CAS: 459-05-2; 1-(4-Fluorophenyl)-2-Thiourea

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CAS号399-07-5 Benzamide,N-[[(... | CAS号371-40-4 4-氟苯胺 | CAS号2146-07-8 4-氟苯胺盐酸盐 | CAS号1544-68-9 4-氟苯基异硫氰酸酯 | CAS号348-40-3 2-氨基-6-氟苯并噻唑 | CAS号33264-82-3 2-氨基-5-氟苯硫酚 | CAS号16194-64-2 Acetamide, N-(6... | CAS号82636-14-4 ethyl 1-(4-fluo...

4-氟苯胺置于sodium Hydroxide体系中,用 水,苯 作为反应溶剂,化学反应 2.33H,反应生成 1-(4-氟苯基)-2-硫脲
参考文献:取代的芳基噻唑基苯磺酰胺作为潜在的蛋白质酪氨酸磷酸酶1B抑制剂的合成,结构-活性关系和对接研究
标题:取代的芳基噻唑基苯磺酰胺作为潜在的蛋白质酪氨酸磷酸酶1B抑制剂的合成,结构-活性关系和对接研究
摘要:28比1:不错的赔率:酪氨酸磷酸酶1B(ptp1B)是治疗2型糖尿病的有希望的靶标.合成了芳基噻唑基苯基磺酰胺,并在体外针对ptp1B进行了筛选.然后在链脲佐菌素诱导的(stz)糖尿病大鼠模型中评估表现出> 48%抑制作用的化合物,从而鉴定出一种疗效与二甲双胍相当的化合物.最后,对接研究用于解释观测到的结构-活性关系.
DOI:10.1002/cmdc.201200197

专利信息

专利号:US-2008004415-A1
优先权日:2004-05-03
标题 :Non-linear optically active molecules, their synthesis, and use
发明人：MCGINNISS VINCENT D; RISSER STEVEN M; DROTLEFF ELIZABETH; JIANG EDWARD; SPAHR KEVIN B
权利人:OPTIMER PHOTONICS INC
摘要:In one aspect, the present invention provides a hyperpolarizable organic chromophore. The chromophore is a nonlinear optically active compound that includes a Ï€-donor conjugated to a Ï€-acceptor through a Ï€-electron conjugated bridge. In other aspects of the invention, donor structures and acceptor structures are provided. In another aspect of the invention, a chromophore-containing polymer is provided. In one embodiment, the chromophore is physically incorporated into the polymer to provide a composite. In another embodiment, the chromophore is covalently bonded to the polymer, either as a side chain polymer or through crosslinking into the polymer. In other aspects, the present invention also provides a method for making the chromophore, a method for making the chromophore-containing polymer, and methods for using the chromophore and chromophore-containing polymer.

专利号:US-4656291-A
优先权日:1985-03-15
标 题 :Process for producing amidine sulfonic acids
发明人：MARYANOFF CYNTHIA A; PLAMPIN JAMES N; STANZIONE ROBIN C
权利人:MCNEILAB INC
摘要:An efficient synthesis of quanidines, e.g. of the formula (III), by oxidizing a thiourea, e.g. of the following formula (II): with H2O2 and a molybdenum catalyst to yield an aminoiminomethane sulfonic acid which can then be reacted with an amine followed by optional transamination steps.

专利号:US-4781866-A
优先权日:1985-03-15
标题 :Process for producing amidine sulfonic acid intermediates for guanidines
发明人：MARYANOFF CYNTHIA A; PLAMPIN JAMES N; STANZIONE ROBIN C
权利人:MCNEILAB INC
摘要:An efficient synthesis of quanidines, e.g. of the formula (III), by oxidizing a thiourea, e.g. of the following formula (II): with H2O2 and a molybdenum catalyst to yield an aminoiminomethane sulfonic acid which can then be reacted with an amine followed by optional transamination steps.

专利号:US-2012059163-A1
优先权日:2005-04-28
标题 :Non-linear opticaly active molecules, their synthesis, and use
发明人：MCGINNISS VINCENT D; RISSER STEVEN M; DROTLEFF ELIZABETH; JIANG EDWARD; SPAHR KEVIN B
权利人:MCGINNISS VINCENT D; RISSER STEVEN M; DROTLEFF ELIZABETH; JIANG EDWARD; SPAHR KEVIN B; OPTIMER PHOTONICS INC
摘要:In one aspect, the present invention provides a hyperpolarizable organic chromophore. The chromophore is a nonlinear optically active compound that includes a Ï€-donor conjugated to a Ï€-acceptor through a Ï€-electron conjugated bridge. In other aspects of the invention, donor structures and acceptor structures are provided. In another aspect of the invention, a chromophore-containing polymer is provided. In one embodiment, the chromophore is physically incorporated into the polymer to provide a composite. In another embodiment, the chromophore is covalently bonded to the polymer, either as a side chain polymer or through crosslinking into the polymer. In other aspects, the present invention also provides a method for making the chromophore, a method for making the chromophore-containing polymer, and methods for using the chromophore and chromophore-containing polymer.

专利号:US-4851094-A
优先权日:1985-03-15
标 题:Process for producing amidine sulfonic acid intermediates for guanidines
发明人：MARYANOFF CYNTHIA A; PLAMPIN JAMES N; STANZIONE ROBIN C
权利人:MCNEILAB INC
摘要:An efficient synthesis of quanidines, e.g. of the formula (III), by oxidizing a thiourea, e.g. of the following formula (II): (III) (II) with H2O2 and a molybdenum catalyst to yield an aminoiminomethane sulfonic acid which can then be reacted with an amine followed by optional transamination steps.

专利号:CN-106674128-A
优先权日:2016-12-31
标题 :A class of licochalcone A thiouracil derivatives with anti-tumor activity and its synthesis method