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📜硫光气,邻氨基苯甲酸甲酯置于碳酸氢钠体系中,化学反应生成2-异硫氰基苯甲酸甲酯
参考文献:带有磺胺吡啶部分的新型喹唑啉衍生物作为抗癌剂和放射增敏剂
标题:带有磺胺吡啶部分的新型喹唑啉衍生物作为抗癌剂和放射增敏剂
摘要:喹唑啉衍生物具有许多类型的生物学活性,最近已报道其在体外和/或体内显示出显着的抗肿瘤活性.它们的抗癌活性有多种机制.本工作报告了可能的效用邻氨基苯甲酸甲酯在一些新的喹唑啉衍生物的合成中,带有取代的磺酰胺部分.使用阿霉素作为参考药物,评估所有新合成的化合物对人肝癌细胞的体外抗癌活性.此外,活性最高的化合物 和 选择并评估它们增强γ射线对细胞的杀伤作用的能力.
Doi:10.1002/jhet.1830

专利信息

专利号:US-6872727-B1
优先权日:1999-08-26
标 题:Polycyclic pyrimidine -2,4(1H,3H)-diones with functionalized alkyl residues at the 1- and/or 3-position(s); methods for their synthesis and pharmaceutical preparation
发明人：HERRMANN KONRAD; LEISTNER SIEGFRIED; WIPPICH PETRA
权利人:PRIVATES INST FUR BIOMEDIZINIS
摘要:Polycyclic pyrimidine-2,4(1H,3H)-diones with functionalized alkyl residues at the 1-, the 3-, or both position(s); methods for their synthesis, production, and pharmaceutical preparation. The invention concerns the synthesis of the above-described compounds, their chemical and structural characterization, and the analysis of their physiological/pharmacological activities in vitro and in vivo. These goals have been attained by the specification of routes of synthesis, methods for the production of the compounds, and the presentation of compound-specific characteristics. The substances encompassed by the present invention demonstrate pharmacologically significant collangenase/matrix metalloproteinase inhibitory activities. The specific example 1-(3-mercaptoprop-1-yl)-3-methyl-chinazolin-2,4(1H,3H)-dione will be presented in detail.