CAS: 5653-67-8; (2,3-Dimethoxyphenyl)Methanol

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CAS号86-51-1 2,3-二甲氧基苯甲醛 | CAS号1521-38-6 2,3-二甲氧基苯甲酸 | CAS号64-17-5 乙醇 | CAS号107290-27-7 (6-bromo-2,3-di... | CAS号3213-29-4 2,3-二甲氧基苯乙胺 | CAS号90-53-9 2,3-二甲氧基苯乙酸 | CAS号4463-33-6 2,3-二甲氧基甲苯 | CAS号109682-56-6 2,3-dimethoxybe... | CAS号86-51-1 2,3-二甲氧基苯甲醛 | CAS号3893-01-4 2,3-二甲氧基苄基氯 | CAS号7306-46-9 3,4-二甲氧基苄氯 | CAS号53663-28-8 2,3-二甲氧基苯甲酰基甲胺 | CAS号7035-02-1 2-甲氧基苄基氯

2,3-二甲氧基苯甲醛置于sodium Tetrahydroborate,乙醇体系中,用100 %的收率获得产物2,3-二甲氧基苄醇
参考文献:含氮二苯乙烯的设计,合成,细胞毒活性和计算机研究
标题:含氮二苯乙烯的设计,合成,细胞毒活性和计算机研究
摘要:在本研究中,设计,合成了五个系列的45种含氮二苯乙烯,包括35种新化合物,并测定了其对两种人肿瘤细胞系(k562细胞和mda-Mb-231细胞)和正常细胞系(l-02细胞)的细胞毒活性.).构效关系表明,N,N-二甲氨基的引入增强了对k562细胞的细胞毒性,并且含有n-甲基哌嗪的化合物对mda-Mb-231细胞表现出更强的效力.其中,化合物ns1I对k562细胞具有极强的细胞毒性,Ic 50值为0.93 μm,并且对正常细胞活力具有优异的选择性.此外,计算机靶点预测和分子对接证明醌还原酶2可能是ns1I的潜在靶点.总之,含氮二苯乙烯为发现新型高效抗癌药物提供了巨大的潜力,Ns1I可能作为一个有前景的先导化合物值得进一步研究.
DOI:10.1016/j.Fitote.2023.105625

专利信息

专利号:US-7056348-B2
优先权日:2001-04-19
标题:5-aryl-1,3,3-trimethyl-2-methylene-indoline derivatives and salts thereof, methods for the production and use of said compounds for the temporary coloration of fibers
发明人：SAUTER GUIDO; BRAUN HANS-JUERGEN; REICHLIN NADIA
权利人:WELLA AG
摘要:A method for the synthesis of 5-aryl-1,3,3,-trimethyl-2-methylene-indoline derivatives of Formula (I) or its salts of Formula (Ia) wherein 1 mole of a 5-aryl-2,3,3-trimethyl-3H-indole derivative of Formula (VII) is reacted for 1 to 44 hours at a temperature of 20° to 180° C. in an apolar, aprotic or polar, protic or polar aprotic solvent with 1 to 50 moles of a compound of Formula R1-A; new compounds of Formulas (I)/(Ia) and (V), obtainable by this method as well as an agent containing at least one compound of Formula (I)/(Ia) and a carbonyl/imine compound for dyeing keratinic fibers and a method for temporarily dyeing keratin fibers, for which the keratin fiber is dyed with the aforementioned agent and the dyeing, so obtained, is removed again at any later time by a sulfite preparation.

专利号:US-12215121-B2
优先权日:2020-12-29
标 题 :Linker structures with minimal scar for enzymatic synthesis
发明人：NGUYEN BICHLIEN HOANG; SMITH JAKE
权利人:MICROSOFT TECHNOLOGY LICENSING LLC
摘要:This disclosure provides electrochemically-cleavable linkers with cleavage potentials that are less than the redox potential of the solvent in which the linkers are used. In some applications, the solvent may be water or an aqueous buffer solution. The linkers may be used to link a nucleotide to a bound group. The linkers include a cleavable group which may be one of a methoxybenzyl alcohol, an ester, a propargyl thioether, or a trichloroethyl ether. The linkers may be cleaved in solvent by generating an electrode potential that is less than the redox potential of the solvent. In some implementations, an electrode array may be used to generate localized electrode potentials which selectively cleave linkers bound to the activated electrode. Uses for the linkers include attachment of blocking groups to nucleotides in enzymatic oligonucleotide synthesis.

专利号:US-11591361-B2
优先权日:2020-12-29
标 题 :Linker structures with minimal scar for enzymatic synthesis
发明人：NGUYEN BICHLIEN HOANG; SMITH JAKE
权利人:MICROSOFT TECHNOLOGY LICENSING LLC
摘要:This disclosure provides electrochemically-cleavable linkers with cleavage potentials that are less than the redox potential of the solvent in which the linkers are used. In some applications, the solvent may be water or an aqueous buffer solution. The linkers may be used to link a nucleotide to a bound group. The linkers include a cleavable group which may be one of a methoxybenzyl alcohol, an ester, a propargyl thioether, or a trichloroethyl ether. The linkers may be cleaved in solvent by generating an electrode potential that is less than the redox potential of the solvent. In some implementations, an electrode array may be used to generate localized electrode potentials which selectively cleave linkers bound to the activated electrode. Uses for the linkers include attachment of blocking groups to nucleotides in enzymatic oligonucleotide synthesis.

专利号:US-4565874-A
优先权日:1982-08-05
标题:Synthesis of parabactin and homologs thereof
发明人：BERGERON JR RAYMOND J
权利人:UNIV FLORIDA
摘要:A compound having the structural formula: ##STR1## wherein R is H or OH, and a is 3 or 4.

专利号:US-5405783-A
优先权日:1989-06-07
标 题 :Large scale photolithographic solid phase synthesis of an array of polymers

专利号:US-10112881-B2
优先权日:2014-07-21
标题:Skin lightening compounds
发明人：Huang cheng-chen; MONTE AARON P
权利人:WISYS TECH FOUNDATION INC
摘要:The present invention provides a compound of Formula I, n n n n n n n n n n n n wherein R 1 is not H when R 2 is H and R 2 is not H when R 1 is H, further wherein R 1 is C n H (2n+1) O, wherein n is 1-10, R 2 is OH or C n H (2n+1) O, wherein n is 1-10, A, B and R 1 , R 2 , R 5 , R 6 , and R 7 are separately and independently selected from a group consisting of H, alkyl, hydroxyl, halo, nitro and aryl groups, R 11 is an alkyl or an aryl group and L is an optional linker or linking group, with x=0 or 1, i.e., if x=0, no linking group is present, or a salt or prodrug or derivative thereof that is a skin-lightening agent useful for the inhibition of melanin synthesis and/or the removal of existing melanin to function as a skin-lightening agent.