CAS: 23384-72-7; 1-(3,4-Difluorophenyl)Propan-1-One

上下游产品

3',4'-difluoroacetophenone N,N-dimethyl-formamide 3,4 difluorobenzaldehyde ortho-difluorobenzene 1-(3,4-difluoro-phenyl)-propan-1-one oxime H-imidazole-4-carboxylic acid methyl ester3-[1-(3,4-difluoro-phenyl)-propyl]-2-mercapto-3H-imidazole-4-carboxylic acid methyl ester [1-(3,4-difluoro-phenyl)-propylamino]-acetic acid methyl ester 2-bromo-1-(3,4-difluorophenyl)propan-1-one

📜1-(3,4-Difluorophenyl)Propan-1-Ol 以 二氯甲烷,Pyridinium Chlorochromate 用作溶剂,以69%的收率获得3,4-二氟苯丙酮
参考文献:Oxazolidinones As .Alpha..Sub.1A Receptor Antagonists
标题:Oxazolidinones As .Alpha..Sub.1A Receptor Antagonists
摘要:这项发明涉及氧唑啉酮化合物,这些化合物是人类α1A受体的选择性拮抗剂.这项发明还涉及利用这些化合物降低眼内压,抑制胆固醇合成,放松下尿路组织,治疗良性前列腺增生,阳痿,心律失常以及治疗任何需要α1A受体拮抗作用的疾病.该发明还提供了一种药物组合物,包括上述定义的化合物的治疗有效量和药用可接受载体.

专利信息

专利号:US-8981092-B2
优先权日:2008-09-19
标题 :Substituted 3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-ones as modulators of protein kinase activity
发明人：MIRIZZI DANILO; CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; FERGUSON RON; CASUSCELLI FRANCESCO
权利人:MIRIZZI DANILO; CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; FERGUSON RON; CASUSCELLI FRANCESCO; NERVIANO MEDICAL SCIENCES SRL
摘要:Compounds which are 4,7-disubstituted derivatives of 3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-one compounds, n nor pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders; also disclosed is a process under Solid Phase Synthesis conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

专利号:US-6620815-B1
优先权日:1997-06-18
标题:Oxazolidinones and uses thereof
发明人：LAGU BHARAT; DHAR T G MURALI; NAGARATHNAM DHANAPALAN; JEON YOON T; MARZABADI MOHAMMAD R; WONG WAI C; GLUCHOWSKI CHARLES
权利人:SYNAPTIC PHARMA CORP
摘要:This invention is directed to oxazolidinone compounds which are selective antagonists for human α 1A receptors. This invention is also related to uses of these compounds for lowering intraocular pressure, inhibiting cholesterol synthesis, relaxing lower urinary tract tissue, the treatment of benign prostatic hyperplasia, impotency, cardiac arrhythmia and for the treatment of any disease where the antagonism of the α 1A receptor may be useful. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.