CAS: 3970-40-9; 2-Chloro-3-Nitrotoluene

上下游产品

CAS号13506-76-8 2-甲基-6-硝基苯甲酸 | CAS号570-24-1 2-甲基-6-硝基苯胺 | CAS号120-66-1 乙酰邻甲苯胺 | CAS号59907-22-1 2’-甲基-6’-硝基乙酰苯胺 | CAS号95-49-8 邻氯甲苯 | CAS号7697-37-2 硝酸 | CAS号3970-35-2 2-氯-3-硝基苯甲酸 | CAS号437-86-5 2-氟-3-硝基甲苯 | CAS号29027-17-6 2-氯-3-甲基苯胺 | CAS号54237-36-4 7-甲基苯并[d]噻唑-2(3H)-硫酮 | CAS号18102-29-9 2-甲基-6-硝基苯甲醚 | CAS号89642-16-0 1-(溴甲基)-2-氯-3-硝基苯 | CAS号96516-29-9 2-氟-3-硝基苯甲醛 | CAS号58755-57-0 2-氯-3-硝基苯甲醛 | CAS号108679-71-6 3-氨基-2-氯苯甲酸 | CAS号1885-76-3 2-甲基-6-硝基苯甲腈

2-甲基-6-硝基苯酚置于氯,苯基二氯化磷体系中,化学反应 5.0H,以85%的收率获得2-氯-3-硝基甲苯
参考文献:一种2-氟-3-硝基苯甲酸中间体原料的合成方法
标题:一种2-氟-3-硝基苯甲酸中间体原料的合成方法
摘要:本发明公开一种2‑氟‑3‑硝基苯甲酸中间体原料的合成方法.本发明提供了一种新颖的合成路线,能够从便宜,易得的原料快速方便地制备一种重要医药中间体.该工艺方法是从邻甲基苯酚开始,硝化反应选择性地生成关键中间体2‑甲基‑6‑硝基苯酚,羟基氯代生成2‑氯‑3‑硝基甲苯,然后通过氟代反应生成2‑氟‑3‑硝基甲苯,最后在氧化剂作用下甲基被氧化生成2‑氟‑3‑硝基苯甲酸.本工艺不仅产率高,而且也适合大规模生成.

专利信息

专利号:US-8188282-B2
优先权日:2006-07-15
标 题:Regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; HALLAND NIS; RKYEK OMAR; URMANN MATTHIAS
权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; HALLAND NIS; RKYEK OMAR; URMANN MATTHIAS; SANOFI AVENTIS
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct palladium catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides useful for the production of pharmaceuticals, diagnostic agents, liquid crystals, polymers, herbicides, fungicidals, nematicidals, parasiticides, insecticides, acaricides and arthropodicides.

专利号:WO-2017193288-A1
优先权日:2016-05-10
标题:Synthesis of phosphine ligands bearing tunable linkage: methods of their use in catalysis
发明人：KWONG FUK YEE; CHOY PUI YING; WU YINUO; YANG QINGJING
权利人:THE HONG KONG POLYTECHNIC UNIV SHENZHEN RESEARCH INSTITUTE
摘要:A series of novel linked indolyl phosphine ligands for transition metals, the synthesis thereof and their use in catalytic coupling reactions are provided. The ligands provide improvements of trasition-metal-catalyzed reactions, including the range of substrates scope, reaction conditions and efficieny.

专利号:US-12162815-B2
优先权日:2018-07-09
标 题 :Crystalline 2-fluoro-3-nitrotoluene and process for the preparation thereof
发明人：BRASOLA ELENA; DI SILVESTRO MARCO
权利人:F I S —FABBRICA ITALIANA SINTETICI S P A; AMGEN INC
摘要:The present invention refers to a crystalline 2-fluoro-3-nitrotoluene compound of formula (I), and a process for the preparation thereof. Furthermore, the present invention relates to a process for the synthesis of a compound of formula (II) or salts thereof by means of the crystalline 2-fluoro-3-nitrotoluene.

专利号:AU-2007276514-A1
优先权日:2006-07-15
标题:A regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles

专利号:CA-2657717-A1
优先权日:2006-07-15
标 题 :A regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles

专利号:CN-101490014-B
优先权日:2006-07-15
标 题:Regioselective palladium-catalyzed synthesis of benzimidazoles and azabenzimidazoles