专利号:EP-1493431-B1 优先权日:2003-07-03 标题:Use of an extract of bauhinia for the preparation of pharmaceutical and cosmetic compositions 发明人:WIRTH CORINNA DR; BUCHHOLZ HERWIG DR 权利人:MERCK PATENT GMBH 摘要:Use of an aqueous or aqueous-alcoholic extract (A) of Bauhinia is claimed to make a composition for cosmetic or pharmaceutical treatment of skin and hair. Use of an aqueous or aqueous-alcoholic extract (A) of Bauhinia is claimed to make a composition for: (a) care, preservation or improvement of the general condition of the skin or hair; (b) prevention and/or inhibition of the aging process for human skin or hair; (c) for promoting healing of wounds; (d) for prevention and/or treatment of skin diseases associated with abnormal keratinization, and (e) for prevention and/or treatment of all malignant or benign growths of the dermis or epidermis. An independent claim is also included for a composition containing (A). ACTIVITY : Dermatological; Vulnerary; Antiseborrheic; Antipsoriatic; Cytostatic; Antiinflammatory; Virucide. MECHANISM OF ACTION : Protein glycosylation inhibitor. In a test, human fibroblasts were cultured in the presence of Vitamin C to stimulate collagen synthesis, then lysed and labeled with tritiated glucose for 15 days, Proteins were removed, extraction and precipitation were carried and the amount of bound glucose measured by liquid scintillation counting. Addition of an aqueous-alcoholic extract of Bauhinia fortificata (0.03 mg/ml), reduced protein glycosylation to 55% of that in a control.
1: Bertella A, Smadi A, Benhabrou H, Salvador D, Wrona M, Oliveira H, Sidaoui A, Gavril-Luminita G, Pinto DCGA, Olewnik-Kruszkowska E, Nerín C, Silva AMS, Bitam F. Phytochemical Study and In Vitro Antioxidant Activity of Helianthemum cinereum Along with Antitumor Activity of the Isolated trans-Tiliroside and Luteolin 4'-O-β-Xyloside. Molecules. 2024 Dec 16;29(24):5935. doi: 10.3390/molecules29245935. 287:138590. doi: 10.1016/j.ijbiomac.2024.138590. Epub ahead of print. 15(11):2220-2236. doi: 10.4239/wjd.v15.i11.2220. 4: Feng X, Qin Y, Ma S, Ming S, Weng Z, Xuan Y, Gong S, Fan F, Chen P, Chu Q, Li Z. Liubao tea extract restrains obesity-related hyperlipidemia via regulation of AMPK/p38/NF-κB pathway and intestinal microbiota. Food Chem. 2025 Feb 1;464(Pt 3):141910. doi: 10.1016/j.foodchem.2024.141910. Epub 2024 Nov 5.
合成参考文献
参考文献:10.1021/np960057s 摘要:Lale A, Herbert JM, Augereau JM, Billon M, Leconte M, Gleye J. Ability of different flavonoids to inhibit the procoagulant activity of adherent human monocytes. J Nat Prod. 1996 Mar;59(3):273–6. doi: 10.1021/np960057s. 参考文献:10.1007/s00394-011-0204-5 摘要:Tsimplouli C, Demetzos C, Hadzopoulou-Cladaras M, Pantazis P, Dimas K. In vitro activity of dietary flavonol congeners against human cancer cell lines. European Journal of Nutrition. 2011 May 20;51(2):181–90. doi: 10.1007/s00394-011-0204-5. 参考文献:10.1055/s-2008-1074547 摘要:Ren ZY, Qi HY, Shi YP. Phytochemical investigation of Anaphalis lactea. Planta Med. 2008 Jun;74(8):859–63. doi: 10.1055/s-2008-1074547.