CAS: 3900-89-8; (2-Chlorophenyl)Boronic Acid

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CAS号694-80-4 2-溴氯苯 | CAS号870195-94-1 2-氯苯硼酸频那醇酯 | CAS号36692-27-0 2-氯苯基溴化镁 | CAS号688-74-4 硼酸三丁酯 | CAS号13195-76-1 硼酸三异丁酯 | CAS号41019-43-6 5-(2-氯苯基)-2-糠酸 | CAS号34035-04-6 5-(2-氯苯基)糠醛 | CAS号31121-19-4 2,2'-二氯二苯二硫醚 | CAS号53824-24-1 2-(2-chlorophen... | CAS号484-17-3 9-菲酚 | CAS号208-37-7 Benzo[1,2-b:4,5... | CAS号19493-33-5 4-METHYL-2-CHLO... | CAS号553-03-7 3,4-二氢-2(1H)-喹啉酮 | CAS号95-57-8 邻氯苯酚

2-溴氯苯置于正丁基锂,硼酸三甲酯体系中,用 四氢呋喃,正己烷 用作溶剂,以56%的收率获得2-氯苯基硼酸
参考文献:5 / 6-芳基取代对衍生自4'-((2-丙基-1 H-苯并[ D ]咪唑-1-基)甲基)-[1,1'-联苯]-2-羧酸的药理作用的重要性pparγ激动剂
标题:5 / 6-芳基取代对衍生自4'-((2-丙基-1 H-苯并[ D ]咪唑-1-基)甲基)-[1,1'-联苯]-2-羧酸的药理作用的重要性pparγ激动剂
摘要:在此结构-活性关系研究中,位置5或6的芳基取代基对部分pparγ激动剂4'-(((2-丙基-1 H-苯并[ D ]咪唑-1-基]]甲基)的药理作用的影响研究了)-[1,1'-联苯]-2-羧酸.先前已将该铅鉴定为替米沙坦诱导pparγ激活的必要部分.第-och 3段-苯基取代大大增强了效价和功效,而与位置无关.由于与配体结合结构域中的氨基酸phe363有强疏水性接触,因此这两种化合物均代表完全的激动剂.获得了比替米沙坦或铅具有更高效能的部分激动剂,在苯环上带有oh或cl取代基.分子模型表明,位于螺旋7处的phe360具有额外的氢或卤素键.假定这些相互作用固定了螺旋7,从而促进了受体的部分激动剂构象.理论上的考虑与使用hpparγ-Lbd进行的萤光素酶反式激活分析以及时间分辨荧光共振能量转移(tr-Fret)分析的结果非常相关,在该方法中,共激活剂(trap220,
Doi:10.1016/j.Ejmech.2016.11.051

专利信息

专利号:US-8110642-B2
优先权日:2006-05-08
标 题:Synthesis of vinylphenylpyridine and living anionic polymerization
发明人：LEE JAE-SUK; KANG NAM-GOO
权利人:LEE JAE-SUK; KANG NAM-GOO; KWANGJU INST SCI & TECH
摘要:Provided are a vinyl-biphenylpyridine monomer and a polymer thereof. More particularly, the present invention provides a vinyl-biphenylpyridine monomer having a side chain of pyridine or phenylpyridine as a functional group, a homopolymer of which molecular weight and molecular weight distribution are controlled using the monomer, and a block copolymer of which molecular structure and molecular weight are controlled to facilitate synthesis of an organic metal complex. Accordingly, the present invention provides a vinyl-biphenylpyridine monomer and a polymer thereof which are effectively used as nano and optical functional materials.

专利号:US-2006089405-A1
优先权日:2004-10-21
标 题 :Asymmetric synthesis of dihydrobenzofuran derivatives
发明人：ZHOU DAHUI; STACK GARY P; GONTCHAROV ALEXANDER V
权利人:WYETH CORP
摘要:This invention concerns a process for the preparation of benzofuran derivatives. In some aspects, these compounds are of formula I: n n nwherein each of R 1 , R 2 , R 3 , and R 4 is as defined herein.

专利号:US-10385087-B1
优先权日:2018-04-26
标题:Xylose derivatives and process for preparation thereof
发明人：HWA KUO-YUAN
权利人:NATIONAL TAIPEI UNIV OF TECHNOLOG; UNIV NAT TAIPEI TECHNOLOGY
摘要:Disclosure of the present invention relates to a method for synthesis of a xylose derivative, which comprises protecting a xylose with a protective group, followed by incorporating to a halogen atom as a leaving group; removing the protective groups and using water-soluble ligands to carry out a Suzuki cross-couplings reaction with a palladium catalyst in a water solution. Ten new xylose derivatives as obtained by the method are also provided.

专利号:US-12150934-B2
优先权日:2016-11-30
标 题 :Methods of using substituted pyrazole and pyrazole compounds and for treatment of hyperproliferative diseases
发明人：SIDDIQUI ARSHAD M; CIBLAT STEPHANE; CONSTANTINEAU-FORGET LEA; GRAND-MAITRE CHANTAL; GUO XIANGYU; SRIVASTAVA SANJAY; SHIPPS GERALD W; COOPER ALAN B; OZA VIBHA; KOSTURA MATTHEW W; LUTHER MICHAEL; LEVINE JEDD
权利人:BANTAM PHARMACEUTICAL LLC
摘要:Disclosed are methods of treating hyperproliferative disorders such as cancer, methods of arresting the cell cycle in cancer cells, methods of inhibiting glutathione synthesis in cancer cells, and associated compounds for use and uses in medicaments. In certain embodiments, the methods, uses and compounds are provided with reference to compounds of the structural formula (I), in which X1, X2, Z1, Z2, the ring system denoted by “aâ€?, R1, L1, L2, Q, L3, R3, L4, R4, L5, and R5 are as described herein. In certain embodiments, compounds disclosed herein are especially active against cancers having a mutant KRAS gene.

专利号:US-2011301143-A1
优先权日:2009-02-23
标题 :Heterocyclic derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：ISABEL ELISE; LACHANCE NICOLAS; LECLERC JEAN-PHILIPPE; LEGER SERGE; OBALLA RENATA M; POWELL DAVID; RAMTOHUL YEEMAN K; ROY PATRICK; TRANMER GEOFFREY K; ASPIOTIS RENEE; LI LIANHAI; MARTINS EVELYN
权利人:ISABEL ELISE; LACHANCE NICOLAS; LECLERC JEAN-PHILIPPE; LEGER SERGE; OBALLA RENATA M; POWELL DAVID; RAMTOHUL YEEMAN K; ROY PATRICK; TRANMER GEOFFREY K; ASPIOTIS RENEE; LI LIANHAI; MARTINS EVELYN
摘要:Heterocyclic compounds of structural formula (I), or a pharmaceutically acceptable salt thereof, wherein W is a R1— substituted heteroaryl, R1 is an heteroaryl ring substituted with an ester or carboxylic acid containing radical, X-T is N—CR5R6, Câ•?CR5 or CR13—CR5R6, Y is a bond or —C(O)—, a and b represent an integer selected from 1 to 4, and Ar is an optionally substituted phenyl or naphtyl, are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD) The heterocyclic compounds are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, atherosclerosis, obesity, diabetes, neurological disease, Metabolic Syndrome, insulin resistance, cancer, liver steatosis, and non-alcoholic steatohepatitis.

专利号:US-2009105416-A1
优先权日:2006-05-08
标题:Synthesis of Vinylphenylpyridine and Living Anionic Polymerization