CAS: 347-93-3; 3-Chloro-4'-Fluoropropiophenone

该化合物是一种含氟芳香酮衍生物,可应用于有机合成和制药中间体,其主要结构特征包括反应性氯乙基基组和氟苯基混合物,这增强了其在核循环替代反应和作为生物活性化合物前体的效用;氟替代物有助于提高合成途径的稳定性和选择性;该化合物因其能够将卤素和碳基功能引入目标分子,在制药和农用化学品开发过程中特别有用;由于具有再活动性,通常在受控制的条件下处理,确保专门合成工艺的最佳性能.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

fluorobenzene 2-chloropropionyl chloride 1-Bromo-4-fluorobenzene 5-fluoro-1-indanone 1-(4-Fluorophenyl)-3-([N-[4-(2,2,2-trifluoro-1-hydroxy)-1-(trifluoromethyl)ethyl]phenyl]amino)-1-propanone 3-Decylamino-1-(4-fluoro-phenyl)-propan-1-one 6-fluoroindan-1-one

合成工艺路线路线简述

  • 合成目标产物 3-Chloro-4'-Fluoropropiophenone 主要起始原料 3-Chloropropionyl Chloride And 4-Bromofluorobenzene
  • (文献来源)合成步骤主要原料 3-Chloropropionyl Chloride 和 4-Bromofluorobenzene
📜氟苯 反应生成3'-氯-4-氟苯丙酮
参考文献:Preparation Of Fipamezole
标题:Preparation Of Fipamezole
摘要:该申请涉及制备非帕美唑及其药用盐的工艺,以及其中间体的制备方法.它还提供了公式iii和公式iv的中间化合物,以及它们的制备方法.

海关参考信息

专利信息


专利号:US-8487094-B2
优先权日:2008-07-25
标题 :Synthesis of inhibitors of 11β-hydroxysteroid dehydrogenase type 1
发明人：FANDRICK KEITH R; GAO JOE JU; LI WENJIE; LU ZHI-HUI; ZHANG YONGDA
权利人:FANDRICK KEITH R; GAO JOE JU; LI WENJIE; LU ZHI-HUI; ZHANG YONGDA; BOEHRINGER INGELHEIM INT
摘要:Disclosed are syntheses of 11β-HSD1 inhibitors and corresponding intermediates that are promising for the treatment of a variety of disease states including diabetes, metabolic syndrome, obesity, glucose intolerance, insulin resistance, hyperglycemia, hypertension, hypertension-related cardiovascular disorders, hyperlipidemia, deleterious gluco-corticoid effects on neuronal function (e.g. cognitive impairment, dementia, and/or depression), elevated intra-ocular pressure, various forms of bone disease (e.g., osteoporosis), tuberculosis, leprosy (Hansen's disease), psoriasis, and impaired wound healing (e.g., in patients that exhibit impaired glucose tolerance and/or type 2 diabetes).

专利号:WO-2009017671-A1
优先权日:2007-07-26
标题 :Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1

专利号:US-2010256363-A1
优先权日:2007-07-26
标题 :SYNTHESIS OF INHIBITORS OF 11ß-HYDROXYSTEROID DEHYDROGENASE TYPE 1

专利号:US-5075339-A
优先权日:1989-07-28
标 题:Benzylketone phospholipase A2 inhibitors
发明人：WILKERSON WENDELL W
权利人:DU PONT MERCK PHARMA
摘要:The invention relates to benzylketone phospholipase A2 inhibitors, pharmaceutical compositions containing them, and methods of treating phospholipase A2-mediated conditions in mammals by administration of a therapeutically effective amount of such a benzylketone phospholipase A2 inhibitor. These compounds are also intermediates in the synthesis of other PLA2 inhibitors.

专利号:US-2011269957-A1
优先权日:2008-07-25
标 题 :Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1

专利号:EP-2183229-B1
优先权日:2007-07-26
标 题 :Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1

其他信息查阅

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

实用工具

⚠️全国化工行业净网倡议书
📋制造商识别码
📖 海关编码查询
📝MSDS生成器

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献

参考标题:Construction Of N-Alkyl- And N-Arylaziridines From Unprotected Amines Via C-H Oxidative Amination Strategy
作者:Yang Yu,Meijuan Li,Yong Zhang,Yonghai Liu,Lei Shi,Wei Wang,Hao Li |发布日期:2019.2.15
摘要:A Copper-Promoted Intramolecular C-H Oxidative Amination Reaction Between Secondary Amine (N-H) And C(Sp3)-H At The Benzylic Position Of Azaarenes Or α-Position Of Ketones For The Synthesis Of Aziridine Derivatives Has Been Developed. Moreover, A Practical Annulation Of Electron-Deficient Vinylarenes With An Unprotected Primary Alkyl Amine By A Yb(Otf)3-Cui Relay System Has Also Been Reported. The

合成参考文献


摘要:Lipshutz, B. H.; Ghorai, S., Science of Synthesis Knowledge Updates, (2014) 2, 178.
📝 需求与反馈
尽可能描述清楚需求与问题信息
×

通知