CAS: 4016-63-1; 2-Amino-8-Bromo-9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-yl)-1H-Purin-6(9H)-One

相似化合物

13389-03-2 118-00-3 38819-10-2

上下游产品

CAS号118-00-3 鸟苷 | CAS号15717-45-0 (2R, 3R, 4R, 5R... | CAS号557-40-4 烯丙基醚 | CAS号126138-81-6 8-(烯丙氧基)鸟苷 | CAS号3868-31-3 8-羟基鸟苷 | CAS号3868-36-8 8-(苄氧基)鸟苷 | CAS号2104-66-7 2-amino-9-[3,4-... | CAS号118-00-3 鸟苷 | CAS号54898-41-8 8-Hydroxymethyl... | CAS号1439388-74-5 8-S-L-cysteinyl... | CAS号13389-05-4 2-amino-9-[3,4-... | CAS号13389-07-6 Guanosine,7,8-d...

鸟苷置于n-溴代丁二酰亚胺(Nbs)体系中,用 水,乙腈 作为反应溶剂,化学反应 0.5H,以78%的收率获得产物8-溴鸟苷
参考文献:鸟苷衍生物的自组装形成纳米结构和跨膜通道.
标题:鸟苷衍生物的自组装形成纳米结构和跨膜通道.
摘要:我们在此报告了均相溶液,固态和平面双层膜中亲脂性溴鸟苷衍生物(g1)的自组装.g1的自组装由h键和π-π堆叠相互作用驱动,可以根据孵育时间形成不同的纳米结构.该g1纳米结构是能够结合生物活性染料像玫瑰红.在晶体状态下,它显示出带状h键结图案,并在偏振光中表现出双折射.而且,G1的自组装纳米结构可以在脂质双层膜中形成离散的跨膜离子通道,从而使钾离子得以通过.
DOI:10.1002/chem.201800205

专利信息

专利号:US-12146136-B2
优先权日:2020-03-26
标题:Synthesis of modified oligonucleotides with increased stability
发明人：KHVOROVA ANASTASIA; ROUX LOÃ?C MAURICE RENÉ JEAN; YAMADA KEN
权利人:UNIV MASSACHUSETTS
摘要:This disclosure relates to the synthesis of novel modified oligonucleotides. The synthesis of novel phosphoramidites are also provided.

专利号:US-6069250-A
优先权日:1995-12-14
标 题 :Method and compositions for the synthesis of dioxolane nucleosides with β-configuration
发明人：MANSOUR TAREK; CIMPOIA ALEX; BEDNARSKI KRZYSZTOF
权利人:IAF BIOCHEM INT
摘要:The present invention relates to methods and compositions for preparing biologically important nucleoside analogues containing 1,3-dioxolane sugar rings. In particular, this invention relates to the stereoselective synthesis of the beta (cis) isomer by glycosylating the base with an intermediate of formula (II) below a temperature of about -10 DEG C. wherein R1 and L are as defined herein.

专利号:US-2023078498-A1
优先权日:2020-02-07
标题 :Targeted Translation of RNA with CRISPR-Cas13 to Enhance Protein Synthesis
发明人：ANDERSON DOUGLAS MATTHEW
权利人:UNIV ROCHESTER
摘要:The present disclosure provides proteins, nucleic acids, systems and methods for enhancing the synthesis of a protein.

专利号:US-2005080260-A1
优先权日:2003-04-22
标 题 :Preparation of prodrugs for selective drug delivery
发明人：MILLS RANDELL L; WU GUO-ZHANG
摘要:Synthesis of a chemical compound having the formula A-B-C that may serve for applications such as drug delivery where A is a chemiluminescent, moiety, B is a photochromic moiety, and C is a biologically active moiety where A-B-C may serve as a prodrug. Novel synthetic methods of the present invention to form the prodrug comprised the steps of (1) forming a benzophenone, (2) forming a diaryl ethylene, (3) attaching a phthalimide moiety to at least one of the aryl groups of the ethylene to form a phthalimide-ethylene conjugate, (4) condensing two ethylene-phthalimide conjugates to form a phthalimide-pentadiene conjugate, (5) converting the phthalimide to the phthalhydrazide by reaction with hydrazine to form a carrier compound according to the present invention, and (6) reacting the carrier compound with an nucleophilic moiety of the drug to form the corresponding prodrug. Alternatively the carrier can be prepared by using the halo-substituted diaryl ethylene to make the corresponding cationic leuco dye-like compound with known methods. The cationic compound then is protected by reacting with a nucleophile and coupled with the aminophathalimide by palladium-catalyzed amination to form the protected phthalimide-pentadiene conjugate. The latter is refluxed with hydrazine to convert its phthalimide to the phthalhydrazide and acidified to give the carrier. An additional aspect of the present invention relates to the use of these compounds as antiviral agents for the treatment of viral infections such as HIV and as anticancer agents for the treatment of cancers such as bowel, lung, and breast cancer.

专利号:US-10378035-B2
优先权日:2015-04-22
标 题 :Synthesis of transcripts using Syn5 RNA polymerase
发明人：ZHU BIN; RICHARDSON CHARLES C; TABOR STANLEY
权利人:HARVARD COLLEGE
摘要:Methods of in vitro transcription using cyanophage Syn5 RNA polymerase (RNAP) or mutants thereof and transcription conditions are provided.

专利号:US-9796978-B1
优先权日:2002-02-01
标 题:Oligonucleotide compositions with enhanced efficiency
发明人：WOOLF TOD; TAYLOR MARGARET
权利人:LIFE TECHNOLOGIES CORP
摘要:The oligonucleotide compositions of the present invention make use of combinations of oligonucleotides. In one aspect, the invention features an oligonucleotide composition including at least 2 different oligonucleotides targeted to a target gene. This invention also provides methods of inhibiting protein synthesis in a cell and methods of identifying oligonucleotide compositions that inhibit synthesis of a protein in a cell.