专利号:US-2023339844-A1 优先权日:2020-09-17 标题:A process for the synthesis of anthranilic acid/amide compounds and intermediates thereof 发明人:MAHAPATRA TRIDIB; PATRA PRANAB KUMAR; KLAUSENER ALEXANDER G M; MAL SANJIB; SHARMA RAJU 权利人:PI INDUSTRIES LTD; PI INDUSTRIES LTD 摘要:The present invention disclosed a process for the synthesis of compound of formula (Z) or a salt thereof, n n n n n n n n n n wherein, R, R 1 , R 2 , R 3 and R 10 are as defined in the detailed description. The process further comprises the synthesis of an anthranilic diamide compound of formula (I).
专利号:US-2023348492-A1 优先权日:2020-05-04 标题:Photochemical synthesis of marmycin analogues through a new photochemical reaction involving carbonyl compounds 发明人:SIVAGURU JAYARAMAN; KANDAPPA SUNIL KUMAR; VALLOLI LAKSHMY KANNADI 权利人:BOWLING GREEN STATE UNIV 摘要:Photochemical reactivity of carbonyl compounds leading to the synthesis of the Marmycin core is described. The photochemical reactivity involves an excited state reaction that provides convenient access to bicyclic compounds. The disclosed reactivity is a new photochemical pathway involving 1,3-dicarbonyl compounds and amines as well as for enaminones.
专利号:US-4879389-A 优先权日:1986-06-25 标题:Chiral phosphinopyrrolidine compounds and their use for asymmetric synthesis of optically active compounds 发明人:ACHIWA KAZUO 权利人:ACHIWA KAZUO 摘要:New chiral phosphinopyrrolidine compounds of the general formula: (I) or (I') wherein R1 is a hydrogen atom, -COR, -COOR, -CONHR or -SO2-R where R is an alkyl or aryl group, R2 and R3 each represents independently an aryl group which may have a substituent or substituents, and R4 and R5 each represents independently an aliphatic or cycloaliphatic hydrocarbyl group which may have a substituent or substituents, as well as the use of these compounds as ligand for a metal complex catalyst for asymmetric synthesis of optically active compounds. The new chiral phosphinopyrrolidine compounds are useful ligands which attain both of high optical yield and high reaction efficiency in catalytic asymmetric reduction.
专利号:EP-1383732-B1 优先权日:2001-05-04 标题:Labelling reagents, method for synthesis of said reagents and methods for detecting biological molecules 发明人:BOURGET CECILE; LHOMME JEAN; LAAYOUN ALI; KOTERA MITSUHARU; TREVISIOL EMMANUELLE; MENOU LIONEL; BERNAL MENDEZ ELOY 权利人:BIO MERIEUX; UNIV GRENOBLE 1; CENTRE NAT RECH SCIENT 摘要:The invention concerns a temperature-stable labelling reagent of formula (I), wherein: R<1> represents H or an alkyl, aryl or substituted aryl group; R<2> represents a detectable marker or at least two detectable markers linked together by at least a multimeric structure; L is a linking arm comprising a linear catemer concatenation of at least two covalent bonds; and n is an integer equal to 0 or 1; R<3> and R<4> represent, independently of each other: H, NO2, Cl, Br, F, I, R<2>-(L)n-Y-X-, OR, SR, NR2, R, NHCOR, CONHR, COOR with R = alkyl or aryl, A is a linking arm comprising at least a double bond enabling the conjugation of the diazo function with the aromatic cycle; and u is a whole number between 0 and 2, preferably between 0 and 1; and -Y-X- represents -CONH-, -NHCO-, -CH2O-, -CH2S-. The invention also concerns a method for the synthesis of said markers and uses for labelling biological molecules, in particular nucleic acids, with a labelling reagent bearing the diazomethyl function. The invention is particularly applicable in the field of diagnosis.
专利号:US-9150497-B2 优先权日:2011-10-14 标题 :Continuous two step flow synthesis of M-amino acetophenone 发明人:KULKARNI AMOL ARVIND; JOSHI RAMESH ANNA; JOSHI ROHINI RAMESH 权利人:COUNCIL SCIENT IND RES 摘要:Disclosed herein is a continuous tubular reactor based conversion of acetophenones to amino substituted acetophenones wherein the nitration is carried out at −10 to 10° C. followed by reduction to m-nitrophenone resulting in uniform output of product, said process comprising the steps of: a) Nitrating acetophenone with nitrating agent (nitration mixture or fuming nitric acid) at −10 to 10° C.; b) Isolating m-nitro acetophenone from a mixture of o and m-nitro acetophenone and c) Reducing the m-nitro to obtain m-amino acetophenone.
专利号:US-4894456-A 优先权日:1987-03-31 标题 :Synthesis of camptothecin and analogs thereof 发明人:WALL MONROE E; WANI MANSUKH C; NICHOLAS ALLAN W; MANIKUMAR GOVINDARAJAN 权利人:RES TRIANGLE INST 摘要:A method for synthesizing camptothecin and camptothecin analogs using a novel hydroxyl-containing tricyclic intermediate and the camptothecin analogs produced by the process. The camptothecin analogs are effective inhibitors of topoisomerase I and show anti-leukemic and anti-tumor activity.