CAS: 478-01-3; 2-(3,4-Dimethoxyphenyl)-5,6,7,8-Tetramethoxy-4H-Chromen-4-One

该化合物是一种从Citrus restitulata separ 中提取的自然产生的叶片. 它具有显著的抗氧化剂和抗炎特性,因此有可能成为开发针对各种疾病的新治疗剂的候选产品. 它独特的化学结构也显示出对致癌途径中某些酶的强烈抑制活动.

结构式图片

上下游产品

CAS号654083-34-8 1-(2-hydroxy-3,... | CAS号683278-67-3 5,8-dihydroxy-6... | CAS号77-78-1 硫酸二甲酯 | CAS号3162-28-5 1-(2-hydroxy-3,... | CAS号3535-37-3 3,4-二甲氧基苯甲酰氯 | CAS号333347-81-2 (1H-benzo[d][1,... | CAS号634-36-6 1,2,3-三甲氧基苯 | CAS号21450-56-6 1,2,3,4-四甲氧基苯 | CAS号13909-75-6 1,2,3,4,5-penta... | CAS号5333-45-9 1,2,3,5-四甲氧基苯 | CAS号2798-20-1 栀子黄素B | CAS号19103-54-9 三裂鼠尾草素 | CAS号21763-80-4 5-Desmethylsine... | CAS号479-90-3 艾黄素 | CAS号2174-59-6 去甲基川陈皮素 | CAS号1176-88-1 5-OH-HxMF | CAS号35154-55-3 柚皮黄素 | CAS号1178-24-1 3,3',4',5,6,7,8... | CAS号14786-40-4 1-(2,3,4,5,6-pe... | CAS号70460-32-1 4H-1-Benzopyran...

合成工艺路线路线简述

  • 合成目标产物 Nobiletin 主要起始原料 1,2,3-Trimethoxybenzene
  • (文献来源)合成步骤主要原料 1,2,3-Trimethoxybenzene
1-(2-羟基-3,4,5,6-四甲氧基苯基)乙-1-酮置于三氟乙酸,Lithium Hexamethyldisilazane体系中,用 四氢呋喃,甲醇 作为反应溶剂,化学反应 26.0H,反应生成 川陈皮素
参考文献:聚甲基化黄酮的实用合成:诺比列汀及其去甲基衍生物
标题:聚甲基化黄酮的实用合成:诺比列汀及其去甲基衍生物
摘要:我们提出了适用于一百克规模的聚甲氧基化柑桔黄酮nobiletin的实用合成方法.该化合物及其衍生物的现成可用性将有助于对其生物学活性的详细化学生物学研究,包括通过camp依赖性蛋白激酶a /细胞外信号相关蛋白激酶/ Camp反应元件结合蛋白途径激活信号.
DOI:10.1021/acs.Oprd.9B00091

海关参考信息

专利信息


专利号:US-2007232495-A1
优先权日:2006-03-24
标题:Compositions and methods to add value to plant products, increasing the commercial quality, resistance to external factors and polyphenol content thereof
发明人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
权利人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
摘要:The invention is related to compositions and methods that naturally protect plant tissues against ultraviolet radiation and temperature, thus giving protection against sunburn to plants, plant parts, fruits and/or flowers during their development. The invention is also related to compositions and methods to naturally improve the color of plants, plant parts, fruits and/or flowers by inducing the natural synthesis of flavonoids and anthocyanins present in plants. Likewise, the present invention is directed to improving the nutritional value of plants, plant parts, fruits and/or flowers by increasing the normal levels of polyphenolic compounds, especially flavonoids, present therein. Additionally, the present invention is related to compositions and methods that give more resistance to plants, plant parts, fruits and/or flowers against pathogens as bacteria and fungi. Finally, the present invention is related to plants, plant parts, fruits, flowers and/or propagating material treated with the compositions described in the present document.

专利号:WO-0007607-A1
优先权日:1998-08-04
标 题:Nutrient and therapeutic compositions for the treatment of cancer
权利人:KOSBAB JOHN V
摘要:This invention relates to nutrient and therapeutic compositions for the treatment of cancer symptoms and conditions. Compositions of this invention contain a mixture of antioxidants, components that promote collagen maintenance and synthesis, components that regulate blood lipids, glucose and/or insulin, and lower homocysteine levels. Compositions also provide supplementation for nutrient (vitamin, mineral and cofactor) deficiencies to restore and maintain normal biochemical function. Cancer formulations, particularly those adapted for treatment of female cancers, can be combined with components that provide benefit in osteoporosis.

