CAS: 182210-71-5; ((3R,5R)-5-(2,4-Difluorophenyl)-5-(Iodomethyl)Tetrahydrofuran-3-yl) Methanol
化学文摘社编号182210-71-5为名称的化学物质具有复杂的分子结构特征,其中包括一个四氢呋喃环,一个二氟苯基组和一个碘甲基替代体.这种化合物具有四氢呋喃3和5个位置的立体点,有助于其体力并有可能影响其生物活动和相互作用.二氟苯基混合物的存在表明,它可能具有独特的电子特性,而二氟基甲基混合物组则能够增强再活动性,使其成为各种化学变异的候选物.此外,氢甲基组表明,该化合物可能参与氢联结,影响其溶解剂的溶解性和再活性.
相似化合物
165115-82-2 1042398-26-4 2170933-06-7MSDS等安全信息
上下游产品
(R)-4-benzyl-3-((3S,5R)-5-(2,4-difluorophenyl)-5-(iodomethyl)tetrahydrofuran-3-carbonyl)oxazolidin-2-one 4-(2,4-difluorophenyl)-pent-4-enoic acid 4-(2,4-difluorophenyl)-4-oxobutanoic acid ((3R,5R)-5-((1H-1,2,4-triazole-1-yl) methyl)-5-(2,4-difluorophenyl) tetrahydrofuran-3-yl)methanol 4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2S,3S)-2-(benzyloxy)pentan-3-yl)-1H-1,2,4-triazol-5(4H)-one posaconazote ((3S,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-chlorobenzenesulfonate合成工艺路线路线简述
海关参考信息
- 2902600000-乙苯
2902700000-异丙基苯
2905122000-异丙醇
2905399001-1,3-丙二醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
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专利信息
专利号:WO-2019077627-A1
优先权日:2017-10-16
标题:PROCESS FOR PRODUCING POSACONAZOLE
发明人：NANDEPU Venkateswara Rao; BIJJULA VENKATA KRISHNA REDDY; BATHINA Satyanarayana
权利人:METROCHEM API PVT LTD
摘要:The present invention relates to an improved process for the manufacture of Posaconazole, an antifungal agent belonging to the category of triazole compound substituted tetrahydrofuran. The present invention further relates to the preparation of Formula A and Formula B, key intermediates in the preparation of Posaconazole. The invention also relates to novel intermediates that are useful in the synthesis of Posaconazole.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2008).
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