CAS: 35665-38-4; Fmoc-Gly-Gly-Oh

相似化合物

2566-19-0 31972-52-8 556-50-3

上下游产品

CAS号556-50-3 双甘肽 | CAS号28920-43-6 芴甲氧羰酰氯(Fm°C-Cl) | CAS号1131148-55-4 N-Fm°C-1H-benzo... | CAS号29022-11-5 Fm°C-甘氨酸 | CAS号56-40-6 甘氨酸 | CAS号113484-74-5 FM°C-甘氨酸羟基琥珀酰亚胺酯 | CAS号35661-61-1 1-(N-fluoren-9-...

在 三氟乙酸体系中,用 乙腈 作为反应溶剂,以59%的收率获得产物n-芴甲氧羰基-甘氨酰-甘氨酸
参考文献:甘氨酸依赖性酰胺形成连接的羟甲基水杨醛助剂
标题:甘氨酸依赖性酰胺形成连接的羟甲基水杨醛助剂
摘要:本文描述了在连接位点需要甘氨酸或伯胺的新的酰胺形成连接.这种连接的显着特征是它依赖于在c-末端的o-羟甲基水杨醛酯,它允许通过n,O-乙缩醛中间体形成天然的肽键.
DOI:10.1021/acs.Orglett.5B02350

专利信息

专利号:US-2025188118-A1
优先权日:2023-12-06
标题:Liquid phase peptide synthesis methods
发明人：BAUCOM KYLE; GLADFELDER JOSHUA; TURMAN NOLAN
权利人:AMGEN INC
摘要:Disclosed herein are methods of producing peptides, including liquid phase peptide synthesis methods in which one or more cycles of peptide elongation are performed in one pot. In particular, the present disclosure provides liquid phase peptide synthesis methods employing solvent systems comprising 2-methyltetrahydrofuran for condensation reactions, as well as convergent liquid phase peptide assembly methods in which benzyl alcohol anchor groups are selectively removed from an N-protected C-protected peptide by base-catalyzed ester hydrolysis.

专利号:WO-2023287345-A1
优先权日:2021-07-16
标 题 :Aqueous solid phase peptide synthesis
发明人：PAWLAS JAN; LUDEMANN-HOMBOURGER OLIVIER
权利人:POLYPEPTIDE LABORATORIES HOLDING PPL AB
摘要:The present invention relates to a solid phase peptide synthesis (SPPS) where the coupling of amino acids is performed in an aqueous solution comprising at least one organic co-solvent miscible with water. The aqueous solution is capable of sufficiently solubilize the activated Fmoc-α-amine protected amino acid or activated Fmoc-α-amine protected peptide fragment, and where the resin is capable of swelling in the presence of the aqueous solution above about 4 mLg-1. The invention also encompasses a method for regeneration of spent aqueous solution from the SPPS.

专利号:CN-115109118-A
优先权日:2021-03-19
标 题:A kind of method for solid-phase synthesis of DS-8201 intermediate and preparation method of DS-8201

专利号:CN-115073587-A
优先权日:2022-07-08
标 题 :A kind of synthetic process of semi-continuous liquid phase synthesis of bivalirudin

专利号:US-2017029467-A1
优先权日:2015-07-30
标 题:Method of producing bivalirudin
发明人：ZHANG GUOQING; ZHANG RUOPING; BAI JUNCAI
权利人:AMBIOPHARM INC
摘要:The present disclosure provides a method of producing bivalirudin using a peptide fragment or peptide fragments on solid phase peptide synthesis that minimizes, or eliminates, the production of bivalirudin molecules having too few or too many glycine residues.

专利号:US-5202418-A
优先权日:1990-02-02
标题 :Method of performing multiple synthesis of peptides on solid carrier