CAS: 570403-04-2; 5,6-Dichloro-N-(4-(4-Chlorothiophen-2-yl)-5-(4-Cyclohexylpiperazin-1-yl)Thiazol-2-yl)Nicotinamide
- 英文名称5,6-Dichloro-N-(4-(4-Chlorothiophen-2-yl)-5-(4-Cyclohexylpiperazin-1-yl)Thiazol-2-yl)Nicotinamide
- 中文名称5,6-二氯-N-(4-(4-氯噻吩-2-基)-5-(4-环己基哌嗪-1-基)噻唑-2-基)烟酰胺
- IUPAC名称5,6-dichloro-N-(4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)nicotinamide
- 其它别名5,6-Dichloro-N-(4-(4-Chlorothiophen-2-yl)-5-(4-Cyclohexylpiperazin-1-yl)Thiazol-2-yl)Nicotinamide; 3-Pyridinecarboxamide, 5,6-Dichloro-N-[4-(4-Chloro-2-Thienyl)-5-(4-Cyclohexyl-1-Piperazinyl)-2-Thiazolyl]-; Avatrombopag Impurity 14; 5,6-Dichloro-N-[4-(4-Chlorothiophen-2-yl)-5-(4-Cyclohexylpiperazin-1-yl)-1,3-Thiazol-2-Yl]Nicotinamide; 5,6-Dichloro-N-(4-(4-Chlorothiophen-2-yl)-5-(4-Cyclohexylpiperazin-1-yl)Thiazol-2-yl)Nicotinamide (Avatrombopag Impurity); Avatroposide Impurities20; Avatrapa Impurity 14; Avatrapa Impurity 12
- CAS编号570403-04-2
- 分子式:C23H24Cl3N5OS2分子量:556.97
- 产品CID: 2533134
- 产品分类分析化学 → 标准品 → 药典标准品和杂质标准品
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4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolamine 5,6-dichloronicotinic acid ethyl 1-(3-chloro-5-{[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl]carbamoyl}pyridin-2-yl)piperidine-4-carboxylate合成工艺路线路线简述
📜4-(4-Chloro-2-Thienyl)-5-(4-Cyclohexyl-1-Piperazinyl)-2-Thiazolamine,5,6-二氯烟酸置于吡啶,三氯氧磷体系中,用 乙腈 作为反应溶剂,化学反应 4.0H,以93.2%的收率获得产物5,6-二氯-N-(4-(4-氯噻吩-2-基)-5-(4-环己基哌嗪-1-基)噻唑-2-基)烟酰胺
参考文献:马来酸阿伐曲泊帕中间体的制备方法
标题:马来酸阿伐曲泊帕中间体的制备方法
摘要:本发明涉及一种马来酸阿伐曲泊帕中间体的制备方法,将中间体2,5,6‑二氯烟酸和吡啶在有机溶剂中,于‑10oc~20°C,滴加三氯氧磷反应得到中间体3;所述中间体2为4‑(4‑氯噻吩‑2‑基)‑5‑(4‑环己基哌嗪‑1‑基)‑1,3‑噻唑‑2‑胺,所述中间体3为5,6‑二氯‑n‑[4‑(4‑氯噻吩‑2‑基)‑5(4‑环己基哌嗪‑1‑基)‑1,3‑噻唑‑2‑基]吡啶‑3‑甲酰胺.本发明方法的污染小,制得中间体3的收率高且质量好.
参考文献:马来酸阿伐曲泊帕中间体的制备方法
标题:马来酸阿伐曲泊帕中间体的制备方法
摘要:本发明涉及一种马来酸阿伐曲泊帕中间体的制备方法,将中间体2,5,6‑二氯烟酸和吡啶在有机溶剂中,于‑10oc~20°C,滴加三氯氧磷反应得到中间体3;所述中间体2为4‑(4‑氯噻吩‑2‑基)‑5‑(4‑环己基哌嗪‑1‑基)‑1,3‑噻唑‑2‑胺,所述中间体3为5,6‑二氯‑n‑[4‑(4‑氯噻吩‑2‑基)‑5(4‑环己基哌嗪‑1‑基)‑1,3‑噻唑‑2‑基]吡啶‑3‑甲酰胺.本发明方法的污染小,制得中间体3的收率高且质量好.
