CAS: 5780-66-5; Pyrazine-2-Carbaldehyde

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CAS号6164-79-0 2-吡嗪羧酸甲酯 | CAS号67936-72-5 2-(diethoxymeth... | CAS号593-56-6 甲氧胺盐酸盐 | CAS号98-97-5 2-吡嗪羧酸 | CAS号107-15-3 乙二胺 | CAS号56-81-5 甘油 | CAS号6705-33-5 2-羟甲基吡嗪 | CAS号109-08-0 2-甲基吡嗪 | CAS号64-19-7 冰醋酸 | CAS号123-32-0 2,5-二甲基吡嗪 | CAS号111759-98-9 2-(difluorometh... | CAS号6705-27-7 (E)-3-pyrazin-2... | CAS号51392-75-7 [1,2,3]Triazolo...

2-甲基吡嗪置于叔丁基过氧化氢,Selenium(Iv) Oxide体系中,用 1,4-二氧六环 作为反应溶剂,化学反应 3.0H,以11%的收率获得产物2-吡嗪甲醛
参考文献:在叔丁基过氧化氢存在下,二氧化硒对 N-杂芳族化合物活性甲基的氧化作用得到改善
标题:在叔丁基过氧化氢存在下,二氧化硒对 N-杂芳族化合物活性甲基的氧化作用得到改善
摘要:在二恶烷中存在叔丁基过氧化氢的情况下,使用seo 2 对包括双环和单环化合物在内的n-杂芳族化合物的活性甲基的氧化得到显着改善,从而以中等至非常好的收率获得产物相应的醛或羧酸.与没有叔丁基过氧化氢的常规seo 2 氧化相比,本氧化进行更温和和更有选择性地形成醛而不是羧酸.
DOI:10.3987/com-02-9702

专利信息

专利号:US-8378099-B2
优先权日:1994-10-28
标 题:Boronic ester and acid compounds, synthesis and uses
发明人：ADAMS JULIAN; MA YU-TING; STEIN ROSS L; BAEVSKY MATTHEW; GRENIER LOUIS; PLAMONDON LOUIS
权利人:MILLENNIUM PHARMACUETICALS INC; ADAMS JULIAN; STEIN ROSS L; BAEVSKY MATTHEW; GRENIER LOUIS; PLAMONDON LOUIS
摘要:Disclosed herein is a method for reducing the rate of degradation of proteins in an animal, comprising contacting cells of the animal with certain boronic ester and acid compounds. Also disclosed herein are novel boronic ester and acid compounds, their synthesis and uses.

专利号:US-6967107-B2
优先权日:2004-02-12
标 题 :N-aryl-carbamic acid ester-derived and valeric acid ester-derived cross-linkers and conjugates, and methods for their synthesis and use
发明人：BUECHLER KENNETH F; BANASZCZYK MARIUSZ G; NOAR JOSEPH BARRY
权利人:BIOSITE INC
摘要:The present invention describes carbamic acid ester-derived and valeric acid ester-derived polyfunctional cross-linker molecules, and methods for their synthesis and use. The inclusion of polymeric moieties such as poly(alkylene oxide) in the cross-linkers of the present invention can provide advantageous solubility properties in aqueous environments. Such cross-linkers may be used to form conjugates for use in a variety of assay formats.

专利号:US-7612106-B2
优先权日:2004-12-23
标题 :Fused pyrazole derivatives and methods of treatment of metabolic-related disorders thereof
发明人：BOATMAN P DOUGLAS; SCHRADER THOMAS O; SEMPLE GRAEME; SKINNER PHILIP J; JUNG JAE-KYU
权利人:ARENA PHARM INC
摘要:The present invention relates to certain fused pyrazole derivatives of Formula (Ia), and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists for the RUP25 receptor. n nAlso provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like. In addition, the present invention also provides for the use of the compounds of the invention in combination with other active agents such as those belonging to the class of α-glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors, squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers, DP receptor antagonists, and the like.

专利号:US-10906888-B2
优先权日:2016-07-14
标 题:Pyrimidine carboxamides as inhibitors of Vanin-1 enzyme
发明人：CASIMIRO-GARCIA AGUSTIN; STROHBACH JOSEPH WALTER; HEPWORTH DAVID; LOVERING FRANK ELDRIDGE; CHOI CHULHO; ALLAIS CHRISTOPHE PHILIPPE; WRIGHT STEPHEN WAYNE
权利人:PFIZER
摘要:Compounds, pharmaceutically acceptable salts thereof, are disclosed wherein the compounds have the structure of (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-10253004-B2
优先权日:2017-01-26
标 题:Indanylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
发明人：ECKHARDT MATTHIAS; WAGNER HOLGER; PETERS STEFAN
权利人:BOEHRINGER INGELHEIM INT
摘要:The present invention relates to compounds of formula I, n nwherein the groups R, R 1 , R 2 , R 3 , m and n are defined herein, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2. Furthermore, the invention relates to novel intermediates, useful for the synthesis of compounds of formula I.

专利号:US-4656291-A
优先权日:1985-03-15
标 题 :Process for producing amidine sulfonic acids
发明人：MARYANOFF CYNTHIA A; PLAMPIN JAMES N; STANZIONE ROBIN C
权利人:MCNEILAB INC
摘要:An efficient synthesis of quanidines, e.g. of the formula (III), by oxidizing a thiourea, e.g. of the following formula (II): with H2O2 and a molybdenum catalyst to yield an aminoiminomethane sulfonic acid which can then be reacted with an amine followed by optional transamination steps.