CAS: 58530-13-5; 3-Bromo-5-Methylbenzoic Acid

该化合物是一种溴化芳烃色色色酸衍生物,其分子式为C8H7BRO2,该化合物的特点是3级以溴原子取代苯并酸核心,5级以甲基组为替代,为进一步功能化提供了不同的再活动性.其高纯度(>97%)和明确界定的结构使它成为制药合成,农用化学开发和材料科学应用中的宝贵中间体.溴基替代成分能够产生选择性的交叉反应(如铃木或赫克反应),而碳箱酸组则提供了恐吓或酯化的多功能.其晶体形式保证了标准储存条件下的良好稳定性,而甲基组则提高了脂性,从而改善了有机溶剂中的溶性.这一化合物对于制造需要精确再生化学控制的复杂分子特别有用.

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欧盟法规

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上下游产品

CAS号648439-19-4 3-溴-5-甲基苯甲醇 | CAS号556-96-7 5-溴间二甲苯 | CAS号2941-78-8 2-氨基-5-甲基苯甲酸 | CAS号13091-43-5 2-氨基-3-溴-5-甲基苯甲酸 | CAS号108938-16-5 7-溴-5-甲基吲哚啉-2,3-二酮 | CAS号124807-88-1 2-bromo-4-methy... | CAS号124289-21-0 3-溴-5-甲基苯腈 | CAS号7697-37-2 硝酸 | CAS号478375-40-5 3-溴-5-甲基苯甲酸甲酯 | CAS号1007578-82-6 3-溴-5-甲基苯甲酰胺 | CAS号124289-21-0 3-溴-5-甲基苯腈 | CAS号18595-15-8 3-氨基-5-甲基苯甲酸甲酯 | CAS号124289-24-3 3-溴-5-(溴甲基)苄腈 | CAS号612834-81-8 3-溴-5-甲基苯甲酸乙酯

合成工艺路线路线简述

    📜2-Bromo-4-Methyl-α-Isonitrosoacetanilide置于呋喃,盐酸,硫酸,双氧水,Methyloxirane,亚硝酸异戊酯体系中,用 甲醇,1,2-二氯乙烷 作为反应溶剂,化学反应 1.0H,反应生成 3-溴-5-甲基苯甲酸
    参考文献:Ghisalberti,Emilio L.; Jefferies,Phillip R.; Mori,Trevor A.,Journal Of Chemical Research,Miniprint,1993,# 12,P. 3155-3172
    标题:Ghisalberti,Emilio L.; Jefferies,Phillip R.; Mori,Trevor A.,Journal Of Chemical Research,Miniprint,1993,# 12,P. 3155-3172

    海关参考信息

    专利信息


    专利号:US-11299484-B2
    优先权日:2018-10-10
    标 题 :Inhibiting fatty acid synthase (FASN)
    发明人:MARTIN MATTHEW W; ZABLOCKI MARY-MARGARET; MENTE SCOT; DINSMORE CHRISTOPHER; WANG ZHONGGUO; ZHENG XIAOZHANG
    权利人:FORMA THERAPEUTICS INC
    摘要:The present disclosure is directed to inhibitors of FASN. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of FASN. For instance, the disclosure is concerned with compounds and compositions for inhibition of FASN, methods of treating, preventing, or ameliorating diseases or disorders associated with the inhibition of FASN, and methods of synthesis of these compounds.

    专利号:US-9303000-B2
    优先权日:2011-01-17
    标 题 :Olefin containing nuclear transport modulators and uses thereof
    发明人:SANDANAYAKA VINCENT P; SHACHAM SHARON; SHECHTER SHARON; MCCAULEY DILARA
    权利人:SANDANAYAKA VINCENT P; SHACHAM SHARON; SHECHTER SHARON; MCCAULEY DILARA; KARYOPHARM THERAPEUTICS INC
    摘要:The invention generally relates to the field of nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to new substituted-heterocyclic azole compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity such as in treating cancer and other neoplastic disorders, inflammatory diseases, disorders of abnormal tissue growth and fibrosis including cardiomyopathy, pulmonary fibrosis, hepatic fibrosis, glomerulonephritis, and other renal disorders, and for the treatment of viral infections (both acute and chronic).

    专利号:US-7825149-B2
    优先权日:2006-01-19
    标 题 :Substituted imidazoles
    发明人:CHUBB NATHAN ANTHONY LOGAN; COX MARK ROGER; DAUVERGNE JEROME SEBASTIEN; EWIN RICHARD ANDREW; LAURET CHRISTELLE
    权利人:PFIZER LTD
    摘要:This invention relates to a range of alpha substituted 2-benzyl substituted imidazole compounds and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes for their synthesis and their use as parasiticides.

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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Li, Y.; Fang, X.; Wang, Y., Science of Synthesis: DNA-Encoded Libraries, (2024) nan, 14.
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