic tetraamido-N ligands

专利号:US-7071145-B2
优先权日:2001-09-25
标 题:Thermosensitive recording material, and synthesis method of oligomer composition for the recording material
发明人：MORITA MITSUNOBU; HAYAKAWA KUNIO; TORII MASAFUMI; NARUSE MITSURU
权利人:RICOH KK
摘要:A thermosensitive recording material comprising a thermosensitive layer provided on a substrate, and the thermosensitive layer comprises as main ingredients a leuco dye and a developer to make colored state of said leuco dye when heated, wherein the developer is an oligomer composition obtained from the reaction of a polyvalent isocyanate compound represented by following Formula (I) with an aromatic amine represented by following Formula (II); n nwhere X represents a try- or more-valent group, a represents an integer numeral of 3 or more, b and c represent respectively integer numerals in the range of 0 to 5 and they satisfy a relation of b+c=1 to 5, Z represents hydrogen atom, alkyl group, allyl group or aryl group, and the aryl group may include condensed ling structure thereof, and d represents an integer numeral in the range of 0 to 4. This developer shows excellent reliabilities of both image and background area, and also shows an excellent color-developing characteristics (color developing sensitivity and image density).

专利号:WO-2004076425-A1
优先权日:2003-02-21
标题:Improved synthesis of macrocyclic tetraamido compounds and new metal insertion process

专利号:US-2003153460-A1
优先权日:2001-09-25
标 题:Thermosensitive recording material, and synthesis method of oligomer composition for the recording material