专利号:US-2025231101-A1
优先权日:2024-01-11
标 题 :Validation of natural matrices for therapeutic use on humans, animals and plants on bio-physical bases as an alternative to validation through chemically definable substances derived from said matrices by isolation and/or synthesis processes and also as an alternative to products comprising natural matrices validated on the basis of their traditional use
发明人:MERCATI VALENTINO; LUCCI JACOPO
权利人:BIOS THERAPY PHYSIOLOGICAL SYSTEMS FOR HEALTH S P A
摘要:The present invention relates to a new method for assessing acceptability ranges or cut-offs for the compliance validation of batches of products comprising or consisting of one or more natural matrix, wherein said products have an ascertained therapeutic or beneficial effect. The invention also relates to a new process for the compliance validation of one or more batches of said products.

专利号:CN-114226746-A
优先权日:2021-12-17
标 题 :Method for green synthesis of gold nanoparticles by using orange peel extract under assistance of ultrasonic waves

专利号:CN-114226746-B
优先权日:2021-12-17
标 题 :An ultrasound-assisted method for green synthesis of gold nanoparticles from orange peel extract

专利号:WO-2020203947-A1
优先权日:2019-03-29
标题:Plant accumulating useful substance
发明人:OHTA DAISAKU; OKAZAWA ATSUSHI; OONISHI NOBORU
权利人:KIRIN HOLDINGS KK; UNIV OSAKA PUBLIC CORP; TAKENAKA CORP
摘要:The purpose of the present invention is to provide a plant having an improved production amount of a useful substance. The present invention is a method for producing a useful substance by cultivating a plant or the like in which the expression of a granule bound starch synthase (GBSS) gene and/or a starch branching enzyme (SBE) gene, which is a gene involved in starch synthesis, is suppressed, and inducing a lipid-storing organelle into a cell.
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✅ COA系统入驻 | 共享模式

主要参考文献


1: Gloston GF, Yoo SH, Chen ZJ. Clock-Enhancing Small Molecules and Potential Applications in Chronic Diseases and Aging. Front Neurol. 2017 Mar 15;8:100. doi: 10.3389/fneur.2017.00100. eCollection 2017. Review.
2: Oike H. Modulation of circadian clocks by nutrients and food factors. Biosci Biotechnol Biochem. 2017 May;81(5):863-870. doi: 10.1080/09168451.2017.1281722. Epub 2017 Jan 24. Review. Review. Epub 2016 Sep 27. Review.
5: Umeno A, Horie M, Murotomi K, Nakajima Y, Yoshida Y. Antioxidative and Antidiabetic Effects of Natural Polyphenols and Isoflavones. Molecules. 2016 May 30;21(6). pii: E708. doi: 10.3390/molecules21060708. Review. doi: 10.1146/annurev-nutr-071715-050718. Epub 2016 May 4. Review. doi: 10.2147/DDDT.S96936. eCollection 2016. Review.

合成参考文献


参考文献:10.1254/jphs.11001sc
摘要:Fujiwara H, Kogure A, Sakamoto M, Yamakuni T, Mimaki Y, Murata K, Hitomi N, Yamaguchi K, Ohizumi Y. Honeybee royal jelly and nobiletin stimulate CRE-mediated transcription in ERK-independent and -dependent fashions, respectively, in PC12D cells. J Pharmacol Sci. 2011;116(4):384–7. doi: 10.1254/jphs.11001sc.
参考文献:10.1002/jcb.23257
摘要:Lam KH, Alex D, Lam IK, Tsui SKW, Yang ZF, Lee SMY. Nobiletin, a polymethoxylated flavonoid from citrus, shows anti‐angiogenic activity in a zebrafish in vivo model and HUVEC in vitro model. J of Cellular Biochemistry. 2011 Oct 15;112(11):3313–21. doi: 10.1002/jcb.23257.
参考文献:10.1371/journal.pone.0021781
摘要:Kim Y, Hollenbaugh JA, Kim D, Kim B. Novel PI3K/Akt Inhibitors Screened by the Cytoprotective Function of Human Immunodeficiency Virus Type 1 Tat. PLoS ONE. 2011 Jul 12;6(7):e21781. doi: 10.1371/journal.pone.0021781.
参考文献:10.1021/np50001a002
摘要:Edwards JM, Raffauf RF, Le Quesne PW. Antineoplastic activity and cytotoxicity of flavones, isoflavones, and flavanones. J Nat Prod. 1979 Jan;42(1):85–91. doi: 10.1021/np50001a002.
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