CAS: 317319-21-4; Ethyl 2-(3-Fluoro-4-(Trifluoromethyl)Phenyl)-4-Methylthiazole-5-Carboxylate

该化合物是一种氟化二氮衍生物,在制药和农用化学研究中具有重大效用,其结构包括氟和三氟甲基组,加强了对生物活性分子设计至关重要的代谢稳定性和亲脂性.硫代醇核心为进一步功能化提供了多功能的手架,而酯细胞能允许直接衍生.由于该化合物的电提炼子体影响着捆绑性互动,该化合物在培养酶抑制剂和受体调节器方面特别有用.其高纯度和清晰的合成路线使它成为先进的化学合成的可靠中间体.

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物理性质

MSDS等安全信息

上下游产品

ethyl 2-chloro-3-oxo-butyrate 3-fluoro-4-(trifluoromethyl)thiobenzamide5-hydroxymethyl-4-methyl-2-[3-fluoro-4-(trifluoromethyl)phenyl]thiazole 5-chloromethyl-4-methyl-2-[3-fluoro-4-(trifluoromethyl)phenyl]thiazole GW 0742

合成工艺路线路线简述

    📜2-氯乙酰乙酸乙酯,3-氟-4-(三氟甲基)硫代苯甲酰胺 以 乙醇 作为反应溶剂,以65%的收率获得产物乙基2-[3-氟-(三氟甲基)苯基]-4-甲基-噻唑-5-羧酸酯
    参考文献:Novel Selective Small Molecule Agonists For Peroxisome Proliferator-Activated Receptor δ (Pparδ)-synthesis And Biological Activity
    标题:Novel Selective Small Molecule Agonists For Peroxisome Proliferator-Activated Receptor δ (Pparδ)-synthesis And Biological Activity
    摘要:We Report The Synthesis And Biological Activity Of A New Series Of Small Molecule Agonists Of The Human Peroxisome Proliferator-Activated Receptor Delta (Ppardelta). Several Hits Were Identified From Our Original Libraries Containing Lipophilic Carboxylic Acids. Optimization Of These Hits By Structure-Guided Design Led To 7K (Gw501516) And 71 (Gw0742),Which Shows An Ec50 Of 1.1 Nm Against Ppardelta With 1000-Fold Selectivity Over The Other Human Subtypes. (C) 2003 Elsevier Science Ltd. All Rights Reserved.
    DOI:10.1016/s0960-894X(03)00207-5

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    合成参考文献

    合成方法参考DOI号:10.1021/acs.jmedchem.1c00560
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